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4. Loss-of-function variant in chymotrypsin like elastase 3B (CELA3B) is associated with non-alcoholic chronic pancreatitis

Author

Tóth, Andrea, Demcsák, Alexandra, Zankl, Florence, Oracz, Grzegorz, Unger, Lara Sophie, Bugert, Peter, Laumen, Helmut, Párniczky, Andrea, Hegyi, Péter, Rosendahl, Jonas, Gambin, Tomasz, Płoski, Rafał, Koziel, Dorota, Gluszek, Stanisław, Lindgren, Fredrik, Löhr, J. Matthias, Sahin-Tóth, Miklós, Witt, Heiko, Rygiel, Agnieszka Magdalena, Ewers, Maren, and Hegyi, Eszter

Published
2022
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5. Variants in the pancreatic CUB and zona pellucida-like domains 1 (CUZD1) gene in early-onset chronic pancreatitis - A possible new susceptibility gene

Author

Rygiel, Agnieszka Magdalena, Unger, Lara Sophie, Sörgel, Franziska Lena, Masson, Emmanuelle, Matsumoto, Ryotaro, Ewers, Maren, Chen, Jian-Min, Bugert, Peter, Buscail, Louis, Gambin, Tomasz, Oracz, Grzegorz, Winiewska-Szajewska, Maria, Mianowska, Agnieszka, Poznanski, Jarosław, Kosińska, Joanna, Stawinski, Piotr, Płoski, Rafał, Koziel, Dorota, Gluszek, Stanisław, Laumen, Helmut, Lindgren, Fredrik, Löhr, J. Matthias, Orekhova, Anna, Rebours, Vinciane, Rosendahl, Jonas, Párniczky, Andrea, Hegyi, Péter, Sasaki, Akira, Kataoka, Fumiya, Tanaka, Yu, Hamada, Shin, Sahin-Tóth, Miklós, Hegyi, Eszter, Férec, Claude, Masamune, Atsushi, and Witt, Heiko

Published
2022
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9. Acid suppression therapy, gastrointestinal bleeding and infection in acute pancreatitis – An international cohort study

Author

Demcsák, Alexandra, Soós, Alexandra, Kincses, Lilla, Capunge, Ines, Minkov, Georgi, Kovacheva-Slavova, Mila, Nakov, Radislav, Wu, Dong, Huang, Wei, Xia, Qing, Deng, Lihui, Hollenbach, Marcus, Schneider, Alexander, Hirth, Michael, Ioannidis, Orestis, Vincze, Áron, Bajor, Judit, Sarlós, Patrícia, Czakó, László, Illés, Dóra, Izbéki, Ferenc, Gajdán, László, Papp, Mária, Hamvas, József, Varga, Márta, Kanizsai, Péter, Bóna, Ernő, Mikó, Alexandra, Váncsa, Szilárd, Juhász, Márk Félix, Ocskay, Klementina, Darvasi, Erika, Miklós, Emőke, Erőss, Bálint, Szentesi, Andrea, Párniczky, Andrea, Casadei, Riccardo, Ricci, Claudio, Ingaldi, Carlo, Mastrangelo, Laura, Jovine, Elio, Cennamo, Vincenzo, Marino, Marco V., Barauskas, Giedrius, Ignatavicius, Povilas, Pelaez-Luna, Mario, Rios, Andrea Soriano, Turcan, Svetlana, Tcaciuc, Eugen, Małecka-Panas, Ewa, Zatorski, Hubert, Nunes, Vitor, Gomes, Antonio, Gonçalves, Tiago Cúrdia, Freitas, Marta, Constantino, Júlio, Sá, Milene, Pereira, Jorge, Mateescu, Bogdan, Constantinescu, Gabriel, Sandru, Vasile, Negoi, Ionut, Ciubotaru, Cezar, Negoita, Valentina, Bunduc, Stefania, Gheorghe, Cristian, Barbu, Sorin, Tantau, Alina, Tantau, Marcel, Dumitru, Eugen, Suceveanu, Andra Iulia, Tocia, Cristina, Gherbon, Adriana, Litvin, Andrey, Shirinskaya, Natalia, Rabotyagova, Yliya, Bezmarevic, Mihailo, Hegyi, Péter Jenő, Han, Jimin, Rodriguez-Oballe, Juan Armando, Salas, Isabel Miguel, Comas, Eva Pijoan, Garcia, Daniel de la Iglesia, Cuadrado, Andrea Jardi, Castiñeira, Adriano Quiroga, Chang, Yu-Ting, Chang, Ming-Chu, Kchaou, Ali, Tlili, Ahmed, Kacar, Sabite, Gökbulut, Volkan, Duman, Deniz, Kani, Haluk Tarik, Altintas, Engin, Chooklin, Serge, Chuklin, Serhii, Gougol, Amir, Papachristou, George, and Hegyi, Péter

