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Your search keyword '"Coelho, Adriano C."' showing total 3 results
Start Over Author "Coelho, Adriano C." Journal parasitology
3 results on '"Coelho, Adriano C."'

2. Chemotherapy of leishmaniasis: present challenges.

Author

Karunaweera, Nadira D., Ferreira, Marcelo U., ULIANA, SILVIA R. B., TRINCONI, CRISTIANA T., and COELHO, ADRIANO C.

Subjects
CUTANEOUS leishmaniasis, VISCERAL leishmaniasis, DRUG therapy, DRUG side effects, DRUG resistance, THERAPEUTICS, PROTOZOA
Abstract

SUMMARY: Cutaneous and visceral leishmaniasis are amongst the most devastating infectious diseases of our time, affecting millions of people worldwide. The treatment of these serious diseases rely on a few chemotherapeutic agents, most of which are of parenteral use and induce severe side-effects. Furthermore, rates of treatment failure are high and have been linked to drug resistance in some areas. Here, we reviewed data on current chemotherapy practice in leishmaniasis. Drug resistance and mechanisms of resistance are described as well as the prospects for applying drug combinations for leishmaniasis chemotherapy. It is clear that efforts for discovering new drugs applicable to leishmaniasis chemotherapy are essential. The main aspects on the various steps of drug discovery in the field are discussed. [ABSTRACT FROM AUTHOR]

Published
2018
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3. Chemotherapy of leishmaniasis: present challenges.

Author

Uliana SRB, Trinconi CT, and Coelho AC

Subjects
Animals, Antiprotozoal Agents adverse effects, Antiprotozoal Agents pharmacology, Antiprotozoal Agents therapeutic use, Clinical Trials as Topic, Cricetinae, Disease Models, Animal, Drug Resistance, Multiple genetics, Drug Therapy, Combination methods, Humans, Leishmaniasis, Cutaneous parasitology, Leishmaniasis, Visceral parasitology, Mice, Drug Discovery methods, Leishmania drug effects, Leishmaniasis, Cutaneous drug therapy, Leishmaniasis, Visceral drug therapy, Treatment Failure
Abstract

Cutaneous and visceral leishmaniasis are amongst the most devastating infectious diseases of our time, affecting millions of people worldwide. The treatment of these serious diseases rely on a few chemotherapeutic agents, most of which are of parenteral use and induce severe side-effects. Furthermore, rates of treatment failure are high and have been linked to drug resistance in some areas. Here, we reviewed data on current chemotherapy practice in leishmaniasis. Drug resistance and mechanisms of resistance are described as well as the prospects for applying drug combinations for leishmaniasis chemotherapy. It is clear that efforts for discovering new drugs applicable to leishmaniasis chemotherapy are essential. The main aspects on the various steps of drug discovery in the field are discussed.

Published
2018
Full Text
View/download PDF

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