36 results on '"Wood BA"'
Search Results
2. Metastatic atypical fibroxanthoma: the importance of structured reporting for cutaneous sarcoma-like tumour.
- Author
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Yap M, Harvey NT, Mesbah Ardakani N, and Wood BA
- Subjects
- Humans, Histiocytoma, Benign Fibrous pathology, Histiocytoma, Benign Fibrous diagnosis, Male, Female, Aged, Diagnosis, Differential, Skin Neoplasms pathology, Skin Neoplasms diagnosis, Sarcoma pathology, Sarcoma diagnosis
- Published
- 2024
- Full Text
- View/download PDF
3. Bowen disease is not synonymous with intraepidermal squamous cell carcinoma.
- Author
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Wood BA, Harvey NT, Mesbah Ardakani N, and Paton D
- Subjects
- Humans, Bowen's Disease pathology, Skin Neoplasms pathology, Carcinoma, Squamous Cell pathology, Keratosis, Actinic pathology, Anus Neoplasms
- Abstract
The terms 'Bowen disease' and 'intraepidermal squamous cell carcinoma' are sometimes considered synonymous. In this paper we present historical, clinical, histological and molecular evidence that this is incorrect. The term Bowen disease should be reserved for a subset of intraepidermal squamous cell carcinoma with a distinctive and reproducible morphological pattern, described in detail by Bowen in 1912. One other common subset of intraepidermal squamous cell carcinoma represents progression of actinic keratosis. In some cases the separation of these two common patterns of intraepidermal squamous cell carcinoma can be challenging and there are patterns of intraepidermal squamous cell carcinoma which appear to represent other distinct pathways. However, there is emerging biological evidence to support this distinction and reason to suspect that the types of invasive squamous cell carcinoma which arise from these different pathways may show important clinical and biological differences, particularly in the era of targeted and immunomodulatory therapy for advanced disease., (Copyright © 2024 Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
4. Expression of Melan-A in cutaneous granular cell tumours: a diagnostic pitfall.
- Author
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Van Winden VI, Wong DD, Wood BA, Filion P, and Harvey NT
- Subjects
- Humans, MART-1 Antigen, Antigens, Neoplasm metabolism, Biomarkers, Tumor metabolism, Antibodies, Monoclonal, Transcription Factors, Diagnosis, Differential, Melanoma pathology, Granular Cell Tumor diagnosis, Skin Neoplasms pathology
- Abstract
Morphological overlap exists between cutaneous granular cell tumours (GCT) and malignant melanoma, with the melanocyte-specific markers HMB45 and Melan-A commonly used to support the diagnosis of melanoma. We recently encountered several cases of GCT in our practice showing strong expression of Melan-A. The aim of this study was to establish the prevalence of positive immunohistochemical staining for Melan-A and HMB45 in a series of unequivocal GCTs. We also aimed to assess the prevalence of staining for PRAME (PReferentially expressed Antigen in MElanoma), a marker expressed in >80% of primary melanomas as well as many non-melanocytic tumours. A total of 20 cutaneous/subcutaneous GCTs were evaluated using Melan-A, HMB45 and PRAME immunohistochemistry. Staining for Melan-A and HMB45 was scored using a semiquantitative scale from 0 (absent) to 3+ (staining present in >50% of tumour cells). PRAME expression was recorded as either positive (>75% of cell nuclei staining) or negative. Melan-A expression was observed in four GCTs (20%), with strong and diffuse (3+) staining seen in two cases (10%), both from anogenital areas. Weak patchy nuclear PRAME expression was seen in every case, interpreted to be negative. HMB45 was also negative in all cases (100%). Our study demonstrates that Melan-A expression can be strong and diffuse in a subset of otherwise unequivocal cutaneous GCTs, which may cause diagnostic confusion with malignant melanoma. HMB45 and PRAME did not stain any of the GCTs in our series., (Copyright © 2023 Royal College of Pathologists of Australasia. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
5. BRAF mutated and morphologically Spitzoid naevus/atypical Spitz tumour.
- Author
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Wood BA, Mesbah Ardakani N, Ryan B, and Amanuel B
- Subjects
- Humans, Proto-Oncogene Proteins B-raf genetics, Diagnosis, Differential, Nevus, Epithelioid and Spindle Cell diagnosis, Nevus, Epithelioid and Spindle Cell genetics, Skin Neoplasms diagnosis, Skin Neoplasms genetics, Skin Neoplasms pathology, Nevus, Pigmented
- Published
- 2023
- Full Text
- View/download PDF
6. BRAF mutation testing for patients diagnosed with stage III or stage IV melanoma: practical guidance for the Australian setting.