Published
2020
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10. International Consensus Guidelines for Risk Factors in Chronic Pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club

Author

Hegyi, Péter, Párniczky, Andrea, Lerch, Markus M., Sheel, Andrea R.G., Rebours, Vinciane, Forsmark, Chris E., Del Chiaro, Marco, Rosendahl, Jonas, de-Madaria, Enrique, Szücs, Ákos, Takaori, Kyoichi, Yadav, Dhiraj, Gheorghe, Cristian, Rakonczay, Zoltán, Jr., Molero, Xavier, Inui, Kazuo, Masamune, Atsushi, Fernandez-Del Castillo, Carlos, Shimosegawa, Tooru, Neoptolemos, John P., Whitcomb, David C., and Sahin-Tóth, Miklós

Published
2020
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12. CEL-HYB1 haplotypes confer varying risk for chronic pancreatitis

Author

Berke, Gergő, primary, Sándor, Máté, additional, Ewers, Maren, additional, Erőss, Bálint, additional, Masson, Emmanuelle, additional, Németh, Balázs Csaba, additional, Vincze, Áron, additional, Czakó, László, additional, Sahin-Tóth, Vera, additional, Rygiel, Agnieszka Magdalena, additional, Rosendahl, Jonas, additional, Chen, Jian-Min, additional, Witt, Heiko, additional, Hegyi, Péter, additional, Sahin-Tóth, Miklós, additional, and Hegyi, Eszter, additional

Published
2023
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15. Loss-of-function variant in chymotrypsin like elastase 3B (CELA3B) is associated with non-alcoholic chronic pancreatitis

Author

Andrea Tóth, Alexandra Demcsák, Florence Zankl, Grzegorz Oracz, Lara Sophie Unger, Peter Bugert, Helmut Laumen, Andrea Párniczky, Péter Hegyi, Jonas Rosendahl, Tomasz Gambin, Rafał Płoski, Dorota Koziel, Stanisław Gluszek, Fredrik Lindgren, J. Matthias Löhr, Miklós Sahin-Tóth, Heiko Witt, Agnieszka Magdalena Rygiel, Maren Ewers, and Eszter Hegyi

Subjects
Pancreatic Elastase, Hepatology, Pancreatitis, Chronic, Endocrinology, Diabetes and Metabolism, Mutation, Gastroenterology, Chymotrypsin, Humans, Genetic Predisposition to Disease
Abstract

Genetic alterations in digestive enzymes have been associated with chronic pancreatitis (CP). Recently, chymotrypsin like elastase 3B (CELA3B) emerged as a novel risk gene. Thus, we evaluated CELA3B in two European cohorts with CP.We analyzed all 8 CELA3B exons in 550 German non-alcoholic CP (NACP) patients and in 241 German controls by targeted DNA sequencing. In addition, we analyzed exons 6 and 7 by Sanger sequencing and the c.129+1GA variant by melting curve analysis in 1078 further German controls. As replication cohort, we investigated up to 243 non-German European NACP patients and up to 1665 controls originating from Poland, Hungary, and Sweden. We assessed the cellular secretion and the elastase activity of recombinant CELA3B variants.In the German discovery cohort, we detected a splice-site variant in intron 2, c.129+1GA, in 9/550 (1.64%) CP patients and in 5/1319 (0.38%) controls (P=0.007, OR=4.4, 95% CI=1.5-13.0). In the European replication cohort, this variant was also enriched in patients (9/178 [5.06%]) versus controls (13/1247 [1.04%]) (P=0.001, OR=5.1, 95% CI=2.1-12.0). We did not find the two previously reported codon 90 variants, p.R90C and p.R90L.Our data indicate that CELA3B is a susceptibility gene for CP. In contrast to previous reports suggesting that increased CELA3B activity is associated with CP risk, the splice-site variant identified here is predicted to cause diminished CELA3B expression. How reduced CELA3B function predisposes to pancreatitis remains to be elucidated.

