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2. Classification of PRSS1 variants responsible for chronic pancreatitis: An expert perspective from the Franco-Chinese GREPAN Study Group

Author

Abrantes, Amandine, Aguilera Munoz, Lina, Albouys, Jérémie, Alric, Laurent, Amiot, Xavier, Archambeaud, Isabelle, Audiau, Solène, Bastide, Laetitia, Baudon, Julien, Bellaiche, Guy, Bellon, Serge, Bertrand, Valérie, Bideau, Karine, Billiemaz, Kareen, Billioud, Claire, Bonnefoy, Sabine, Borderon, Corinne, Bournet, Barbara, Breton, Estelle, Brugel, Mathias, Buscail, Louis, Cadiot, Guillaume, Camus, Marine, Causse, Xavier, Chamouard, Patrick, Chaput, Ulriikka, Cholet, Franck, Ciocan, Dragos Marius, Clavel, Christine, Coffin, Benoit, Coimet-Berger, Laura, Creveaux, Isabelle, Culetto, Adrian, Daboussi, Oussama, De Mestier, Louis, Degand, Thibault, D'Engremont, Christelle, Denis, Bernard, Dermine, Solène, Desgrippes, Romain, Drouet D'Aubigny, Augustin, Enaud, Raphaël, Fabre, Alexandre, Gargot, Dany, Gelsi, Eve, Gentilcore, Elena, Gincul, Rodica, Ginglinger-Favre, Emmanuelle, Giovannini, Marc, Gomercic, Cécile, Gondran, Hannah, Grainville, Thomas, Grandval, Philippe, Grasset, Denis, Grimaldi, Stéphane, Grimbert, Sylvie, Hagege, Hervé, Heissat, Sophie, Hentic, Olivia, Herber-Mayne, Anne, Hervouet, Marc, Hoibian, Solene, Jacques, Jérémie, Jais, Bénédicte, Kaassis, Mehdi, Koch, Stéphane, Lacaze, Elodie, Lacroute, Joël, Lamireau, Thierry, Laurent, Lucie, Le Guillou, Xavier, Le Rhun, Marc, Leblanc, Sarah, Levy, Philippe, Lievre, Astrid, Lorenzo, Diane, Maire, Frédérique, Marcel, Kévin, Matias, Clément, Mauillon, Jacques, Morgant, Stéphanie, Moussata, Driffa, Muller, Nelly, Nambot, Sophie, Napoleon, Bertrand, Olivier, Anne, Pagenault, Maël, Pelletier, Anne-laure, Pennec, Olivier, Pinard, Fabien, Pioche, Mathieu, Prost, Bénédicte, Queneherve, Lucille, Rebours, Vinciane, Reboux, Noemi, Rekik, Samia, Riachi, Ghassan, Rohmer, Barbara, Roquelaure, Bertrand, Rosa Hezode, Isabelle, Rostain, Florian, Saurin, Jean-Christophe, Servais, Laure, Stan-Iuga, Roxana, Subtil, Clément, Texier, Charles, Thomassin, Lucie, Tougeron, David, Tsakiris, Laurent, Valats, Jean-Christophe, Vuitton, Lucine, Wallenhorst, Timothée, Wangerme, Marc, Zanaldi, Hélène, Zerbib, Frank, Bai, Chen-Guang, Bian, Yun, Cai, Zhen-Zhai, Chang, Xiao-Yan, Chen, Guo-Dong, Cheng, Li, Chen, Yu, Guo, Jin-Tao, Guo, Tao, Han, Jun-Ling, He, Chao-Hui, Hu, Liang-Hao, Huang, Hao-Jie, Huang, Li, Huang, Li-Ya, Huang, Si-Lin, Huang, Wei, Jiang, Fei, Jiang, Hui, Lu, Feng-Chun, Lu, Guo-Tao, Lu, Zi-Peng, Li, Hui-Ping, Li, Jing, Li, Le, Li, Qiang, Li, Xiao-Yu, Lin, Qing, Lin, Yu-Li, Liu, Gai-Fang, Liu, Jie-Min, Liu, Li-Xin, Liu, Pi, Liu, Yi-Pin, Lu, Dong, Shao, Xiao-Dong, Shao, Zhuo, Song, Xu-Rui, Wang, Lei, Wang, Li-Juan, Wang, Li-Sheng, Wang, Lin, Wang, Wei, Wang, Zheng, Wen, Li, Wu, Xi, Xin, Lei, Xue, Jing, Yang, Hong, Yang, Jian-Feng, Yin, Tao, Zhang, Bei-Ping, Zhang, Guo-Wei, Zhang, Hong, Zhang, Rong-Chun, Zhao, Yi-Jun, Zhou, Si-Si, Zhu, Ke-Xiang, Masson, Emmanuelle, Zou, Wen-Bin, Pu, Na, Génin, Emmanuelle, Wu, Hao, Lin, Jin-Huan, Wang, Yuan-Chen, Li, Zhao-Shen, Cooper, David N., Férec, Claude, Liao, Zhuan, and Chen, Jian-Min