- Author
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Scolyer RA, Atkinson V, Gyorki DE, Lambie D, O'Toole S, Saw RPM, Amanuel B, Angel CM, Button-Sloan AE, Carlino MS, Ch'ng S, Colebatch AJ, Daneshvar D, Pires da Silva I, Dawson T, Ferguson PM, Foster-Smith E, Fox SB, Gill AJ, Gupta R, Henderson MA, Hong AM, Howle JR, Jackett LA, James C, Lee CS, Lochhead A, Loh D, McArthur GA, McLean CA, Menzies AM, Nieweg OE, O'Brien BH, Pennington TE, Potter AJ, Prakash S, Rawson RV, Read RL, Rtshiladze MA, Shannon KF, Smithers BM, Spillane AJ, Stretch JR, Thompson JF, Tucker P, Varey AHR, Vilain RE, Wood BA, and Long GV
- Subjects
- Australia, Biomarkers, Tumor genetics, Biomarkers, Tumor metabolism, DNA Mutational Analysis, Guidelines as Topic, Humans, Immunohistochemistry methods, Molecular Targeted Therapy, Mutation, National Health Programs, Neoplasm Staging, Proto-Oncogene Proteins B-raf metabolism, Skin Neoplasms diagnosis, Skin Neoplasms pathology, Skin Neoplasms therapy, Melanoma diagnosis, Melanoma pathology, Melanoma therapy, Proto-Oncogene Proteins B-raf genetics
- Abstract
Targeted therapy (BRAF inhibitor plus MEK inhibitor) is now among the possible treatment options for patients with BRAF mutation-positive stage III or stage IV melanoma. This makes prompt BRAF mutation testing an important step in the management of patients diagnosed with stage III or IV melanoma; one that can help better ensure that the optimal choice of systemic treatment is initiated with minimal delay. This article offers guidance about when and how BRAF mutation testing should be conducted when patients are diagnosed with melanoma in Australia. Notably, it recommends that pathologists reflexively order BRAF mutation testing whenever a patient is found to have American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) stage III or IV melanoma (i.e., any metastatic spread beyond the primary tumour) and that patient's BRAF mutation status is hitherto unknown, even if BRAF mutation testing has not been specifically requested by the treating clinician (in Australia, Medicare-subsidised BRAF
V600 mutation testing does not need to be requested by the treating clinician). When performed in centres with appropriate expertise and experience, immunohistochemistry (IHC) using the anti-BRAF V600E monoclonal antibody (VE1) can be a highly sensitive and specific means of detecting BRAFV600E mutations, and may be used as a rapid and relatively inexpensive initial screening test. However, VE1 immunostaining can be technically challenging and difficult to interpret, particularly in heavily pigmented tumours; melanomas with weak, moderate or focal BRAFV600E immunostaining should be regarded as equivocal. It must also be remembered that other activating BRAFV600 mutations (including BRAFV600K ), which account for ∼10-20% of BRAFV600 mutations, are not detected with currently available IHC antibodies. For these reasons, if available and practicable, we recommend that DNA-based BRAF mutation testing always be performed, regardless of whether IHC-based testing is also conducted. Advice about tissue/specimen selection for BRAF mutation testing of patients diagnosed with stage III or IV melanoma is also offered in this article; and potential pitfalls when interpreting BRAF mutation tests are highlighted., (Copyright © 2021 Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights reserved.)- Published
- 2022
- Full Text
- View/download PDF
7. Large nested melanoma: a clinicopathological, morphometric and cytogenetic study of 12 cases.
- Author
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Leecy TN, McQuillan P, Harvey NT, Mesbah Ardakani N, Van Vliet C, Peverall J, Kennedy D, Sivamoorthy S, Fruvall A, Rijhumal H, Uzaraga J, Singh S, and Wood BA
- Subjects
- Adult, Aged, Aged, 80 and over, Cytogenetic Analysis, Female, Humans, Male, Middle Aged, Retrospective Studies, Chromosome Aberrations, Melanoma genetics, Melanoma pathology, Skin Neoplasms genetics, Skin Neoplasms pathology
- Abstract
A group of melanomas characterised by predominant growth as large nests within the epidermis has been described. These cases present a diagnostic challenge, as many traditional architectural criteria for the recognition of melanoma are absent. We report the clinical, histological, immunohistochemical, morphometric and cytogenetic features of a series of 12 cases of large nested melanoma. In this series, large nested melanoma accounted for 0.2% of cases of melanoma. The majority occurred on the trunk of middle aged patients with absent or minimal solar elastosis and 42% were associated with a component of benign intradermal melanocytic naevus, speaking to classification of these melanomas as falling within the spectrum of lesions developing in skin with low cumulative sun damage. In 67% of cases invasive melanoma was present. Criteria such as asymmetry, variation in nest size and intraepidermal nests with an underlying rim of junctional keratinocytes appear to be highly specific, and are strongly predictive of typical cytogenetic abnormalities of melanoma, which were identified in 92% of cases. Conversely, in addition to features which are definitionally absent or limited, features such as solar elastosis and cytological atypia do not appear to be particularly helpful in recognition of this variant., (Copyright © 2020 Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
8. Cutaneous tumoural melanosis: a presentation of complete regression of cutaneous melanoma.
- Author
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Ching D, Amini E, Harvey NT, Wood BA, and Mesbah Ardakani N
- Subjects
- Aged, Brain pathology, Female, GTP Phosphohydrolases metabolism, Humans, Lymph Nodes pathology, Male, Membrane Proteins metabolism, Middle Aged, Mutation, Neoplasm Metastasis, Proto-Oncogene Proteins B-raf metabolism, Melanoma, Cutaneous Malignant, GTP Phosphohydrolases genetics, Melanoma pathology, Melanosis pathology, Membrane Proteins genetics, Proto-Oncogene Proteins B-raf genetics, Skin Neoplasms pathology
- Abstract
Partial regression is common in cutaneous melanoma; however, complete regression manifesting as tumoural melanosis is rare, conceptually challenging and under-reported. In this study we report on clinical, histological and molecular findings in four cases of completely regressed cutaneous melanoma with nodal or brain metastasis, followed by a comprehensive review of the literature. Our series included three women and one man with an average age of 60 years, and clinical presentation with hyper-pigmented cutaneous lesions. The main histological findings were expansile aggregates of melanophages with complete absence of malignant melanocytes on microscopic and immunohistochemical examination of the entire primary skin lesions, as well as substantial reduction in the number of junctional melanocytes in the overlying epidermis. NRAS mutant/BRAF wild type metastatic deposits were identified in three patients, with one patient having a BRAF V600E mutant metastatic tumour. Tumoural melanosis likely represents a partially effective immunological response to melanoma, with complete eradication of cutaneous disease and less effective systemic results. Patients with tumoural melanosis should be managed as potential completely regressed cutaneous melanoma, with comprehensive physical examination, imaging work up and close follow up., (Crown Copyright © 2019. Published by Elsevier B.V. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