Published
2022

16. Variants in the pancreatic CUB and zona pellucida-like domains 1 (CUZD1) gene in early-onset chronic pancreatitis - A possible new susceptibility gene

Author

Agnieszka Magdalena Rygiel, Lara Sophie Unger, Franziska Lena Sörgel, Emmanuelle Masson, Ryotaro Matsumoto, Maren Ewers, Jian-Min Chen, Peter Bugert, Louis Buscail, Tomasz Gambin, Grzegorz Oracz, Maria Winiewska-Szajewska, Agnieszka Mianowska, Jarosław Poznanski, Joanna Kosińska, Piotr Stawinski, Rafał Płoski, Dorota Koziel, Stanisław Gluszek, Helmut Laumen, Fredrik Lindgren, J. Matthias Löhr, Anna Orekhova, Vinciane Rebours, Jonas Rosendahl, Andrea Párniczky, Péter Hegyi, Akira Sasaki, Fumiya Kataoka, Yu Tanaka, Shin Hamada, Miklós Sahin-Tóth, Eszter Hegyi, Claude Férec, Atsushi Masamune, and Heiko Witt

Subjects
Hepatology, Pancreatitis, Chronic, Endocrinology, Diabetes and Metabolism, Blotting, Western, Gastroenterology, Humans, Membrane Proteins, Genetic Predisposition to Disease, Acinar Cells, Zona Pellucida, Article
Abstract

OBJECTIVE: Non-alcoholic chronic pancreatitis (NACP) frequently develops in the setting of genetic susceptibility associated with alterations in genes that are highly expressed in the pancreas. However, the genetic basis of NACP remains unresolved in a significant number of patients warranting a search for further risk genes. DESIGN: We analyzed CUZD1, which encodes the CUB and zona pellucida-like domains 1 protein that is found in high levels in pancreatic acinar cells. We sequenced the coding region in 1,163 European patients and 2,018 European controls. In addition, we analyzed 297 patients and 1,070 controls from Japan. We analyzed secretion of wild-type and mutant CUZD1 from transfected cells using Western blotting. RESULTS: In the European cohort, we detected 30 non-synonymous variants. Using different prediction tools (SIFT, CADD, PROVEAN, PredictSNP) or the combination of these tools, we found accumulation of predicted deleterious variants in patients (p-value range 0.002–0.013; OR range 3.1–5.2). No association was found in the Japanese cohort, in which 13 non-synonymous variants were detected. Functional studies revealed >50% reduced secretion of 7 variants, however, these variants were not significantly enriched in European CP patients. CONCLUSION: Our data indicate that CUZD1 might be a novel susceptibility gene for chronic pancreatitis. How these variants predispose to pancreatitis remains to be elucidated.

Published
2022

18. Genetic analysis of the bicarbonate secreting anion exchanger SLC26A6 in chronic pancreatitis

Author

Balázs, Anita, Ruffert, Claudia, Hegyi, Eszter, Hritz, István, Czakó, László, Takács, Tamás, Szepes, Zoltán, Németh, Balázs Csaba, Gervain, Judit, Izbéki, Ferenc, Halász, Adrienn, Kelemen, Dezső, Szmola, Richárd, Novák, János, Crai, Stefan, Illés, Anita, Vincze, Áron, Molnár, Zsolt, Varga, Márta, Bod, Barnabás, Farkas, Gyula, Jr., Sümegi, János, Szepes, Attila, Dubravcsik, Zsolt, Lásztity, Natália, Párniczky, Andrea, Hamvas, József, Andorka, Csilla, Veres, Gábor, Szentkereszty, Zsolt, Rakonczay, Zoltán, Jr., Maléth, József, Sahin-Tóth, Miklós, Rosendahl, Jonas, and Hegyi, Péter

Published
2015
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19. Metabolic associated fatty liver disease is associated with a more severe acute pancreatitis: a prospective cohort analysis of 2053 cases

Author

Vancsa, Szilard, primary, Sipos, Z., additional, Ocskay, K., additional, Juhasz, F., additional, Földi, M., additional, Vincze, A., additional, Sarlós, P., additional, Bajor, J., additional, Izbéki, F., additional, Papp, M., additional, Vitális, Z., additional, Hamvas, J., additional, Czakó, L., additional, Faluhelyi, N., additional, Farkas, O., additional, Miklós, E., additional, Mikó, A., additional, Hegyi, P. Jenő, additional, Macarie, M., additional, Galeev, S., additional, Maldonado, E. Ramirez, additional, Sallinen, V., additional, Török, I., additional, Mickevicius, A., additional, Párniczky, A., additional, Szentesi, A., additional, Pár, G., additional, Nagy, R., additional, Erőss, B., additional, and Hegyi, P., additional

Published
2022
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20. Mouse model suggests limited role for human mesotrypsin in pancreatitis