Published
2023
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3. Diagnosis and treatment of exocrine pancreatic insufficiency in chronic pancreatitis: An international expert survey and case vignette study

Author

Falconi, Massimo, Zou, Wen-Bin, Engjom, Trond, Ooi, Chee Y., Sutton, Robert, Frulloni, Luca, Neoptolemos, John, Wilcox, Charles, Miroslav, Vujasinovic, Trikudanathan, Guru, Liao, Zhuan, Hauge, Truls, Mössner, Joachim, Hoge, Chantal, Fockens, Paul, Mieog, Sven, Capurso, Gabriele, Cui, Yunfeng, de Madaria, Enrique, Distler, Marius, Aghdassi, Ali, Whitcomb, David C., Russell, Kylie, Beyer, Georg, Kunovsky, Lumír, Kwanten, Wilhelmus, Nava, Andrea Kazemi, Conlon, Kevin, Siriwardena, A.K., Paiella, Salvatore, Alconchel, Felipe, Marino, Marco Vito, de Meijer, Vincent E., Domingo, Carlos, Kleeff, Jorg, Lakshmanan, Aarti, Lie Chu, Michael Jen, Bouwense, Stefan, Nashidengo, Pueya Rashid, Konstantinos, Perivoliotis, Muttillo, Edoardo Maria, Umar, Garzali Ibrahim, Castro Santiago, Maria Jesus, Lopez-Lopez, Victor, Torri, Francesco, Schmelzle, Moritz, Ignatavicius, Povilas, Wicherts, Dennis, Gomes, Antonio, Machairas, Nikolaos A., Dorovinis, Panagiotis I., Serrablo, Alejandro, Soreide, Kjetil, Rahbari, Mohammad, Jie Chu, Michael Jen, Ptasnuka, Margarita, Petrulionis, Marius, Noel, Colin Byron, Castro, Ernest, Di Martino, Marcello, Recordare, Alfonso, Stättner, Stefan, Ausania, Fabio, Hartman, Vera, Roeyen, Geert, Egorov, Viacheslav, Vanagas, Tomas, Ebrahim, Mohamed, Arabadzhieva, Elena, Malleo, Giuseppe, Li, Liang, Adams, David, Oracz, Grzegorz, Nageshwar, Reddy D., Waldthaler, Alexander, Masamune, Atsushi, Drewes, Asbjorn Mohr, Amodio, Antonio, Tirkes, Temel, Srivastava, Anshu, Beilman, Gregory J., Berger, Zoltan, Lindkvist, Bjorn, Cavestro, Giulia Martina, Gariepy, Cheryl, Czakó, Laszlo, Di Leo, Milena, Sharma, Vishal, Lakhtakia, Sundeep, Rana, Surinder Singh, Duggan, Sinaed N., Kwon, Chang-Il, Phillips, Anna Evans, Forsmark, Christopher E., Gleeson, Ferga C., Lehman, Glen A., Greenhalf, William, Costamagna, Guido, Halloran, Christopher M., Friess, Helmut, Rasmussen, Henrik Hojgaard, Ikeura, Tsukasa, Haldorsen, Ingfrid S., Itoi, Takao, Izbicki, Jacob R., Windsor, John, Poulsen, Jakob Lykke, Frokjaer, Jens Brondum, Larino-Noia, Jose, Wang, Dan, Garcia, Julio Iglesias, Kalaitzakis, Evangelos, Wertheim-Tysarowska, Kararzyna, Kubota, Kensuke, Larusch, Jessica, Lerch, Markus M., Hu, Liang-Hao, Erkan, Mert, Machicado, Jorg D., Arvanitakis, Marianna, Buchler, Markus W., Levy, Marlon F., Heyman, Melvin B., Nojgaard, Camilla, Khashab, Mouen A., Delhaye, Myriam, Ogura, Takeshi, Okazaki, Kazuichi, Ghaneh, Paula, Banks, Peter A., Gupta, Pankaj, Papachristou, Georgios I., Michl, Patrick, Levy, Philippe, Pukitis, Aldis, Pezzilli, Raffaele, Baron, Ryan D., Amann, Stephen T., Schwarzenberg, Sarah Jane, Isaji, Shuiji, Olesen, Soren Schou, Novovic, Srdan, Hughes, Steven J., Werlin, Steven L., Gonska, Tanja, Gardner, Timothy B., Topazian, Mark D., Weiss, Frank Ulrich, Akshintala, Venakata S., Morinville, Veronique D., Rebours, Vinciane, Vincze, Aron, Singh, Vikesh K., Cui, Naiqiang, Zhang, Hong, Li, Zhao-shen, de Rijk, Florence E.M., van Veldhuisen, Charlotte L., Besselink, Marc G., van Hooft, Jeanin E., van Santvoort, Hjalmar C., van Geenen, Erwin J.M., Hegyi, Peter, Löhr, J-Matthias, Dominguez-Munoz, Juan E., de Jonge, Pieter Jan F., Bruno, Marco J., and Verdonk, Robert C.

