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The aim of this research was to study the influence of related variety on the economic performance of Spanish provinces during the international crisis (2009–2013) and the post‐crisis period (2014–2018), with the goal of contributing to assess the validity of the skill‐relatedness approach. The research is based on labor flows in a sample of more than one million affiliated workers. Our results confirmed the influence of related variety on the growth of GDP and employment in knowledge‐based industries, in protecting against unemployment, as well as on the creation of new firms, although with marked differences according to the economic cycle. Robustness issues and possible lines of progress using this novel methodology are also discussed. [ABSTRACT FROM AUTHOR]