Author

Dóra Mosztbacher and Miklós Sahin-Tóth

Subjects
Trypsinogen, Endocrinology, Diabetes and Metabolism, Mutant, medicine.disease_cause, Article, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Acinar cell, Animals, Chymotrypsin, Humans, Medicine, Trypsin, Glycoproteins, Inflammation, Serine protease, Mutation, Hepatology, biology, business.industry, Gastroenterology, Prostatic Secretory Proteins, medicine.disease, Molecular biology, Mice, Inbred C57BL, Disease Models, Animal, Gene Expression Regulation, Pancreatitis, chemistry, Trypsin Inhibitor, Kazal Pancreatic, 030220 oncology & carcinogenesis, biology.protein, Acute pancreatitis, 030211 gastroenterology & hepatology, business, Ceruletide, medicine.drug
Abstract

Mesotrypsin is a low-abundance human trypsin isoform with a unique evolutionary mutation that conferred resistance to trypsin inhibitors and restricted substrate specificity. Mesotrypsin degrades the serine protease inhibitor Kazal type 1 (SPINK1) and thereby might increase risk for pancreatitis. Here, we report a mouse model designed to test the role of mesotrypsin in pancreatitis. We introduced the human mesotrypsin evolutionary signature mutation into mouse cationic trypsinogen (isoform T7), resulting in a Gly to Arg change at the corresponding position 199. In biochemical experiments using purified proteins, the p.G199R T7 mutant recapitulated all salient features of human mesotrypsin. T7G199R mice developed normally with no spontaneous pancreatitis or other obvious phenotypic changes. Cerulein-induced acute pancreatitis in C57BL/6N and T7G199R mice showed similar severity with respect to inflammatory parameters and acinar cell necrosis while plasma amylase activity was higher in T7G199R mice. Neither SPINK1 degradation nor elevated intrapancreatic trypsin activation was apparent in T7G199R mice. The results indicate that in T7G199R mice the newly created mesotrypsin-like activity has no significant impact on cerulein-induced pancreatitis. The observations suggest that human mesotrypsin is unimportant for pancreatitis; a notion that is consistent with published human genetic studies.

Published
2021

21. Measuring digestive protease activation in the mouse pancreas

Author

Alexandra Demcsák, Dóra Mosztbacher, and Miklós Sahin-Tóth

Subjects
Male, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Intraperitoneal injection, Peptide, Sodium Chloride, Article, Mice, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Chymotrypsin, Trypsin, Bovine serum albumin, Pancreas, chemistry.chemical_classification, Protease, Hepatology, biology, business.industry, Gastroenterology, Substrate (chemistry), Serum Albumin, Bovine, medicine.disease, Molecular biology, Enzyme Activation, Mice, Inbred C57BL, Pancreatitis, chemistry, 030220 oncology & carcinogenesis, biology.protein, Female, 030211 gastroenterology & hepatology, business, Ceruletide, Peptide Hydrolases, medicine.drug
Abstract

Intrapancreatic activation of digestive proteases, trypsin and chymotrypsin in particular, is a hallmark of pancreatitis. In experimental rodent models, protease activation is routinely measured from pancreatic homogenates using fluorogenic peptide substrates. Here we investigated the optimal conditions for the determination of intrapancreatic trypsin and chymotrypsin activation elicited by a single intraperitoneal injection of cerulein in C57BL/6N mice. We found that these protease assays were significantly improved by using lower amounts of pancreatic homogenate and exclusion of bovine serum albumin from the assay buffer. Furthermore, pancreatic homogenates had to be freshly prepared and assayed; as freezing and thawing stimulated protease activation. Finally, replacement of the widely used Boc-Gln-Ala-Arg-AMC trypsin substrate with Z-Gly-Pro-Arg-AMC reduced the background activity in saline-treated control mice and thereby increased the extent of cerulein-induced trypsin activation. Using the optimized protocol, we reproducibly measured 20-fold and 200-fold increases in the intrapancreatic trypsin and chymotrypsin activity, respectively, in mice given cerulein.

Published
2020

22. Metabolic associated fatty liver disease is associated with a more severe acute pancreatitis: a prospective cohort analysis of 2053 cases

Author

S. Váncsa, Z. Sipos, R. Nagy, K. Ocskay, F. Juhász, M. Földi, Á. Vincze, P. Sarlós, J. Bajor, F. Izbéki, M. Papp, Z. Vitális, J. Hamvas, L. Czakó, N. Faluhelyi, O. Farkas, E. Miklós, A. Mikó, H. Jeno-Péter, M. Macarie, S. Galeev, E. Ramirez Maldonado, V. Sallinen, I. Török, A. Mickevicius, B. Eross, A. Párniczky, A. Szentesi, G. Pár, and P. Hegyi