9. Pilomatrical carcinosarcoma: report of a case with comparative genomic hybridisation analysis.
- Author
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Leecy T, Ardakani NM, Harvey NT, and Wood BA
- Subjects
- Aged, 80 and over, Carcinosarcoma pathology, Chromosome Aberrations, Comparative Genomic Hybridization, Cyclin-Dependent Kinase Inhibitor p16, Cyclin-Dependent Kinase Inhibitor p18 genetics, Female, Humans, Skin Neoplasms pathology, Carcinosarcoma genetics, Skin Neoplasms genetics
- Published
- 2018
- Full Text
- View/download PDF
10. Subungual acantholytic dyskeratotic acanthoma: an unusual cause of longitudinal erythronychia.
- Author
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Ng J, Harvey NT, von Nida J, and Wood BA
- Subjects
- Adult, Humans, Male, Acanthoma pathology, Nail Diseases pathology, Skin Neoplasms pathology
- Published
- 2018
- Full Text
- View/download PDF
11. Localised lymphoedema forming a papillated lesion on the scalp.
- Author
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Korbl JD, Chan J, Wood BA, and Harvey NT
- Subjects
- Adult, Humans, Lymphedema pathology, Male, Lymphedema diagnosis, Scalp pathology
- Published
- 2018
- Full Text
- View/download PDF
12. 'Why don't they ever call?' Expectations of clinicians and pathologists regarding the communication of critical diagnoses in dermatopathology.
- Author
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Korbl JD, Wood BA, and Harvey NT
- Subjects
- Humans, Surveys and Questionnaires, Attitude of Health Personnel, Dermatology, Interprofessional Relations, Pathology, Surgical, Referral and Consultation
- Abstract
Certain diagnoses in dermatopathology have significant implications for patient management and on occasion appropriate clinical care may be facilitated by a phone call from the reporting dermatopathologist to the referring doctor. Whether this is appropriate depends on a number of factors. The concept of 'critical diagnoses' is now well established in surgical pathology, having evolved from critical value policies in clinical pathology and haematology. However, only limited attempts have been made to assess perceptions among different clinical groups. We designed a survey to assess the attitudes of pathologists, dermatologists, surgeons and general practitioners as to what circumstances warrant telephone contact in addition to a standard written report, as well as their approaches to routine histology follow-up. The survey was distributed Australia-wide via a combination of specialist colleges, medical forums and collegiate contacts. A total of 262 responses were received, encompassing representations from all of the targeted specialties. Approximately 20% of respondents were aware of adverse outcomes or 'near misses' which they felt had been due in some part to inadequate communication of histopathology results. While most practitioners have formal systems in place to review histopathology reports, this practice is not universal. There were a number clinical situations where there was a discrepancy between the expectations of clinicians and those of pathologists, in particular with regard to a diagnosis of cutaneous melanoma as well as cutaneous lesions which might be associated with inherited cancer syndromes. It is our hope that the results of this study will facilitate discussion between pathologists and referring clinicians at a local level to minimise the potential for miscommunication., (Crown Copyright © 2018. Published by Elsevier B.V. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
13. Sebaceous lesions of the skin.
- Author
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Iacobelli J, Harvey NT, and Wood BA
- Subjects
- Humans, Immunohistochemistry, Skin pathology, Adenocarcinoma, Sebaceous pathology, Hyperplasia pathology, Muir-Torre Syndrome pathology, Sebaceous Gland Neoplasms pathology
- Abstract
Sebaceous differentiation is commonly seen in cutaneous neoplasms, both in the context of lesions showing predominantly sebaceous differentiation (e.g., sebaceous adenoma, sebaceoma and sebaceous carcinoma), or as more focal sebaceous components in neoplasms with other primary lines of differentiation. Sebaceous changes can also be a component of benign cystic lesions or epidermal tumours, and sebaceous hyperplasia is commonly encountered. This review is intended to provide an overview of the cutaneous lesions with sebaceous differentiation, with a particular emphasis on facilitating histological diagnosis of neoplasms. In addition, the role of immunohistochemical studies is outlined, as well as the evaluation of potential cases of Muir-Torre syndrome., (Copyright © 2017 Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights reserved.)