Published
2022
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6. Classification of PRSS1 variants responsible for chronic pancreatitis: An expert perspective from the Franco-Chinese GREPAN Study Group

Author

Masson, Emmanuelle, primary, Zou, Wen-Bin, additional, Pu, Na, additional, Rebours, Vinciane, additional, Génin, Emmanuelle, additional, Wu, Hao, additional, Lin, Jin-Huan, additional, Wang, Yuan-Chen, additional, Li, Zhao-Shen, additional, Cooper, David N., additional, Férec, Claude, additional, Liao, Zhuan, additional, Chen, Jian-Min, additional, Abrantes, Amandine, additional, Aguilera Munoz, Lina, additional, Albouys, Jérémie, additional, Alric, Laurent, additional, Amiot, Xavier, additional, Archambeaud, Isabelle, additional, Audiau, Solène, additional, Bastide, Laetitia, additional, Baudon, Julien, additional, Bellaiche, Guy, additional, Bellon, Serge, additional, Bertrand, Valérie, additional, Bideau, Karine, additional, Billiemaz, Kareen, additional, Billioud, Claire, additional, Bonnefoy, Sabine, additional, Borderon, Corinne, additional, Bournet, Barbara, additional, Breton, Estelle, additional, Brugel, Mathias, additional, Buscail, Louis, additional, Cadiot, Guillaume, additional, Camus, Marine, additional, Causse, Xavier, additional, Chamouard, Patrick, additional, Chaput, Ulriikka, additional, Cholet, Franck, additional, Ciocan, Dragos Marius, additional, Clavel, Christine, additional, Coffin, Benoit, additional, Coimet-Berger, Laura, additional, Creveaux, Isabelle, additional, Culetto, Adrian, additional, Daboussi, Oussama, additional, De Mestier, Louis, additional, Degand, Thibault, additional, D'Engremont, Christelle, additional, Denis, Bernard, additional, Dermine, Solène, additional, Desgrippes, Romain, additional, Drouet D'Aubigny, Augustin, additional, Enaud, Raphaël, additional, Fabre, Alexandre, additional, Gargot, Dany, additional, Gelsi, Eve, additional, Gentilcore, Elena, additional, Gincul, Rodica, additional, Ginglinger-Favre, Emmanuelle, additional, Giovannini, Marc, additional, Gomercic, Cécile, additional, Gondran, Hannah, additional, Grainville, Thomas, additional, Grandval, Philippe, additional, Grasset, Denis, additional, Grimaldi, Stéphane, additional, Grimbert, Sylvie, additional, Hagege, Hervé, additional, Heissat, Sophie, additional, Hentic, Olivia, additional, Herber-Mayne, Anne, additional, Hervouet, Marc, additional, Hoibian, Solene, additional, Jacques, Jérémie, additional, Jais, Bénédicte, additional, Kaassis, Mehdi, additional, Koch, Stéphane, additional, Lacaze, Elodie, additional, Lacroute, Joël, additional, Lamireau, Thierry, additional, Laurent, Lucie, additional, Le Guillou, Xavier, additional, Le Rhun, Marc, additional, Leblanc, Sarah, additional, Levy, Philippe, additional, Lievre, Astrid, additional, Lorenzo, Diane, additional, Maire, Frédérique, additional, Marcel, Kévin, additional, Matias, Clément, additional, Mauillon, Jacques, additional, Morgant, Stéphanie, additional, Moussata, Driffa, additional, Muller, Nelly, additional, Nambot, Sophie, additional, Napoleon, Bertrand, additional, Olivier, Anne, additional, Pagenault, Maël, additional, Pelletier, Anne-laure, additional, Pennec, Olivier, additional, Pinard, Fabien, additional, Pioche, Mathieu, additional, Prost, Bénédicte, additional, Queneherve, Lucille, additional, Reboux, Noemi, additional, Rekik, Samia, additional, Riachi, Ghassan, additional, Rohmer, Barbara, additional, Roquelaure, Bertrand, additional, Rosa Hezode, Isabelle, additional, Rostain, Florian, additional, Saurin, Jean-Christophe, additional, Servais, Laure, additional, Stan-Iuga, Roxana, additional, Subtil, Clément, additional, Texier, Charles, additional, Thomassin, Lucie, additional, Tougeron, David, additional, Tsakiris, Laurent, additional, Valats, Jean-Christophe, additional, Vuitton, Lucine, additional, Wallenhorst, Timothée, additional, Wangerme, Marc, additional, Zanaldi, Hélène, additional, Zerbib, Frank, additional, Bai, Chen-Guang, additional, Bian, Yun, additional, Cai, Zhen-Zhai, additional, Chang, Xiao-Yan, additional, Chen, Guo-Dong, additional, Cheng, Li, additional, Chen, Yu, additional, Guo, Jin-Tao, additional, Guo, Tao, additional, Han, Jun-Ling, additional, He, Chao-Hui, additional, Hu, Liang-Hao, additional, Huang, Hao-Jie, additional, Huang, Li, additional, Huang, Li-Ya, additional, Huang, Si-Lin, additional, Huang, Wei, additional, Jiang, Fei, additional, Jiang, Hui, additional, Lu, Feng-Chun, additional, Lu, Guo-Tao, additional, Lu, Zi-Peng, additional, Li, Hui-Ping, additional, Li, Jing, additional, Li, Le, additional, Li, Qiang, additional, Li, Xiao-Yu, additional, Lin, Qing, additional, Lin, Yu-Li, additional, Liu, Gai-Fang, additional, Liu, Jie-Min, additional, Liu, Li-Xin, additional, Liu, Pi, additional, Liu, Yi-Pin, additional, Lu, Dong, additional, Shao, Xiao-Dong, additional, Shao, Zhuo, additional, Song, Xu-Rui, additional, Wang, Lei, additional, Wang, Li-Juan, additional, Wang, Li-Sheng, additional, Wang, Lin, additional, Wang, Wei, additional, Wang, Zheng, additional, Wen, Li, additional, Wu, Xi, additional, Xin, Lei, additional, Xue, Jing, additional, Yang, Hong, additional, Yang, Jian-Feng, additional, Yin, Tao, additional, Zhang, Bei-Ping, additional, Zhang, Guo-Wei, additional, Zhang, Hong, additional, Zhang, Rong-Chun, additional, Zhao, Yi-Jun, additional, Zhou, Si-Si, additional, and Zhu, Ke-Xiang, additional

Published
2023
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7. Diagnosis and treatment of exocrine pancreatic insufficiency in chronic pancreatitis: An international expert survey and case vignette study