Subjects
Hepatology, Endocrinology, Diabetes and Metabolism, Gastroenterology
Published
2022

25. Metabolic associated fatty liver disease is associated with a more severe acute pancreatitis: A prospective cohort analysis of 2053 cases

Author

Váncsa, S., primary, Sipos, Z., additional, Nagy, R., additional, Ocskay, K., additional, Juhász, F., additional, Földi, M., additional, Vincze, Á., additional, Sarlós, P., additional, Bajor, J., additional, Izbéki, F., additional, Papp, M., additional, Vitális, Z., additional, Hamvas, J., additional, Czakó, L., additional, Faluhelyi, N., additional, Farkas, O., additional, Miklós, E., additional, Mikó, A., additional, Jeno-Péter, H., additional, Macarie, M., additional, Galeev, S., additional, Maldonado, E. Ramirez, additional, Sallinen, V., additional, Török, I., additional, Mickevicius, A., additional, Eross, B., additional, Párniczky, A., additional, Szentesi, A., additional, Pár, G., additional, and Hegyi, P., additional

Published
2021
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26. Recurrent acute pancreatitis prevention by the elimination of alcohol and cigarette smoking (reappear): Protocol of a randmozied controlled trial and a cohort study

Author

Ocskay, K., primary, Juhász, M.F., additional, Farkas, N., additional, Zádori, N., additional, Szakó, L., additional, Szentesi, A., additional, Eröss, B.M., additional, Miklós, E., additional, Zemplényi, A., additional, Birkás, B., additional, Csathó, Á., additional, Hartung, I., additional, Nagy, T., additional, Czakó, L., additional, Izbéki, F., additional, Gajdán, L., additional, Illés, D., additional, Marino, M.V., additional, Papp, M., additional, Miarbella, A., additional, Malecka-Panas, E., additional, Zatorski, H., additional, Ruiz-Rebollo, M.-L., additional, Capurso, G., additional, Gheroghe, C., additional, Saizu, I.A., additional, Párniczky, A., additional, and Hegyi, P., additional

Published
2021
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27. Recurrent acute pancreatitis prevention by the elimination of alcohol and cigarette smoking (reappear): Protocol of a randmozied controlled trial and a cohort study

Author

K. Ocskay, M.F. Juhász, N. Farkas, N. Zádori, L. Szakó, A. Szentesi, B.M. Eröss, E. Miklós, A. Zemplényi, B. Birkás, Á. Csathó, I. Hartung, T. Nagy, L. Czakó, F. Izbéki, L. Gajdán, D. Illés, M.V. Marino, M. Papp, A. Miarbella, E. Malecka-Panas, H. Zatorski, M.-L. Ruiz-Rebollo, G. Capurso, C. Gheroghe, I.A. Saizu, A. Párniczky, and P. Hegyi

Subjects
Hepatology, Endocrinology, Diabetes and Metabolism, Gastroenterology
Published
2021

29. The use of Early Achievable SeveritY (EASY) index is beneficial for rapid risk stratification in acute pancreatitis at hospital admission

Author

P. Aldis, Gabriella Pár, O. Imanta, Balázs Németh, Mária Papp, E. Stilidi, Zsolt Szakács, A. Tüzün Ince, Szilárd Gódi, F. Eszter, Balázs Kui, S. Ertan, Adrienn Halász, Kristina Zadorozhna, M. Artautas, Patai î, S. Ville, G. László, Miklós Ihász, P. Goran, Andrea Szentesi, Laszlo Lakatos, P. Giulia, Hunor Farkas, Nelli Farkas, Ferenc Izbéki, Shamil Galeev, Péter Hegyi, József Czimmer, M. Elena Ramirez, M. Jinga, Imola Török, Judit Bajor, B. Eross, P. Petr, V. Shelat, H. Masayasu, Dóra Illés, I. Kovalskaya, M. Melania, Patrícia Sarlós, Katalin Márta, L. Andrey, G. Robu, C. Gabriele, Vincze î, István Hritz, and Noémi Gede

Subjects
medicine.medical_specialty, Index (economics), Hepatology, business.industry, Endocrinology, Diabetes and Metabolism, Emergency medicine, Hospital admission, Risk stratification, Gastroenterology, Medicine, Acute pancreatitis, business, medicine.disease
Published
2020

32. Predictive biomarkers of pancreatic necrosis in acute pancreatitis

Author

Szabolcs Kiss, Mária Földi, Ferenc Izbéki, Adrienn Halász, Márta Varga, Áron Vincze, Szilárd Gódi, Judit Bajor, Roland Hágendorn, József Czimmer, Péter Mátrai, József Hamvas, Péter Varjú, Stefan Crai, Artautas Mickevicius, Árpád Patai, Miklós Ihász, Tamás Takács, Andrea Szentesi, Andrea Párniczky, and Péter Hegyi

