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Introduction: Doxorubicin leads to lipid profile disorders. The aim of this study was to evaluate the effect of hydroalcoholic extract of ginger (Zingiber officinale) on the lipid profile of male rats after receiving doxorubicin. Material and Methods: In this experimental study, 63 adult male rats were divided into 7 groups of 9: control group, sham group: received distilled water. Experimental group 1 received 20 mg / kg/ bw doxorubicin intraperitoneally, experimental groups 2 and 3 received 300 mg / kg/ bw and 600 mg / kg/ bw of hydroalcoholic extract of ginger orally for 2 months, respectively. Experimental groups 5 and 4 received doxorubicin and hydroalcoholic extract of ginger (20 mg / kg/ bw + 300 mg / kg/ bw) and (20 mg / kg/ bw + 600 mg / kg/ bw), respectively for 2 months. After the end of the experimental period, blood samples were collected and serum levels of lipid profiles were measured. Data were analyzed using SPSS software version 19 and the groups were compared by ANOVA and Tukey test. Results: Serum levels of triglyceride, total cholesterol, and LDL cholesterol were significantly increased in the doxorubicin group compared to the control group. Serum HDL cholesterol levels in the doxorubicin group showed a significant decrease compared to the control group. Serum levels of triglycerides, total cholesterol, LDL cholesterol and HDL cholesterol in the groups (20 mg / kg/ bw + 300 mg / kg/ bw) and (20 mg / kg/ bw + 600 mg / kg/ bw) showed a significant decrease compared to the doxorubicin group (P <0.05). Conclusion: Ginger hydroalcoholic extract probably improved its lipid profile after receiving doxorubicin due to its antioxidant properties. [ABSTRACT FROM AUTHOR]

Introduction: Today, hyperlipidemia, followed by atherosclerosis, leads to cardiovascular diseases and even death in most countries. Antioxidants can reduce blood cholesterol and risks of cardiovascular diseases. Given that Origanum vulgar is full of antioxidants, we aimed to study the effects of Origanum vulgare extract (OVE) on serum lipid profile and weight. Methods and Materials: In this study, 28 male Wistar rats were divided into four groups (n=7). The control group received distilled water, three experimental groups received the hydroalcoholic OVE at different doses of 50, 75 and 100 mg/kg, respectively. Pretreatment with OVE was performed for 30 days orally through gavage. Two hours after the last gavage, the rats were weighed, then blood samples were collected to measure serum levels of cholesterol, triglyceride, low density lipoprotein (LDL) and high density lipoprotein (HDL). The data were analyzed using one-way ANOVA in SPSS. Results: The results of the current study showed that OVE reduced the levels of cholesterol, triglycerides, low density lipoprotein and increased the level of high density lipoprotein in the three groups receiving OVE (50, 75 and 100 mg/kg) compared to the control group. OVE did not cause changes in rats' weight. Conclusion: It appears that OVE can exert a protective effect against cardiovascular diseases by reducing the levels of cholesterol, triglyceride, low density lipoprotein and increasing high density lipoprotein. [ABSTRACT FROM AUTHOR]