Author

Florence E.M. de Rijk, Charlotte L. van Veldhuisen, Marc G. Besselink, Jeanin E. van Hooft, Hjalmar C. van Santvoort, Erwin J.M. van Geenen, Peter Hegyi, J-Matthias Löhr, Juan E. Dominguez-Munoz, Pieter Jan F. de Jonge, Marco J. Bruno, Robert C. Verdonk, Massimo Falconi, Wen-Bin Zou, Trond Engjom, Chee Y. Ooi, Robert Sutton, Luca Frulloni, John Neoptolemos, Charles Wilcox, Vujasinovic Miroslav, Guru Trikudanathan, Zhuan Liao, Truls Hauge, Joachim Mössner, Chantal Hoge, Paul Fockens, Sven Mieog, Gabriele Capurso, Yunfeng Cui, Enrique de Madaria, Marius Distler, Ali Aghdassi, David C. Whitcomb, Kylie Russell, Georg Beyer, Lumír Kunovsky, Wilhelmus Kwanten, Andrea Kazemi Nava, Kevin Conlon, A.K. Siriwardena, Salvatore Paiella, Felipe Alconchel, Marco Vito Marino, Vincent E. de Meijer, Carlos Domingo, Jorg Kleeff, Aarti Lakshmanan, Michael Jen Lie Chu, Stefan Bouwense, Pueya Rashid Nashidengo, Perivoliotis Konstantinos, Edoardo Maria Muttillo, Garzali Ibrahim Umar, Maria Jesus Castro Santiago, Victor Lopez-Lopez, Francesco Torri, Moritz Schmelzle, Povilas Ignatavicius, Dennis Wicherts, Antonio Gomes, Nikolaos A. Machairas, Panagiotis I. Dorovinis, Alejandro Serrablo, Kjetil Soreide, Mohammad Rahbari, Michael Jen Jie Chu, Margarita Ptasnuka, Marius Petrulionis, Colin Byron Noel, Ernest Castro, Marcello Di Martino, Alfonso Recordare, Stefan Stättner, Fabio Ausania, Vera Hartman, Geert Roeyen, Viacheslav Egorov, Tomas Vanagas, Mohamed Ebrahim, Elena Arabadzhieva, Giuseppe Malleo, Liang Li, David Adams, Grzegorz Oracz, Reddy D. Nageshwar, Alexander Waldthaler, Atsushi Masamune, Asbjorn Mohr Drewes, Antonio Amodio, Temel Tirkes, Anshu Srivastava, Gregory J. Beilman, Zoltan Berger, Bjorn Lindkvist, Giulia Martina Cavestro, Cheryl Gariepy, Laszlo Czakó, Milena Di Leo, Vishal Sharma, Sundeep Lakhtakia, Surinder Singh Rana, Sinaed N. Duggan, Chang-Il Kwon, Anna Evans Phillips, Christopher E. Forsmark, Ferga C. Gleeson, Glen A. Lehman, William Greenhalf, Guido Costamagna, Christopher M. Halloran, Helmut Friess, Henrik Hojgaard Rasmussen, Tsukasa Ikeura, Ingfrid S. Haldorsen, Takao Itoi, Jacob R. Izbicki, John Windsor, Jakob Lykke Poulsen, Jens Brondum Frokjaer, Jose Larino-Noia, Dan Wang, Julio Iglesias Garcia, Evangelos Kalaitzakis, Kararzyna Wertheim-Tysarowska, Kensuke Kubota, Jessica Larusch, Markus M. Lerch, Liang-Hao Hu, Mert Erkan, Jorg D. Machicado, Marianna Arvanitakis, Markus W. Buchler, Marlon F. Levy, Melvin B. Heyman, Camilla Nojgaard, Mouen A. Khashab, Myriam Delhaye, Takeshi Ogura, Kazuichi Okazaki, Paula Ghaneh, Peter A. Banks, Pankaj Gupta, Georgios I. Papachristou, Patrick Michl, Philippe Levy, Aldis Pukitis, Raffaele Pezzilli, Ryan D. Baron, Stephen T. Amann, Sarah Jane Schwarzenberg, Shuiji Isaji, Soren Schou Olesen, Srdan Novovic, Steven J. Hughes, Steven L. Werlin, Tanja Gonska, Timothy B. Gardner, Mark D. Topazian, Frank Ulrich Weiss, Venakata S. Akshintala, Veronique D. Morinville, Vinciane Rebours, Aron Vincze, Vikesh K. Singh, Naiqiang Cui, Hong Zhang, Zhao-shen Li, Integrated Research on Energy, Environment & Socie, Molecular Active Systems, Gastroenterology and hepatology, Gastroenterology & Hepatology, Graduate School, Surgery, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and Gastroenterology and Hepatology

Subjects
Pancreatic enzyme replacement therapy, Hepatology, Endocrinology, Diabetes and Metabolism, Clinical Decision-Making, Exocrine pancreatic insufficiency, Gastroenterology, Other Research Radboud Institute for Molecular Life Sciences [Radboudumc 0], Steatorrhea, SDG 3 - Good Health and Well-being, Expert opinion, Pancreatitis, Chronic, Humans, HaPanEU-guidelines, Pancreas, Chronic pancreatitis
Abstract