Subjects
Hepatology, Endocrinology, Diabetes and Metabolism, Gastroenterology
Published
2019

33. The use of Early Achievable SeveritY (EASY) index is beneficial for rapid risk stratification in acute pancreatitis on hospital admission

Author

Balázs Kui, Szilárd Gódi, Judit Bajor, Imola Török, Melania Macaria, Hunor Farkas, Artautas Mickevicius, Ville Sallinen, Elena Ramirez Maldonado, Mária Papp, György Kovács, Eszter Fehér, Patrícia Sarlós, Shamil Galeev, Balázs Németh, Áron Vincze, Petr Pencik, Imanta Ozola-Zalite, Aldis Pukitis, Andrey Litvin, Inna Kovalskaya, József Czimmer, Gabriella Pár, István Hritz, Dóra Illés, Andrea Szentesi, László Lakatos, Gabriele Capurso, Árpád Patai, Elena Stilidi, Giulia Peserico, Kristina Zadorozhna, Ertan Sonmez, Ali Tüzün Ince, Shelat Vishalkumar, Masayasu Horibe, Miklós Ihász, Bálint Mihály Erőss, Katalin Márta, Zsolt Szakács, Nelli Farkas, Noémi Gede, Adrienn Halász, László Gajdán, Ferenc Izbéki, Goran Poropat, Mariana Jinga, Georgiana Robu, and Péter Hegyi

Subjects
Hepatology, Endocrinology, Diabetes and Metabolism, Gastroenterology
Published
2019

34. Investigating the early phase of chronic pancreatitis: the Goulash-Plus trial protocol and the results of the first 10 months

Author

Kató, Dorottya, primary, Mikó, Alexandra, additional, Lillik, Veronika, additional, Erőss, Bálint, additional, Sarlós, Patrícia, additional, Hegyi, Péter, additional, Pécsi, Dániel, additional, Márta, Kata, additional, Vincze, Aron, additional, Bódis, Beáta, additional, Nemes, Orsolya, additional, Faluhelyi, Nándor, additional, Farkas, Orsolya, additional, Szentesi, Andrea, additional, Sahin-Tóth, Miklós, additional, Lerch, Markus M., additional, Neoptolemos, John P., additional, and Petersen, Ole H., additional

Published
2019
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35. LIFEStyle, prevention and risk of acute PANcreatitis (LIFESPAN): Protocol of a prospective, multicentre and multinational observational case-control study

Author

Darvasi, Erika, primary, Koncz, Balázs, additional, Erdösi, Dalma, additional, Szentesi, Andrea, additional, Márta, Katalin, additional, Erőss, Bálint, additional, Pécsi, Dániel, additional, Gyöngyi, Zoltán, additional, Girán, János, additional, Farkas, Nelli, additional, Papp, Mária, additional, Fehér, Eszter, additional, Vitális, Zsuzsanna, additional, Janka, Tamás, additional, Vincze, Áron, additional, Izbéki, Ferenc, additional, Dunás-Varga, Veronika, additional, Gajdán, László, additional, Török, Imola, additional, Antal, Judit, additional, Zádori, Noémi, additional, Lerch, Markus M., additional, Neoptolemos, John P., additional, Sahin-Tóth, Miklós, additional, Petersen, Ole H., additional, and Hegyi, Péter, additional

Published
2019
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37. The use of Early Achievable SeveritY (EASY) index is beneficial for rapid risk stratification in acute pancreatitis on hospital admission

Author

Kui, Balázs, primary, Gódi, Szilárd, additional, Bajor, Judit, additional, Török, Imola, additional, Macaria, Melania, additional, Farkas, Hunor, additional, Mickevicius, Artautas, additional, Sallinen, Ville, additional, Maldonado, Elena Ramirez, additional, Papp, Mária, additional, Kovács, György, additional, Fehér, Eszter, additional, Sarlós, Patrícia, additional, Galeev, Shamil, additional, Németh, Balázs, additional, Vincze, Áron, additional, Pencik, Petr, additional, Ozola-Zalite, Imanta, additional, Pukitis, Aldis, additional, Litvin, Andrey, additional, Kovalskaya, Inna, additional, Czimmer, József, additional, Pár, Gabriella, additional, Hritz, István, additional, Illés, Dóra, additional, Szentesi, Andrea, additional, Lakatos, László, additional, Capurso, Gabriele, additional, Patai, Árpád, additional, Stilidi, Elena, additional, Peserico, Giulia, additional, Zadorozhna, Kristina, additional, Sonmez, Ertan, additional, Ince, Ali Tüzün, additional, Vishalkumar, Shelat, additional, Horibe, Masayasu, additional, Ihász, Miklós, additional, Erőss, Bálint Mihály, additional, Márta, Katalin, additional, Szakács, Zsolt, additional, Farkas, Nelli, additional, Gede, Noémi, additional, Halász, Adrienn, additional, Gajdán, László, additional, Izbéki, Ferenc, additional, Poropat, Goran, additional, Jinga, Mariana, additional, Robu, Georgiana, additional, and Hegyi, Péter, additional

