1. A novel hypermucoviscous Klebsiella pneumoniae ST3994-K2 clone belonging to Clonal Group 86.
- Author
-
Cerdeira L, Nakamura-Silva R, Oliveira-Silva M, Sano E, Esposito F, Fuga B, Moura Q, Miranda CES, Wyres K, Lincopan N, and Pitondo-Silva A
- Subjects
- Genome, Bacterial, Genomics methods, Humans, Klebsiella pneumoniae classification, Microbial Sensitivity Tests, Multilocus Sequence Typing, Phenotype, Phylogeny, Virulence genetics, Virulence Factors genetics, Whole Genome Sequencing, Bacterial Physiological Phenomena, Klebsiella Infections microbiology, Klebsiella pneumoniae physiology
- Abstract
Emergent hypervirulent Klebsiella pneumoniae has been responsible for severe diseases, representing a serious threat to public health. We report the whole-genome sequencing of a novel ST3994-K2 clone, a single locus variant of ST86 K2, which is considered a worrying hypervirulent clone that emerged in several parts of the world. The strain K. pneumonia Kpi144 was isolated in 2013 from a blood culture of a 69-year-old male patient admitted to a tertiary hospital in Teresina, state of Piauí, northeastern Brazil. The strain was susceptible to 41 antibiotics tested, presented hypermucoviscous phenotype and a virulent behavior was observed in the Galleria mellonella infection model. Moreover, the virulome showed several virulence genes. To the best of our knowledge, this is the first worldwide report of a novel ST3994-K2 K. pneumoniae clone, an SLV of ST86 K2, which is considered a worrying virulent clone that has emerged in several parts of the world, including South America and Brazil., (© The Author(s) 2021. Published by Oxford University Press on behalf of FEMS. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2021
- Full Text
- View/download PDF