Search

Your search keyword '"necrotizing enterocolitis"' showing total 2 results
Start Over Descriptor "necrotizing enterocolitis" Topic acidosis Journal pathophysiology
2 results on '"necrotizing enterocolitis"'

1. Feeding associated neonatal necrotizing enterocolitis (Primary NEC) is an inflammatory bowel disease.

Author

Clark, David A. and Munshi, Upender K.

Subjects
*NEONATAL necrotizing enterocolitis, *INFLAMMATORY bowel diseases, *PREMATURE infants, *ACIDOSIS, *GUT microbiome, *ORGANIC acids, *THERAPEUTICS
Abstract

Abstract: Neonatal necrotizing enterocolitis which develops after feeding preterm infants is characterized by severe intestinal inflammation and profound systemic metabolic acidosis. The fermentation of undigested dietary carbohydrate by colonic flora yields gases (CO2 and H2) and short chain organic acids. These organic acids can disrupt the intestinal mucosa and initiate inflammation driven predominantly by resident mast cells and by granulocytes which are recruited from blood. A systemic acidosis ensues derived from intestinal acids, not classic lactic acidosis produced from anaerobic metabolism. The systemic acidosis further compromises inflamed bowel leading to bowel necrosis. [Copyright &y& Elsevier]

Published
2014
Full Text
View/download PDF

2. Feeding associated neonatal necrotizing enterocolitis (Primary NEC) is an inflammatory bowel disease

Author

David A. Clark and Upender K. Munshi

Subjects
medicine.medical_specialty, business.industry, Metabolic acidosis, Inflammation, medicine.disease, Gastroenterology, Inflammatory bowel disease, Article, Pathology and Forensic Medicine, Intestinal mucosa, Necrotizing enterocolitis, Organic acids, Physiology (medical), Lactic acidosis, Internal medicine, Immunology, Mast cells, medicine, medicine.symptom, business, Anaerobic exercise, Acidosis
Abstract

Neonatal necrotizing enterocolitis which develops after feeding preterm infants is characterized by severe intestinal inflammation and profound systemic metabolic acidosis. The fermentation of undigested dietary carbohydrate by colonic flora yields gases (CO2 and H2) and short chain organic acids. These organic acids can disrupt the intestinal mucosa and initiate inflammation driven predominantly by resident mast cells and by granulocytes which are recruited from blood. A systemic acidosis ensues derived from intestinal acids, not classic lactic acidosis produced from anaerobic metabolism. The systemic acidosis further compromises inflamed bowel leading to bowel necrosis.

Published
2014

Catalog

Books, media, physical & digital resources
See catalog results