Published
2019
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38. Outcomes and timing of endoscopic retrograde cholangiopancreatography for acute biliary pancreatitis

Author

Halász, Adrienn, primary, Pécsi, Dániel, additional, Farkas, Nelli, additional, Izbéki, Ferenc, additional, Gajdán, László, additional, Fejes, Roland, additional, Hamvas, József, additional, Takács, Tamás, additional, Szepes, Zoltán, additional, Czakó, László, additional, Vincze, Aron, additional, Gódi, Szilárd, additional, Szentesi, Andrea, additional, Párniczky, Andrea, additional, Illés, Dóra, additional, Kui, Balázs, additional, Varjú, Péter, additional, Márta, Kata, additional, Varga, Márta, additional, Novák, János, additional, Szepes, Attila, additional, Bod, Barnabás, additional, Ihász, Miklós, additional, Hegyi, Péter, additional, Hritz, Istvan, additional, and Erőss, Bálint, additional

Published
2019
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39. Predictive biomarkers of pancreatic necrosis in acute pancreatitis

Author

Kiss, Szabolcs, primary, Földi, Mária, additional, Izbéki, Ferenc, additional, Halász, Adrienn, additional, Varga, Márta, additional, Vincze, Áron, additional, Gódi, Szilárd, additional, Bajor, Judit, additional, Hágendorn, Roland, additional, Czimmer, József, additional, Mátrai, Péter, additional, Hamvas, József, additional, Varjú, Péter, additional, Crai, Stefan, additional, Mickevicius, Artautas, additional, Patai, Árpád, additional, Ihász, Miklós, additional, Takács, Tamás, additional, Szentesi, Andrea, additional, Párniczky, Andrea, additional, and Hegyi, Péter, additional

Published
2019
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40. Role of common CASR variants in chronic pancreatitis

Author

Takáts, Amanda, primary, Berke, Gergő, additional, Szentesi, Andrea, additional, Farkas, Gyula, additional, Izbéki, Ferenc, additional, Erőss, Bálint, additional, Czakó, László, additional, Vincze, Áron, additional, Hegyi, Péter, additional, Sahin-Tóth, Miklós, additional, and Hegyi, Eszter, additional

Published
2019
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41. Assessing the clinical significance of PRSS1 intronic variants

Author

Hegyi, Eszter, primary, Tóth, Anna Zsófia, additional, Szentesi, Andrea, additional, Farkas, Gyula, additional, Izbéki, Ferenc, additional, Erőss, Bálint, additional, Czakó, László, additional, Vincze, Áron, additional, Hegyi, Péter, additional, and Sahin-Tóth, Miklós, additional

Published
2019
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42. Mutations in the 5’ upstream region of Chymotrypsinogen C gene are not associated with chronic pancreatitis

Author

Németh, Balázs, primary, Madarász, Réka, additional, Nagy, Adrienn, additional, Sándor, Máté, additional, Takács, Tamás, additional, Farkas, Gyula, additional, Izbéki, Ferenc, additional, Czakó, László, additional, Szmola, Richárd, additional, Gervain, Judit, additional, Gódi, Szilárd, additional, Szentesi, Andrea, additional, Szücs, Ákos, additional, Sahin-Tóth, Miklós, additional, and Hegyi, Péter, additional

Published
2019
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44. Genetic analysis of the bicarbonate secreting anion exchanger SLC26A6 in chronic pancreatitis

Author

Andrea Párniczky, Miklós Sahin-Tóth, Csilla Andorka, Anita Illés, Gábor Veres, János Novák, Natália Lásztity, Judit Gervain, Zsolt Dubravcsik, József Maléth, Tamás Takács, Zsolt Szentkereszty, Attila Szepes, Balázs Németh, Richárd Szmola, Zoltán Rakonczay, Gyula Farkas, Anita Balázs, Zoltán Szepes, Eszter Hegyi, Áron Vincze, Stefan Crai, Dezső Kelemen, Jonas Rosendahl, József Hamvas, Claudia Ruffert, Zsolt Molnár, Márta Varga, Péter Hegyi, László Czakó, Adrienn Halász, István Hritz, János Sümegi, Ferenc Izbéki, and Barnabás Bod

