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4. TGF-βRIl, BAX, IGFIIR, caspase-5, hMSH3and hMSH6alterations are not associated with microsatellite instability or p53mutations in invasive urothelial carcinoma of the urinary bladder

Author

Saetta, Angelica A., Korkolopoulou, Penelope, Karlou, Maria, Levidou, Georgia, Goudopoulou, Athina, Thymara, Irene, Stamatelli, Angeliki, Tzivras, Michalis, Michalopoulos, Nikolaos V., Thomas-Tsagli, Euphemia, and Patsouris, Efstratios

Abstract

The aim of this study was to determine the potential synchronous contribution of alterations in TGF-βiRII, BAX, IGFIIR, caspase-5, hMSH3and hMSH6genes to the development and clinical outcome of bladder cancer, in relation to p53mutations, microsatellite status and hMLHI/ hMSH2 expression.

Published
2007
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5. TGF-betaRII, BAX, IGFIIR, caspase-5, hMSH3 and hMSH6 alterations are not associated with microsatellite instability or p53 mutations in invasive urothelial carcinoma of the urinary bladder.

Author

Saetta AA, Korkolopoulou P, Karlou M, Levidou G, Goudopoulou A, Thymara I, Stamatelli A, Tzivras M, Michalopoulos NV, Thomas-Tsagli E, and Patsouris E

Subjects
Adult, Aged, Aged, 80 and over, Caspases genetics, DNA, Neoplasm genetics, DNA-Binding Proteins genetics, Female, Gene Expression Regulation, Neoplastic, Humans, Male, Microsatellite Instability, Middle Aged, Multivariate Analysis, MutS Homolog 3 Protein, Mutation genetics, Neoplasm Invasiveness, Protein Serine-Threonine Kinases genetics, Receptor, IGF Type 2 genetics, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta genetics, Survival Analysis, Tumor Suppressor Protein p53 genetics, Urinary Bladder Neoplasms pathology, Urothelium metabolism, Urothelium pathology, bcl-2-Associated X Protein genetics, Caspases metabolism, DNA-Binding Proteins metabolism, Protein Serine-Threonine Kinases metabolism, Receptor, IGF Type 2 metabolism, Receptors, Transforming Growth Factor beta metabolism, Urinary Bladder Neoplasms metabolism, bcl-2-Associated X Protein metabolism
Abstract

Aim: The aim of this study was to determine the potential synchronous contribution of alterations in TGF-betaRII, BAX, IGFIIR, caspase-5, hMSH3 and hMSH6 genes to the development and clinical outcome of bladder cancer, in relation to p53 mutations, microsatellite status and hMLH1/hMSH2 expression., Methods: Molecular biology techniques as well as immunohistochemistry were applied in 69 samples from patients with urothelial carcinoma., Results: Microsatellite alterations were observed in TGF-betaRII(A)(10 )(16%) and BAX(G)(8 )(3%), irrespective of the presence of p53 mutations, but not in IGFIIR(G)(8), caspase-5(A)(10, ) hMSH3(A)(8) and hMSH6(C)(8). A statistically significant correlation could be found only between hMLH1 expression and the presence of microsatellite instability (Fisher's exact test, p = 0,013). Survival analysis indicated that apart from grade and T-category, hMLH1 expression was the only parameter significantly affecting overall survival (p = 0.021 in univariate and p = 0.015 in multivariate analysis) and recurrence-free survival (p = 0.0463 in univariate and p = 0.022 in multivariate analysis)., Conclusions: We conclude that alterations of the examined target genes of MSI are rare in urinary bladder carcinoma and they are not associated with microsatellite instability or the presence of p53 mutations.

Published
2007
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