IntroductionDespite evidence-based guidelines, exocrine pancreatic insufficiency is frequently underdiagnosed and undertreated in patients with chronic pancreatitis. Therefore, the aim of this study is to provide insight into the current opinion and clinical decision-making of international pancreatologists regarding the management of exocrine pancreatic insufficiency.MethodsAn online survey and case vignette study was sent to experts in chronic pancreatitis and members of various pancreatic associations: EPC, E-AHPBA and DPSG. Experts were selected based on publication record from the past 5 years.ResultsOverall, 252 pancreatologists participated of whom 44% had ≥ 15 years of experience and 35% treated ≥ 50 patients with chronic pancreatitis per year. Screening for exocrine pancreatic insufficiency as part of the diagnostic work-up for chronic pancreatitis is performed by 69% and repeated annually by 21%. About 74% considers nutritional assessment to be part of the standard work-up. Patients are most frequently screened for deficiencies of calcium (47%), iron (42%), vitamin D (61%) and albumin (59%). In case of clinically steatorrhea, 71% prescribes enzyme supplementation. Of all pancreatologists, 40% refers more than half of their patients to a dietician. Despite existing guidelines, 97% supports the need for more specific and tailored instructions regarding the management of exocrine pancreatic insufficiency.ConclusionThis survey identified a lack of consensus and substantial practice variation among international pancreatologists regarding guidelines pertaining the management of exocrine pancreatic insufficiency. These results highlight the need for further adaptation of these guidelines according to current expert opinion and the level of available scientific evidence. Introduction: Despite evidence-based guidelines, exocrine pancreatic insufficiency is frequently underdiagnosed and undertreated in patients with chronic pancreatitis. Therefore, the aim of this study is to provide insight into the current opinion and clinical decision-making of international pancreatologists regarding the management of exocrine pancreatic insufficiency. Methods: An online survey and case vignette study was sent to experts in chronic pancreatitis and members of various pancreatic associations: EPC, E-AHPBA and DPSG. Experts were selected based on publication record from the past 5 years. Results: Overall, 252 pancreatologists participated of whom 44% had ≥ 15 years of experience and 35% treated ≥ 50 patients with chronic pancreatitis per year. Screening for exocrine pancreatic insufficiency as part of the diagnostic work-up for chronic pancreatitis is performed by 69% and repeated annually by 21%. About 74% considers nutritional assessment to be part of the standard work-up. Patients are most frequently screened for deficiencies of calcium (47%), iron (42%), vitamin D (61%) and albumin (59%). In case of clinically steatorrhea, 71% prescribes enzyme supplementation. Of all pancreatologists, 40% refers more than half of their patients to a dietician. Despite existing guidelines, 97% supports the need for more specific and tailored instructions regarding the management of exocrine pancreatic insufficiency. Conclusion: This survey identified a lack of consensus and substantial practice variation among international pancreatologists regarding guidelines pertaining the management of exocrine pancreatic insufficiency. These results highlight the need for further adaptation of these guidelines according to current expert opinion and the level of available scientific evidence.

Published
2022

8. SPINK1 mutations and risk of pancreatic cancer in a Chinese cohort

Author

Nan Ru, Wen-Bin Zou, Lei Wang, Ji-Yao Guo, Xiao-Nan Xu, Jia-Hui Zhu, Zhao-Shen Li, Liang-Hao Hu, Sheng-Yong Wu, and Zhuan Liao

Subjects
China, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Protective factor, Lower risk, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Pancreatitis, Chronic, Internal medicine, Pancreatic cancer, medicine, Humans, Cumulative incidence, Genetic testing, Hepatology, medicine.diagnostic_test, business.industry, medicine.disease, Pancreatic Neoplasms, Trypsin Inhibitor, Kazal Pancreatic, 030220 oncology & carcinogenesis, Mutation, Cohort, Etiology, Pancreatitis, 030211 gastroenterology & hepatology, Carrier Proteins, business
Abstract