- Published
- 2017
- Full Text
- View/download PDF
14. Detection of copy number variations in melanocytic lesions utilising array based comparative genomic hybridisation.
- Author
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Mesbah Ardakani N, Thomas C, Robinson C, Mina K, Harvey NT, Amanuel B, and Wood BA
- Subjects
- Adult, Aged, Aged, 80 and over, Chromosome Aberrations, Comparative Genomic Hybridization methods, Female, Humans, In Situ Hybridization, Fluorescence methods, Male, Melanoma diagnosis, Middle Aged, Skin Neoplasms diagnosis, Young Adult, DNA genetics, DNA Copy Number Variations genetics, Melanoma genetics, Skin Neoplasms genetics
- Abstract
Distinction between melanocytic naevi and melanoma occasionally poses a diagnostic challenge in ambiguous cases showing overlapping histological features. Melanomas are characterised by the presence of multiple genomic copy number variants (CNVs), while this is not a feature of naevi. We assessed the feasibility and utility of array-based comparative genomic hybridisation (aCGH) to assess CNVs in melanocytic lesions. DNA was extracted from formalin fixed, paraffin embedded (FFPE) sections of unambiguous naevi (n=19) and melanomas (n=19). The test DNA and gender mismatched human reference DNA were differentially labelled with fluorophores. Equal quantities of the two DNA samples were mixed and co-hybridised to a SurePrint G3 Human CGH 8x60K array, and digitally scanned to capture and quantify the relative fluorescence intensities. The ratio of the fluorescence intensities was analysed by Cytogenomics software (Agilent). Frequent large CNVs were identified in 94.7% of melanoma samples, including losses of 9p (73.6%), 9q (52.6%), 10q (36.8%), 11q (36.8%), 3p (21%), and 10p (21%), and gains of 6p (42.1%), 7p (42.1%), 1q (36.8%), 8q (31.5%) and 20q (21%). Only one naevus showed two large copy number changes. Overall aCGH showed a specificity and sensitivity of 94.7% in separating naevi from melanomas. Based on our results, aCGH can be successfully used to analyse CNVs of melanocytic lesions utilising FFPE derived biopsy samples, providing a potentially useful adjunctive test for the classification of diagnostically challenging melanocytic proliferations., (Crown Copyright © 2017. Published by Elsevier B.V. All rights reserved.)
- Published
- 2017
- Full Text
- View/download PDF
15. Paediatric cutaneous adnexal tumours: a study of 559 cases.
- Author
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Ireland AM, Harvey NT, Berry BD, and Wood BA
- Subjects
- Adolescent, Biomarkers, Tumor analysis, Child, Child, Preschool, Female, Head and Neck Neoplasms diagnosis, Head and Neck Neoplasms pathology, Humans, Infant, Male, Skin Neoplasms diagnosis, Sweat Gland Neoplasms diagnosis, Neoplasms, Adnexal and Skin Appendage diagnosis, Neoplasms, Adnexal and Skin Appendage pathology, Sebaceous Glands pathology, Skin Neoplasms pathology, Sweat Gland Neoplasms pathology
- Abstract
Cutaneous adnexal tumours encompass a wide group of lesions with apocrine, eccrine, follicular, sebaceous and mixed differentiation. The large majority are benign and represent sporadic lesions, though malignant forms are occasionally encountered and some cases develop in the setting of inherited tumour syndromes. Accurate histological classification can be difficult as there are numerous histological appearances, many of which are individually uncommon, and complex, overlapping and historically variable nomenclature is typical. The aim of this study was to review and classify the spectrum of cutaneous adnexal tumours seen in patients 18 years of age and under in two major tertiary centres over a 20 year period. A total of 559 cases were included, with 60% occurring in female patients. The large majority (87%) occurred in the head and neck region and were benign. Only one (0.2%) was malignant. The original diagnosis was supported by histological review in 99% of cases of pilomatricoma reviewed, but in only 71% of non-pilomatricoma cases reviewed. The most common lineage was follicular (97%), with pilomatricoma accounting for the large majority of lesions. Predominant glandular/ductal differentiation was seen in 3% of cases, with no tumours showing predominant sebaceous differentiation., (Copyright © 2016 Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights reserved.)
- Published
- 2017
- Full Text
- View/download PDF
16. Epidermotropic CD8 positive lymphoproliferative diseases: histological and immunophenotypic similarities but markedly differing clinical behaviour.
- Author
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Paton DJ, Van Vliet C, Prasad Kumarasinghe S, Chan JJ, and Wood BA
- Subjects
- Adolescent, Adult, Biomarkers analysis, Female, Humans, Immunophenotyping, Lymphoma, T-Cell, Cutaneous immunology, Lymphomatoid Papulosis immunology, Lymphoproliferative Disorders immunology, Lymphoproliferative Disorders pathology, Male, Middle Aged, Mycosis Fungoides immunology, Skin Neoplasms immunology, Lymphoma, T-Cell, Cutaneous pathology, Lymphomatoid Papulosis pathology, Mycosis Fungoides pathology, Skin Neoplasms pathology
- Published
- 2016
- Full Text
- View/download PDF
17. Extramammary Paget's disease of the scalp presenting with a concurrent basal cell carcinoma.
- Author
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Kang A, Wood BA, Gurfinkel R, and Harvey NT
- Subjects
- Aged, Biomarkers, Tumor analysis, Female, Humans, Immunohistochemistry, Carcinoma, Basal Cell pathology, Head and Neck Neoplasms pathology, Neoplasms, Multiple Primary pathology, Paget Disease, Extramammary pathology, Scalp pathology, Skin Neoplasms pathology
