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Your search keyword '"Toguchida, Junya"' showing total 6 results
Start Over Author "Toguchida, Junya" Journal pathology international
6 results on '"Toguchida, Junya"'

2. Primary central chondrosarcoma of long bone, limb girdle and trunk: Analysis of 174 cases by numerical scoring on histology

Author

Konishi, Eiichi, Nakashima, Yasuaki, Mano, Masayuki, Tomita, Yasuhiko, Nagasaki, Ikumitsu, Kubo, Toshikazu, Araki, Nobuhito, Haga, Hironori, Toguchida, Junya, Ueda, Takafumi, Sakuma, Toshiko, Imahori, Masaya, Morii, Eiichi, Yoshikawa, Hideki, Tsukamoto, Yoshitane, Futani, Hiroyuki, Wakasa, Kenichi, Hoshi, Manabu, Hamada, Shinshichi, Takeshita, Hideyuki, Inoue, Takeshi, Aono, Masanari, Kawabata, Kenji, Murata, Hiroaki, Katsura, Kanade, Urata, Yoji, Ueda, Hideki, and Yanagisawa, Akio

Published
2015
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4. Giant cell tumor of bone – Analysis of 213 cases involving extra‐craniofacial bones

Author

Konishi, Eiichi, primary, Outani, Hidetatsu, additional, Mano, Masayuki, additional, Nagata, Shigenori, additional, Shirai, Toshiharu, additional, Naka, Norifumi, additional, Hori, Yumiko, additional, Takenaka, Satoshi, additional, Haga, Hironori, additional, Toguchida, Junya, additional, Kakunaga, Shigeki, additional, Kuwae, Yuko, additional, Hoshi, Manabu, additional, Inoue, Takeshi, additional, Aono, Masanari, additional, Morinaga, Yukiko, additional, and Nakashima, Yasuaki, additional

Published
2021
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6. TLS-CHOP target geneDOL54 expression in liposarcomas and malignant fibrous histiocytomas.

Author

Domoto, Hideharu, Hosaka, Taisuke, Oikawa, Kosuke, Ohbayashi, Tetsuya, Ishida, Tsuyoshi, Izumi, Miki, Iwaya, Keiichi, Toguchida, Junya, Kuroda, Masahiko, and Mukai, Kiyoshi

Subjects
LIPOSARCOMA, DERMATOFIBROMA, ONCOGENES, GENETICS
Abstract

Downstream of the gene for the liposarcoma-associated fusion oncoprotein 54 (DOL54) is a target gene of the myxoid liposarcoma and round cell liposarcoma (M-LPS/ RC-LPS) oncogene, TLS/FUS-CHOP. The DOL54 gene product is closely associated with adipogenic differentiation. DOL54 overexpression resulted in tumorigenicity when Chinese Hamster Ovary (CHO) cells were injected subcutaneously into nude mice. The biological significance of DOL54 expression for human malignant soft tissue tumors, however, has not yet been investigated. We examined TLS-CHOP and DOL54 expression in M-LPS/RC-LPS, welldifferentiated liposarcoma and malignant fibrous histiocytoma (MFH), a tumor whose cellular origin has not been determined. We observed DOL54 expression in 50% of M-LPS/RC-LPS cases (in which TLS-CHOP was also expressed) and 33% of MFH cases, suggesting that a portion of MFH lesions may either derive from adipocytic precursor cells or have the potential to undergo adipogenic differentiation. In this manner, M-LPS/RC-LPS and MFH lesions may share tumorigenic characteristics, resulting from the unscheduled expression of DOL54. [ABSTRACT FROM AUTHOR]

Published
2002
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