Subjects
Adult, Genetic Markers, Male, Linkage disequilibrium, Pancreatic disease, Endocrinology, Diabetes and Metabolism, Exon, Pancreatitis, Chronic, medicine, Humans, Coding region, Missense mutation, Genetic Predisposition to Disease, Aged, Aged, 80 and over, Genetics, Hepatology, biology, Haplotype, Gastroenterology, Membrane Transport Proteins, Sequence Analysis, DNA, Middle Aged, medicine.disease, Cystic fibrosis transmembrane conductance regulator, Haplotypes, Sulfate Transporters, Case-Control Studies, Mutation, biology.protein, Female, Restriction fragment length polymorphism, Polymorphism, Restriction Fragment Length
Abstract

Background Pancreatic ductal HCO 3 - secretion is critically dependent on the cystic fibrosis transmembrane conductance regulator chloride channel (CFTR) and the solute-linked carrier 26 member 6 anion transporter (SLC26A6). Deterioration of HCO 3 - secretion is observed in chronic pancreatitis (CP), and CFTR mutations increase CP risk. Therefore, SLC26A6 is a reasonable candidate for a CP susceptibility gene, which has not been investigated in CP patients so far. Methods As a first screening cohort, 106 subjects with CP and 99 control subjects with no pancreatic disease were recruited from the Hungarian National Pancreas Registry. In 60 non-alcoholic CP cases the entire SLC26A6 coding region was sequenced. In the Hungarian cohort variants c.616G > A (p.V206M) and c.1191C > A (p.P397=) were further genotyped by restriction fragment length polymorphism analysis. In a German replication cohort all exons were sequenced in 40 non-alcoholic CP cases and variant c.616G > A (p.V206M) was further analyzed by sequencing in 321 CP cases and 171 controls. Results Sequencing of the entire coding region revealed four common variants: intronic variants c.23 + 78_110del, c.183-4C > A, c.1134 + 32C > A, and missense variant c.616G > A (p.V206M) which were found in linkage disequilibrium indicating a conserved haplotype. The distribution of the haplotype did not show a significant difference between patients and controls in the two cohorts. A synonymous variant c.1191C > A (p.P397=) and two intronic variants c.1248 + 9_20del and c.-10C > T were detected in single cases. Conclusion Our data show that SLC26A6 variants do not alter the risk for the development of CP.

Published
2015

47. Predictive biomarkers of pancreatic necrosis in acute pancreatitis

Author

Andrea Párniczky, Judit Bajor, Artautas Mickevicius, Péter Varjú, Áron Vincze, Ferenc Izbéki, Adrienn Halász, Stefan Crai, Miklós Ihász, Gódi Szilárd, József Hamvas, Árpád V. Patai, Péter Hegyi, Péter Mátrai, Szabolcs Kiss, Tamás Takács, Andrea Szentesi, József Czimmer, Márta Varga, and Roland Hágendorn

Subjects
medicine.medical_specialty, Necrosis, Hepatology, business.industry, Endocrinology, Diabetes and Metabolism, Gastroenterology, medicine.disease, Internal medicine, Medicine, Acute pancreatitis, medicine.symptom, business, Predictive biomarker
Published
2018

48. Role of common CASR variants in chronic pancreatitis

Author

Amanda Takáts, Gergő Berke, Andrea Szentesi, Gyula Farkas, Ferenc Izbéki, Bálint Erőss, László Czakó, Áron Vincze, Péter Hegyi, Miklós Sahin-Tóth, and Eszter Hegyi

Subjects
Hepatology, Endocrinology, Diabetes and Metabolism, Gastroenterology
Published
2019

49. Investigating the early phase of chronic pancreatitis: the Goulash-Plus trial protocol and the results of the first 10 months

Author

Dorottya Kató, Alexandra Mikó, Veronika Lillik, Bálint Erőss, Patrícia Sarlós, Péter Hegyi, Dániel Pécsi, Kata Márta, Aron Vincze, Beáta Bódis, Orsolya Nemes, Nándor Faluhelyi, Orsolya Farkas, Andrea Szentesi, Miklós Sahin-Tóth, Markus M. Lerch, John P. Neoptolemos, and Ole H. Petersen

Subjects
Hepatology, Endocrinology, Diabetes and Metabolism, Gastroenterology
Published
2019

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