- Published
- 2016
- Full Text
- View/download PDF
18. Circumscribed sebaceous neoplasms: a morphological, immunohistochemical and molecular analysis.
- Author
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Harvey NT, Tabone T, Erber W, and Wood BA
- Subjects
- Aged, Aged, 80 and over, Cyclin-Dependent Kinase Inhibitor p16 analysis, Cyclin-Dependent Kinase Inhibitor p16 biosynthesis, DNA Mutational Analysis, ErbB Receptors genetics, Female, High-Throughput Nucleotide Sequencing, Humans, Immunohistochemistry, Male, Middle Aged, Proto-Oncogene Proteins c-bcl-2 analysis, Proto-Oncogene Proteins c-bcl-2 biosynthesis, Proto-Oncogene Proteins p21(ras) genetics, Tumor Suppressor Protein p53 analysis, Tumor Suppressor Protein p53 biosynthesis, Tumor Suppressor Protein p53 genetics, beta Catenin genetics, Biomarkers, Tumor analysis, Sebaceous Gland Neoplasms diagnosis, Sebaceous Gland Neoplasms genetics, Sebaceous Gland Neoplasms pathology
- Abstract
Sebaceous neoplasms encompass a range of lesions, including benign entities such as sebaceous adenoma and sebaceoma, as well as sebaceous carcinoma. The distinction of sebaceous carcinoma from benign lesions relies on histological identification of architectural or cytological features of malignancy. In this study we have assessed the diagnostic discriminatory ability of mitotic rate and immunohistochemical markers (p53, bcl-2 and p16) in a selected group of well circumscribed sebaceous neoplasms, incorporating examples of sebaceous adenoma, sebaceoma and sebaceous carcinoma. We found that mitotic rate was significantly higher in malignant lesions as compared to benign lesions, but none of the immunohistochemical markers showed a discriminatory expression pattern. In addition, we performed a mutational analysis on the same group of lesions using next generation sequencing (NGS) technology. The most commonly mutated gene was TP53, although there was no correlation between the p53 immunohistochemical results and number or type of TP53 mutation detected. CDKN2A, EGFR, CTNNB1 and KRAS were also commonly mutated across all lesions. No particular gene, mutation profile or individual mutation could be identified which directly correlated with the consensus histological diagnosis. In conclusion, within this diagnostically challenging group of lesions, mitotic activity, but not immunohistochemical labelling for p16 or bcl-2, correlates with diagnostic category. While a number of genes potentially involved in the genesis of sebaceous neoplasia were uncovered, any molecular differences between the histological diagnostic categories remain unclear., (Copyright © 2016 Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
19. Naevoid hyperkeratosis of the nipple/areola with mycosis fungoides-like changes.
- Author
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Vagaja NN, Meddings-Blaskett O, Wood BA, and Harvey NT
- Subjects
- Adult, Diagnosis, Differential, Female, Humans, Keratosis diagnosis, Mycosis Fungoides diagnosis
- Published
- 2016
- Full Text
- View/download PDF
20. Paediatric melanoma.
- Author
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Wood BA
- Subjects
- Adolescent, Child, Humans, Melanoma diagnosis, Nevus, Epithelioid and Spindle Cell diagnosis, Nevus, Pigmented diagnosis, Skin pathology, Skin Neoplasms diagnosis, Melanoma, Cutaneous Malignant, Melanoma epidemiology, Nevus, Epithelioid and Spindle Cell epidemiology, Nevus, Pigmented epidemiology, Skin Neoplasms epidemiology
- Abstract
Cutaneous melanoma occurs only rarely in children under 10 years of age. Mimics of melanoma, including Spitz naevi and proliferative nodules in congenital melanocytic naevi are much more frequent in this age group. Melanoma arising in congenital melanocytic naevus is uncommon, but can show aggressive behaviour. Although spitzoid lesions constitute the majority of 'diagnostically challenging' cases, they are an uncommon cause of mortality in this age group. Among lesions with undoubted metastatic potential, there are biologically distinct tumours which differ significantly in behaviour from the common types of melanoma seen in adults. In patients over 10 years of age and increasingly into the late adolescent years, melanoma is a relatively common neoplasm. Just as in adult patients, care should be taken to exclude melanoma mimics. Particular care is warranted in this older age group in the assessment of lesions with spitzoid morphology as there is significant potential for both over-and under-diagnosis., (Copyright © 2015 The Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
21. Pleomorphic dermal sarcoma with osteosarcoma-like and chondrosarcoma-like elements.
- Author
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Ardakani NM, Pearce R, and Wood BA
- Subjects
- Aged, Bone Neoplasms diagnosis, Cell Differentiation, Chondrosarcoma diagnosis, Humans, Immunohistochemistry, Male, Nose pathology, Osteosarcoma diagnosis, Skin pathology, Skin Neoplasms diagnosis, Bone Neoplasms pathology, Chondrosarcoma pathology, Osteosarcoma pathology, Skin Neoplasms pathology
- Published
- 2016
- Full Text
- View/download PDF
22. BAP1 deficient malignant melanoma arising from the intradermal component of a congenital melanocytic naevus.
- Author
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Ardakani NM, Palmer DL, and Wood BA
- Subjects
- Aged, Humans, Male, Nevus, Pigmented genetics, Melanoma genetics, Melanoma pathology, Nevus, Pigmented pathology, Skin Neoplasms genetics, Skin Neoplasms pathology, Tumor Suppressor Proteins genetics, Ubiquitin Thiolesterase genetics
- Published
- 2015
- Full Text
- View/download PDF
23. Cutaneous ciliated cyst of the scrotum.
- Author
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Swarbrick N, Harvey NT, and Wood BA
- Subjects
- Adolescent, Humans, Immunohistochemistry, Male, Orchiopexy, Cilia pathology, Cysts pathology, Scrotum pathology, Skin Diseases pathology
