1. Optimal timing of oral refeeding in mild acute pancreatitis: results of an open randomized multicenter trial.
- Author
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Teich N, Aghdassi A, Fischer J, Walz B, Caca K, Wallochny T, von Aretin A, von Boyen G, Göpel S, Ockenga J, Leodolter A, Rüddel J, Weber E, Mayerle J, Lerch MM, Mössner J, and Schiefke I
- Subjects
- Acute Disease, Adult, C-Reactive Protein analysis, Eating, Female, Humans, Length of Stay, Male, Middle Aged, Pain Measurement, Pancreatitis enzymology, Smoking, Time Factors, Lipase blood, Pancreatitis therapy
- Abstract
Objectives: The aim of this study was to compare 2 protocols regarding the initiation of oral nutrition in patients with mild acute pancreatitis., Methods: We randomized 143 patients to the Lipase directed (LIP) (n = 74) and the self selected PAT (n = 69) group. In the (PAT) group, the patients restarted eating through self-selection. In the LIP group, serum lipase had to normalize before eating., Results: The mean time between admission and oral nutrition was 2 days (interquartile range [IQR], 1-3) in the PAT group and 3 days (IQR, 2-4) in the LIP group (P < 0.005). Before and after the first meal, the mean Δ visual analogue scale (VAS) was +3.14 mm (±11.5 mm) in the PAT group and +2.85 mm (±16.4) in the LIP group (P = 0.597). The length of hospital stay was 7 days (median; IQR, 5-10.5) in the PAT group and 8 days (median; IQR, 5.75-12) in the LIP group (P = 0.315)., Conclusions: We were not able to demonstrate a difference in postprandial abdominal pain or in the length of hospital stay. Patients with self-selected eating, however, were able to restart eating 1 day earlier, and this difference was found to be significant. Our data suggest that normalization of serum lipase is not obligatory for enteral nutrition in mild acute pancreatitis.
- Published
- 2010
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