1. Heparin-binding EGF-like growth factor (HB-EGF) therapy for intestinal injury: Application and future prospects.
- Author
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Yang, Jixin, Su, Yanwei, Zhou, Yu, and Besner, Gail E.
- Subjects
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EPIDERMAL growth factor , *HEPARIN , *INTESTINAL injuries , *INTESTINAL ischemia , *HEMORRHAGIC shock , *ANIMAL models in research , *THERAPEUTICS - Abstract
Abstract: Throughout the past 20 years, we have been investigating the potential therapeutic roles of heparin-binding EGF-like growth factor (HB-EGF), a member of the epidermal growth factor family, in various models of intestinal injury including necrotizing enterocolitis (NEC), intestinal ischemia/reperfusion (I/R) injury, and hemorrhagic shock and resuscitation (HS/R). Our studies have demonstrated that HB-EGF acts as an effective mitogen, a restitution-inducing reagent, a cellular trophic factor, an anti-apoptotic protein and a vasodilator, via its effects on various cell types in the intestine. In the current paper, we have reviewed the application and therapeutic effects of HB-EGF in three classic animal models of intestinal injury, with particular emphasis on its protection of the intestines from NEC. Additionally, we have summarized the protective functions of HB-EGF on various target cells in the intestine. Lastly, we have provided a brief discussion focusing on the future development of HB-EGF clinical applications for the treatment of various forms of intestinal injury including NEC. [Copyright &y& Elsevier]
- Published
- 2014
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