Objective The relationship between SPINK1 and pancreatic cancer (PC) remains controversial. The current study aimed to determine the effect of SPINK1 mutations on PC development among patients with chronic pancreatitis (CP). Methods This is a prospective observational study including a large cohort of 965 CP patients with 11-year follow-up. Patients’ demographic characteristics and clinical CP outcomes were documented in detail. Genetic testing was performed. The effect of SPINK1 mutations on the clinical development of PC was explored using Cox proportional hazards regression. Subgroup analyses conducted included the consideration of gender, onset age of CP (early- and late-onset), etiologies of CP, smoking, and alcoholic drinking status. Results PC was diagnosed in 2.5% (24/965) of patients, and the cumulative incidence rates were 0.2%, 0.8%, and 1.5% at 3, 5, and 10 years since the onset of CP, respectively. In this cohort, SPINK1 c.194+2T > C was the most common variant with a proportion of 39.1%. And the risk of PC development varied marginally between patients with and without SPINK1 mutations (Cox HR 0.39(0.14–1.04), P = 0.059). In the subgroup analyses, patients carrying SPINK1 mutations had a significantly lower risk of PC (Cox HR 0.18(0.04–0.80), P = 0.025) in the non-smoking group. SPINK1 mutations showed no significant effect in the other subgroups considered. Conclusions CP patients harboring SPINK1 mutations do not have an elevated risk of PC development compared to mutation-negative CP patients. On the contrary, SPINK1 mutations may be a protective factor in non-smoking patients with CP.

Published
2021

9. Diagnosis and treatment of exocrine pancreatic insufficiency in chronic pancreatitis: An international expert survey and case vignette study

Author

de Rijk, Florence E.M., primary, van Veldhuisen, Charlotte L., additional, Besselink, Marc G., additional, van Hooft, Jeanin E., additional, van Santvoort, Hjalmar C., additional, van Geenen, Erwin J.M., additional, Hegyi, Peter, additional, Löhr, J-Matthias, additional, Dominguez-Munoz, Juan E., additional, de Jonge, Pieter Jan F., additional, Bruno, Marco J., additional, Verdonk, Robert C., additional, Falconi, Massimo, additional, Zou, Wen-Bin, additional, Engjom, Trond, additional, Ooi, Chee Y., additional, Sutton, Robert, additional, Frulloni, Luca, additional, Neoptolemos, John, additional, Wilcox, Charles, additional, Miroslav, Vujasinovic, additional, Trikudanathan, Guru, additional, Liao, Zhuan, additional, Hauge, Truls, additional, Mössner, Joachim, additional, Hoge, Chantal, additional, Fockens, Paul, additional, Mieog, Sven, additional, Capurso, Gabriele, additional, Cui, Yunfeng, additional, de Madaria, Enrique, additional, Distler, Marius, additional, Aghdassi, Ali, additional, Whitcomb, David C., additional, Russell, Kylie, additional, Beyer, Georg, additional, Kunovsky, Lumír, additional, Kwanten, Wilhelmus, additional, Nava, Andrea