1. PDZK1IP1 gene promotes proliferation, migration, and invasion in papillary thyroid carcinoma.
- Author
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Zhang, Wei, Zheng, Danni, Jin, Lingli, Hirachan, Suzita, Bhandari, Adheesh, Li, Yulian, Chen, Buran, Lu, Yiqiao, Wen, Jialiang, Lin, Bangyi, Zhang, Xiaohua, and Chen, Chengze
- Subjects
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PAPILLARY carcinoma , *THYROID cancer , *INHIBITION of cellular proliferation , *CELL cycle - Abstract
Thyroid cancer is a common malignant tumor for the adult and the potential molecular mechanism of papillary thyroid cancer cell metastasis is still unclear. We used sequencing techniques to analyze paired papillary thyroid carcinoma (PTC) and adjacent thyroid tissue and identified a gene, PDZK1IP1, that was significantly overexpressed in thyroid cancer. We found It has been detected to play an important role in many malignant tumors. But the role in papillary thyroid cancer was still unknown, we decided to find a new marker and therapeutic target for the disease. The present study shows that PDZK1IP1 may be a potential gene that leads to thyroid cancer. In our study, silencing PDZK1IP1 can inhibit PTC cell proliferation, migration, invasion, apoptosis, and cell cycle arrest. This study surmised that PDZK1IP1 was an oncogene that correlated with tumor development. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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