1. Can immune markers help identify fast relapse in patients with muscle invasive bladder cancer?
- Author
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Olkhov-Mitsel, Ekaterina, Hodgson, Anjelica, Liu, Stanley K., Vesprini, Danny, Bayani, Jane, Bartlett, John M.S., Xu, Bin, and Downes, Michelle R.
- Subjects
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BIOMARKERS , *DISEASE relapse , *UROTHELIUM , *BLADDER cancer , *TRANSITIONAL cell carcinoma , *LOG-rank test - Abstract
The aim of this pilot study was to assess the role of immune markers in fast relapse (<2 years) of high-grade muscle invasive urothelial carcinomas of the bladder (HGUC) treated by cystectomy. A series of 40 such cases was investigated for immune protein (CD3, CD4, CD8, CD20, CD68, CD163, FOXP3 and PD-1) status by immunohistochemistry. Decreased expression of all immune cell markers was observed in tumors of patients who relapsed quickly. In Kaplan-Meier (log-rank test) analysis, low CD3, CD4 and CD8 expression was associated with fast relapse (P = 0.005, 0.028, 0.036 respectively). Additional evaluation of the immune transcriptome by NanoString Human PanCancer Immune Panel v.1.1 has identified 5 differentially expressed genes significantly associated with fast relapse. Among these, KLRB1 and HLA-DQA1 were also significant on Kaplan-Meier analysis (log-rank test P = 0.007 and 0.006, respectively). These findings strengthen the potential clinical utility and, hence, the need for further evaluation of immune markers in HGUC prognostication. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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