- Published
- 2015
- Full Text
- View/download PDF
24. Follicular porokeratosis of the nose: two further cases of an emerging variant of porokeratosis.
- Author
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Kim J, Wood BA, and Harvey NT
- Subjects
- Adult, Biopsy, Female, Humans, Male, Porokeratosis diagnosis, Nose pathology, Porokeratosis pathology, Skin pathology
- Published
- 2015
- Full Text
- View/download PDF
25. Superficial CD34-positive fibroblastic tumour: report of two new cases.
- Author
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Hendry SA, Wong DD, Papadimitriou J, Robbins P, and Wood BA
- Subjects
- Adult, Antigens, CD34 metabolism, Female, Humans, Immunohistochemistry methods, Male, Neoplasms metabolism, Fibroblasts pathology, Neoplasms pathology
- Published
- 2015
- Full Text
- View/download PDF
26. CD117 and CD43 are useful adjuncts in the distinction of adenoid cystic carcinoma from adenoid basal cell carcinoma.
- Author
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Dessauvagie BF and Wood BA
- Subjects
- Adult, Aged, Aged, 80 and over, Biomarkers, Tumor metabolism, Carcinoma, Adenoid Cystic metabolism, Carcinoma, Adenoid Cystic pathology, Carcinoma, Basal Cell metabolism, Carcinoma, Basal Cell pathology, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Skin Neoplasms metabolism, Skin Neoplasms pathology, Young Adult, Carcinoma, Adenoid Cystic diagnosis, Carcinoma, Basal Cell diagnosis, Leukosialin metabolism, Proto-Oncogene Proteins c-kit metabolism, Skin Neoplasms diagnosis
- Abstract
Distinction of cutaneous adenoid cystic carcinoma (ACC) from adenoid basal cell carcinoma (BCC) is an occasional diagnostic dilemma in dermatopathology.We examined the immunohistochemical staining patterns with CD117 and CD43 in ACCs and BCCs, including BCCs with an adenoid growth pattern, to determine whether a combination of these markers can assist in the differential diagnosis.Fifteen cases each of ACC and BCC, including seven BCCs with a partial or entirely adenoid growth pattern were immunohistochemically stained for CD117 and CD43. The stains were interpreted semi-quantitatively.Staining for CD43 and CD117 was significantly more common in ACC than in BCC. Forty percent of ACCs showed staining for CD43, while no cases of BCC were positive. CD117 was positive in all cases of ACC, with 93% showing moderate or strong staining. BCC were less frequently positive, with only 20% of cases showing labelling of weak or moderate intensity.Immunohistochemical positivity for CD117 and CD43 are likely to be helpful adjuncts in the separation of cutaneous ACC from adenoid BCC.
- Published
- 2015
- Full Text
- View/download PDF
27. Purpuric exanthem caused by Ross River virus infection.
- Author
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Allanson B, Harvey NT, Beaton PJ, and Wood BA
- Subjects
- Female, Humans, Middle Aged, Ross River virus, Alphavirus Infections complications, Exanthema virology, Purpura virology
- Published
- 2015
- Full Text
- View/download PDF
28. Merkel cell polyomavirus and p63 status in Merkel cell carcinoma by immunohistochemistry: Merkel cell polyomavirus positivity is inversely correlated with sun damage, but neither is correlated with outcome.
- Author
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Dabner M, McClure RJ, Harvey NT, Budgeon CA, Beer TW, Amanuel B, and Wood BA
- Subjects
- Adult, Aged, Aged, 80 and over, Carcinoma, Merkel Cell metabolism, Carcinoma, Merkel Cell virology, Cohort Studies, Female, Follow-Up Studies, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Male, Merkel cell polyomavirus immunology, Middle Aged, Polyomavirus Infections metabolism, Polyomavirus Infections virology, Prognosis, Skin Neoplasms metabolism, Tumor Virus Infections metabolism, Tumor Virus Infections virology, Western Australia, Biomarkers, Tumor metabolism, Carcinoma, Merkel Cell pathology, Membrane Proteins metabolism, Merkel cell polyomavirus isolation & purification, Polyomavirus Infections pathology, Skin Neoplasms pathology, Tumor Virus Infections pathology
- Abstract
The aim of this study was to determine the frequency of Merkel cell polyomavirus (MPyV) and p63 positivity by immunohistochemistry in a large cohort of primary Merkel cell carcinoma (MCC) from a region with high rates of actinic damage. We also aimed to determine whether there is any relationship between these markers and histological correlates of chronic sun exposure and to identify whether these markers have prognostic significance in our population. Ninety-five cases of primary cutaneous MCC were identified and stained with immunohistochemical markers for MPyV and p63. The presence of solar elastosis and squamous dysplasia in the overlying/adjacent skin were recorded as markers of actinic damage. Follow up data were obtained from the Western Australian Cancer Registry. MPyV was detected by immunohistochemistry in 23% of cases. There was a statistically significantly lower rate of positivity in tumours associated with markers of chronic sun damage as assessed by the presence of solar elastosis and squamous dysplasia. There was no association with overall or disease specific survival. p63 positivity was detected in 17% of cases. There was no association with markers of actinic damage or with overall or disease specific survival.Our data demonstrate a significant difference in rates of immunohistochemical positivity for MPyV between MCC in sun-damaged and non-sun-damaged sites. This may go some way to explaining previously identified geographical differences. When compared with a number of studies from Europe and North America, p63 positivity is less common in our population and does not show the strong prognostic significance that has been found in these other regions.
- Published
- 2014
- Full Text
- View/download PDF
29. Histopathological features associated with application of black salve to cutaneous lesions: a series of 16 cases and review of the literature.