Kazemi, additional, Conlon, Kevin, additional, Siriwardena, A.K., additional, Paiella, Salvatore, additional, Alconchel, Felipe, additional, Marino, Marco Vito, additional, de Meijer, Vincent E., additional, Domingo, Carlos, additional, Kleeff, Jorg, additional, Lakshmanan, Aarti, additional, Lie Chu, Michael Jen, additional, Bouwense, Stefan, additional, Nashidengo, Pueya Rashid, additional, Konstantinos, Perivoliotis, additional, Muttillo, Edoardo Maria, additional, Umar, Garzali Ibrahim, additional, Castro Santiago, Maria Jesus, additional, Lopez-Lopez, Victor, additional, Torri, Francesco, additional, Schmelzle, Moritz, additional, Ignatavicius, Povilas, additional, Wicherts, Dennis, additional, Gomes, Antonio, additional, Machairas, Nikolaos A., additional, Dorovinis, Panagiotis I., additional, Serrablo, Alejandro, additional, Soreide, Kjetil, additional, Rahbari, Mohammad, additional, Jie Chu, Michael Jen, additional, Ptasnuka, Margarita, additional, Petrulionis, Marius, additional, Noel, Colin Byron, additional, Castro, Ernest, additional, Di Martino, Marcello, additional, Recordare, Alfonso, additional, Stättner, Stefan, additional, Ausania, Fabio, additional, Hartman, Vera, additional, Roeyen, Geert, additional, Egorov, Viacheslav, additional, Vanagas, Tomas, additional, Ebrahim, Mohamed, additional, Arabadzhieva, Elena, additional, Malleo, Giuseppe, additional, Li, Liang, additional, Adams, David, additional, Oracz, Grzegorz, additional, Nageshwar, Reddy D., additional, Waldthaler, Alexander, additional, Masamune, Atsushi, additional, Drewes, Asbjorn Mohr, additional, Amodio, Antonio, additional, Tirkes, Temel, additional, Srivastava, Anshu, additional, Beilman, Gregory J., additional, Berger, Zoltan, additional, Lindkvist, Bjorn, additional, Cavestro, Giulia Martina, additional, Gariepy, Cheryl, additional, Czakó, Laszlo, additional, Di Leo, Milena, additional, Sharma, Vishal, additional, Lakhtakia, Sundeep, additional, Rana, Surinder Singh, additional, Duggan, Sinaed N., additional, Kwon, Chang-Il, additional, Phillips, Anna Evans, additional, Forsmark, Christopher E., additional, Gleeson, Ferga C., additional, Lehman, Glen A., additional, Greenhalf, William, additional, Costamagna, Guido, additional, Halloran, Christopher M., additional, Friess, Helmut, additional, Rasmussen, Henrik Hojgaard, additional, Ikeura, Tsukasa, additional, Haldorsen, Ingfrid S., additional, Itoi, Takao, additional, Izbicki, Jacob R., additional, Windsor, John, additional, Poulsen, Jakob Lykke, additional, Frokjaer, Jens Brondum, additional, Larino-Noia, Jose, additional, Wang, Dan, additional, Garcia, Julio Iglesias, additional, Kalaitzakis, Evangelos, additional, Wertheim-Tysarowska, Kararzyna, additional, Kubota, Kensuke, additional, Larusch, Jessica, additional, Lerch, Markus 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Venakata S., additional, Morinville, Veronique D., additional, Rebours, Vinciane, additional, Vincze, Aron, additional, Singh, Vikesh K., additional, Cui, Naiqiang, additional, Zhang, Hong, additional, and Li, Zhao-shen, additional

