1. Olfactory function combined with morphology distinguishes Parkinson's disease
- Author
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Mikihiro Yamazaki, Kimiteru Ito, Satoshi Matsushima, Yu Kono, Keiko Bono, Renpei Sengoku, Kenichi Sakuta, Yasuyuki Iguchi, Tsutomu Kamiyama, Hidetaka Mitsumura, Shinji Miyagawa, Teppei Komatsu, and Soichiro Mochio
- Subjects
Adult ,Male ,medicine.medical_specialty ,Pathology ,Parkinson's disease ,Unified Parkinson's disease rating scale ,Gastroenterology ,Progressive supranuclear palsy ,Olfaction Disorders ,Atrophy ,Internal medicine ,medicine ,Corticobasal degeneration ,Humans ,Aged ,Aged, 80 and over ,medicine.diagnostic_test ,Parkinsonism ,Dysautonomia ,Magnetic resonance imaging ,Parkinson Disease ,Organ Size ,Middle Aged ,medicine.disease ,Olfactory Bulb ,Neurology ,Odorants ,Female ,Neurology (clinical) ,Geriatrics and Gerontology ,medicine.symptom ,Psychology - Abstract
Objective This study aimed to examine whether the volume of the olfactory bulbs and tracts (OB & T) on magnetic resonance imaging (MRI) is useful for differentiating Parkinson's disease (PD) from PD-related disorders. Methods The study group comprised 13 patients with PD, 11 with multiple system atrophy (MSA), five with progressive supranuclear palsy, and five with corticobasal degeneration (PSP/CBD). All patients were evaluated using the odor stick identification test for Japanese (OSIT-J), 123I-meta-iodobenzylguanidine (MIBG) scintigraphy, and brain MRI. OB & T areas on 1-mm-thick coronal images were measured and summed for volumes. We examined relationships between olfactory function and volume, and cardiovascular dysautonomia. We defined the cut-off values for OSIT-J score or MIBG uptake and OB & T volume to discriminate PD from PD-related disorders and calculated the proportional rate of PD in four categorized groups. Results OB & T volume was smaller in PD than in MSA or PSP/CBD (p
- Published
- 2014