- Author
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Leecy TN, Beer TW, Harvey NT, Kumarasinghe SP, McCallum D, Yu LL, and Wood BA
- Subjects
- Administration, Cutaneous, Adult, Carcinoma, Basal Cell drug therapy, Complementary Therapies, Female, Humans, Male, Melanoma drug therapy, Middle Aged, Nevus, Pigmented drug therapy, Phytotherapy, Plant Extracts therapeutic use, Retrospective Studies, Sanguinaria, Self Medication, Skin Neoplasms drug therapy, Carcinoma, Basal Cell pathology, Melanoma pathology, Nevus, Pigmented pathology, Skin Neoplasms pathology
- Abstract
Aims: To document the histopathological features of self-treatment of cutaneous lesions with the escharotic agent black salve., Methods: Retrospective review of cutaneous lesions treated with black salve retrieved from the files of four pathology practices in Western Australia and review of the published literature., Results: 16 lesions from 11 patients who self administered black salve for the treatment of skin lesions were reviewed. Clinical diagnoses at the time of biopsy included scar, keloid scar, pseudomelanoma, basal cell carcinoma, squamous cell carcinoma and cutaneous necrosis. Histopathological features identified in our series included scarring, granulomatous inflammation, implanted foreign material, reactive stromal atypia and suppurative necrosis. Residual neoplasia was present in two of 16 cases, including a basal cell carcinoma and a melanocytic naevus. An additional 13 lesions in 10 patients were identified in the medical literature, including cases with poor cosmetic outcomes and cases of malignant tumours masked by uncontrolled escharotic treatment., Conclusions: Availability of black salve through easily accessible internet sites appears to be associated with persisting use of this agent for the self-management of cutaneous lesions. Awareness of the potential complications and range of histopathological features associated with self-administration of escharotic agents is of importance to dermatologists and histopathologists.
- Published
- 2013
- Full Text
- View/download PDF
30. Interobserver variability in the diagnosis of circumscribed sebaceous neoplasms of the skin.
- Author
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Harvey NT, Budgeon CA, Leecy T, Beer TW, Kattampallil J, Yu L, Van Vliet C, Muirhead R, Sparrow S, Swarbrick N, and Wood BA
- Subjects
- Adenocarcinoma, Sebaceous classification, Aged, Aged, 80 and over, Dermatology standards, Female, Humans, Male, Middle Aged, Observer Variation, Pathology standards, Skin Neoplasms classification, Adenocarcinoma, Sebaceous diagnosis, Skin Neoplasms diagnosis
- Abstract
Aims: Separation of sebaceous adenoma, sebaceoma and well differentiated sebaceous carcinoma is a clinically important distinction which relies on a number of subjective criteria. In routine practice we had noted significant interobserver variability in the classification of these lesions. This study sought to determine the degree of interobserver variability between general surgical pathologists and dermatopathologists in the diagnosis of well differentiated cutaneous sebaceous neoplasms., Methods: We circulated 61 examples of well circumscribed cutaneous sebaceous neoplasms to nine pathologists, including dermatopathologists and general surgical pathologists who were asked to submit a diagnosis for each case. Fleiss' kappa statistic was used for assessment of interobserver agreement., Results: We found that only seven cases (11%) had consensus agreement across all nine pathologists. Many cases had multiple diagnoses suggested, with three or more submitted diagnoses in 26 cases (43%), while 38 cases (62%) were diagnosed as sebaceous carcinoma by at least one pathologist. There was marked variability amongst the individual pathologists in the proportion of cases diagnosed as carcinoma, ranging from 5% to 57% of cases. Fleiss' kappa statistic for all pathologists across all diagnostic categories was 0.44, amounting to only fair to moderate agreement., Conclusions: These data indicate that there is substantial interobserver variability in the diagnosis of well circumscribed sebaceous neoplasms. This was seen in both the separation of benign and malignant lesions, as well as in the classification of the benign entities. This interobserver variability is likely to have significant clinical implications in terms of potential for over- or under-treatment, as well as in selection of cases for mismatch repair protein evaluation.
- Published
- 2013
- Full Text
- View/download PDF
31. Desmoplastic melanoma: recent advances and persisting challenges.
- Author
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Wood BA
- Subjects
- Biomarkers, Tumor metabolism, Biopsy, Diagnosis, Differential, Humans, Melanoma pathology, Prevalence, Skin metabolism, Skin pathology, Skin Neoplasms pathology, Melanoma classification, Melanoma diagnosis, Skin Neoplasms classification, Skin Neoplasms diagnosis
- Abstract
Desmoplastic melanoma is an uncommon variant of melanoma which presents significant challenges to the clinician and histopathologist. In particular, many cases show a bland 'fibroblastic' appearance, mimicking scar and a range of other benign proliferations. This diagnosis can be particularly problematic in small biopsy specimens, a difficulty exacerbated by an immunoprofile which is typically negative for a number of conventional melanocytic markers. The clinical and histological features of desmoplastic melanoma are reviewed, as are the differential diagnoses and some newer techniques which may contribute to assessment of these lesions. In recent years it has become clear that subclassification of desmoplastic melanoma into pure and mixed variants has clinical significance and it is suggested that this classification be employed in routine practice.