Published
2022
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17. Risk factor for diabetes mellitus in pediatric chronic pancreatitis patients

Author

Di Zhang, Zhao-Shen Li, Ya-Wei Bi, Lu Hao, Zhuan Liao, Liang-Hao Hu, and Yu Liu

Subjects
medicine.medical_specialty, Hepatology, business.industry, Endocrinology, Diabetes and Metabolism, Diabetes mellitus, Internal medicine, Gastroenterology, medicine, Pancreatitis, Risk factor, medicine.disease, business
Published
2018

24. Risk Factor for Steatorrhea in Pediatric Chronic Pancreatitis Patients

Author

Yu Liu, Liang-Hao Hu, Zhuan Liao, Teng Wang, Ya-Wei Bi, Lu Hao, and Zhao-Shen Li

Subjects
medicine.medical_specialty, Hepatology, business.industry, Endocrinology, Diabetes and Metabolism, Gastroenterology, medicine.disease, Steatorrhea, Internal medicine, medicine, Pancreatitis, medicine.symptom, Risk factor, business
Published
2018

27. ERCP development in the largest developing country: A national survey from China in 2013

Author

Lei Xin, Liang-Hao Hu, Zhuan Liao, and Zhao-Shen Li

Subjects
Economic growth, Hepatology, business.industry, Endocrinology, Diabetes and Metabolism, 010401 analytical chemistry, Gastroenterology, Developing country, 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Environmental protection, Medicine, 0210 nano-technology, China, business
Published
2016

28. Risk factors for diabetes mellitus in chronic pancreatitis: A cohort of 2,011 patients

Author

Zhao-Shen Li, Jun Pan, Liang-Hao Hu, and Lei Xin

Subjects
medicine.medical_specialty, Hepatology, business.industry, Endocrinology, Diabetes and Metabolism, Gastroenterology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, Diabetes mellitus, Cohort, medicine, Pancreatitis, 030211 gastroenterology & hepatology, business
Published
2016

29. Risk factors for steatorrhea in chronic pancreatitis: A cohort of 2153 patients

Author

Liang-Hao Hu, Bai-Rong Li, Ting Ting Du, Zhuan Liao, and Z.-S. Li

Subjects
medicine.medical_specialty, Hepatology, business.industry, Endocrinology, Diabetes and Metabolism, Gastroenterology, medicine.disease, Steatorrhea, Internal medicine, Cohort, medicine, Pancreatitis, medicine.symptom, business
Published
2016

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