1. Myoepithelioma-like tumor of the vulvar region showing infiltrative growth and harboring only a few estrogen receptor-positive cells: A case report
- Author
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Mikiko Tanabe, Masako Otani, Yui Kojima, Toru Motoi, Ikuma Kato, Tomoe Sawazumi, Yoshiaki Inayama, Sawako Chiba, Reiko Tanaka, and Mariko Kimura
- Subjects
0301 basic medicine ,Pathology ,medicine.medical_specialty ,Myoepithelioma ,Estrogen receptor ,S100 protein ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Biomarkers, Tumor ,Humans ,SMARCB1 ,Gene Rearrangement ,Glial fibrillary acidic protein ,biology ,medicine.diagnostic_test ,Mucin-1 ,General Medicine ,Gene rearrangement ,Immunohistochemistry ,030104 developmental biology ,Receptors, Estrogen ,030220 oncology & carcinogenesis ,biology.protein ,Calmodulin-Binding Proteins ,Fluorescence in situ hybridization - Abstract
Recently, a new entity "myoepithelioma-like tumor of the vulvar region (MELTVR)" was proposed as a rare mesenchymal neoplasm arising in vulvar regions of adult women. While MELTVRs morphologically resemble soft tissue myoepitheliomas and extraskeletal myxoid chondrosarcomas, they have a unique immunohistochemical profile (positive for epithelial membrane antigen and estrogen receptor, negative for S100 protein and glial fibrillary acidic protein, and loss of INI1/SMARCB1 expression), and lack EWSR1 and NR4A3 gene rearrangement, as seen by fluorescence in situ hybridization. MELTVRs are usually well-demarcated tumors, with no reports of extensive infiltrative growth. In the current report, we present an unusual case of MELTVR showing infiltrative growth and harboring only a few estrogen receptor-positive cells, which might indicate a variation in this rare tumor.
- Published
- 2018