- Published
- 2013
- Full Text
- View/download PDF
32. An 'inflammatory' variant of solar purpura: a simulant of leukocytoclastic vasculitis and neutrophilic dermatoses.
- Author
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Wood BA and LeBoit PE
- Subjects
- Aged, Diagnosis, Differential, Disease Progression, Female, Humans, Incidence, Inflammation pathology, Male, Middle Aged, Purpura pathology, Retrospective Studies, Skin pathology, Skin Diseases epidemiology, Skin Diseases pathology, Sweet Syndrome epidemiology, Sweet Syndrome pathology, Vasculitis, Leukocytoclastic, Cutaneous epidemiology, Vasculitis, Leukocytoclastic, Cutaneous pathology, Neutrophils pathology, Purpura classification, Purpura diagnosis, Skin Diseases diagnosis, Sweet Syndrome diagnosis, Vasculitis, Leukocytoclastic, Cutaneous diagnosis
- Abstract
Aims: To study the clinical and pathological features of cases of apparent solar purpura, with attention to the recently described phenomenon of inflammatory changes within otherwise typical lesions., Methods: We studied 95 cases diagnosed as solar purpura and identified 10 cases (10.5%) in which significant neutrophilic inflammation was present, potentially simulating a leukocytoclastic vasculitis or neutrophilic dermatosis. An additional three cases were identified in subsequent routine practice. The clinical features, including follow-up for subsequent development of vasculitis and histological features were studied., Results: In all cases the histological features were typical of solar purpura, with the exception of inflammatory changes, typically associated with clefting of elastotic stroma. Clinical follow-up information was available for all patients and none developed subsequent evidence of a cutaneous or systemic vasculitis or neutrophilic dermatosis., Conclusions: Inflammatory changes appear to be more frequent in solar purpura than is generally recognised. Awareness of this histological variation and correlation with the clinical findings and evolution is important in avoiding misdiagnosis.
- Published
- 2013
- Full Text
- View/download PDF
33. Immunohistochemical staining for p16 is a useful adjunctive test in the diagnosis of Bowen's disease.
- Author
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Harvey NT, Leecy T, and Wood BA
- Subjects
- Biomarkers, Tumor metabolism, Bowen's Disease metabolism, Diagnosis, Differential, Humans, Immunohistochemistry methods, Keratosis, Actinic metabolism, Keratosis, Seborrheic metabolism, Skin Neoplasms metabolism, Bowen's Disease diagnosis, Cyclin-Dependent Kinase Inhibitor p16 metabolism, Keratosis, Actinic diagnosis, Keratosis, Seborrheic diagnosis, Skin Neoplasms diagnosis
- Abstract
Aims: The aim of this study was to document the pattern of immunohistochemical staining seen with p16 (INK4a) in actinic keratosis, Bowen's disease and seborrhoeic keratosis., Methods: We gathered 20 examples each of actinic keratosis, Bowen's disease and seborrheic keratosis. The cases were stained for p16 using standard immunohistochemical techniques, and the staining patterns were categorised into one of five different patterns., Results: All cases of Bowen's disease as defined in our practice showed strong positive staining in all abnormal cells, and 95% of these cases showed a distinctive pattern of sparing in a layer of palisaded basal cells. None of the actinic keratoses or seborrheic keratoses, as defined by our morphological criteria, showed this distinctive pattern., Conclusions: Bowen's disease, as we define the term, shows a distinctive, repeatable pattern of staining with p16, characterised by moderate to strong staining of all abnormal cells with sparing of a layer of basal cells. This pattern is not seen in actinic keratoses or in seborrheic keratoses. Thus immunohistochemistry for p16 is a useful adjunctive test in the differential diagnosis of these lesions.
- Published
- 2013
- Full Text
- View/download PDF
34. Desmoplastic trichoepitheliomas with perineural involvement.
- Author
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Harvey NT, Leecy T, Beer TW, and Wood BA
- Subjects
- Adenoma diagnosis, Adolescent, Biomarkers, Tumor metabolism, Carcinoma, Basal Cell diagnosis, Diagnosis, Differential, Female, Humans, Keratin-20 metabolism, Neoplasm Invasiveness, Neoplasm Recurrence, Local, Neoplasms, Adnexal and Skin Appendage metabolism, Neoplasms, Adnexal and Skin Appendage surgery, Peripheral Nerves metabolism, Skin Neoplasms metabolism, Skin Neoplasms surgery, Treatment Outcome, Young Adult, Neoplasms, Adnexal and Skin Appendage diagnosis, Peripheral Nerves pathology, Skin Neoplasms diagnosis
- Published
- 2013
- Full Text
- View/download PDF
35. Histopathological features of cutaneous drug reactions to vemurafenib: a report of two cases.
- Author
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Dabner M, Harvey NT, Soma A, and Wood BA
- Subjects
- Adult, Biopsy, Humans, Indoles therapeutic use, Male, Melanoma pathology, Middle Aged, Prospective Studies, Skin drug effects, Skin pathology, Skin Neoplasms pathology, Sulfonamides therapeutic use, Vemurafenib, Drug Eruptions pathology, Indoles adverse effects, Melanoma drug therapy, Proto-Oncogene Proteins B-raf antagonists & inhibitors, Skin Neoplasms drug therapy, Sulfonamides adverse effects
- Published
- 2012
- Full Text
- View/download PDF
36. Transported papillary lesions of the breast in axillary lymph nodes: a report of two cases.
- Author
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Hardie M, Sterrett G, Snowball B, and Wood BA
- Subjects
- Aged, Axilla, Biopsy, Fine-Needle, Carcinoma, Ductal, Breast pathology, Female, Humans, Immunohistochemistry, Neoplasm Recurrence, Local pathology, Breast Neoplasms pathology, Lymph Nodes pathology, Neoplasm Seeding, Papilloma, Intraductal pathology
- Published
- 2010
- Full Text
- View/download PDF
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