Search

Your search keyword '"Bellin, Melena D"' showing total 50 results
Start Over Author "Bellin, Melena D" Journal pancreas
50 results on '"Bellin, Melena D"'

1. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases

Author

Mastracci, Teresa L, Apte, Minoti, Amundadottir, Laufey T, Alvarsson, Alexandra, Artandi, Steven, Bellin, Melena D, Bernal-Mizrachi, Ernesto, Caicedo, Alejandro, Campbell-Thompson, Martha, Cruz-Monserrate, Zobeida, Ouaamari, Abdelfattah El, Gaulton, Kyle J, Geisz, Andrea, Goodarzi, Mark O, Hara, Manami, Hull-Meichle, Rebecca L, Kleger, Alexander, Klein, Alison P, Kopp, Janel L, Kulkarni, Rohit N, Muzumdar, Mandar D, Naren, Anjaparavanda P, Oakes, Scott A, Olesen, Søren S, Phelps, Edward A, Powers, Alvin C, Stabler, Cherie L, Tirkes, Temel, Whitcomb, David C, Yadav, Dhiraj, Yong, Jing, Zaghloul, Norann A, Sander, Maike, and Pandol, Stephen J

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Pancreatic Cancer, Cancer, Rare Diseases, Diabetes, Metabolic and endocrine, Good Health and Well Being, Humans, Diabetes Mellitus, Islets of Langerhans, Pancreas, Pancreas, Exocrine, Pancreatic Diseases, exocrine pancreas, endocrine pancreas, exocrine-endocrine crosstalk, integrated physiology, interpancreatic communication, AP, acute pancreatitis, AP-D, acute pancreatitis-related diabetes, CCK, cholecystokinin, cCRE, cis-regulatory element, CF, cystic fibrosis, CFRD, cystic fibrosis-related diabetes, CFTR, cystic fibrosis transmembrane conductance regulator, CP, chronic pancreatitis, CP-D, chronic pancreatitis-related diabetes, ECM, extracellular matrix, eIF5A, eukaryotic initiation factor 5A, EPI, exocrine pancreatic insufficiency, GWAS, genome-wide association study, MRI, magnetic resonance imaging, MRCP, magnetic resonance cholangiopancreatography, NIDDK, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, National Institutes of Health, PSC, pancreatic stellate cells, PDAC, pancreatic ductal adenocarcinoma, PDLO, pancreatic-duct-like organoid, PRSS1, trypsinogen, T1D, type 1 diabetes, T2D, type 2 diabetes, Gastroenterology & Hepatology, Clinical sciences
Abstract

AbstractThe "Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases" Workshop was a 1.5-day scientific conference at the National Institutes of Health (Bethesda, MD) that engaged clinical and basic science investigators interested in diseases of the pancreas. This report summarizes the workshop proceedings. The goal of the workshop was to forge connections and identify gaps in knowledge that could guide future research directions. Presentations were segregated into 6 major themes, including (a) Pancreas Anatomy and Physiology; (b) Diabetes in the Setting of Exocrine Disease; (c) Metabolic Influences on the Exocrine Pancreas; (d) Genetic Drivers of Pancreatic Diseases; (e) Tools for Integrated Pancreatic Analysis; and (f) Implications of Exocrine-Endocrine Crosstalk. For each theme, there were multiple presentations followed by panel discussions on specific topics relevant to each area of research; these are summarized herein. Significantly, the discussions resulted in the identification of research gaps and opportunities for the field to address. In general, it was concluded that as a pancreas research community, we must more thoughtfully integrate our current knowledge of the normal physiology as well as the disease mechanisms that underlie endocrine and exocrine disorders so that there is a better understanding of the interplay between these compartments.

Published
2022

2. Rationale and Design for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study

Author

Hart, Phil A, Papachristou, Georgios I, Park, Walter G, Dyer, Anne-Marie, Chinchilli, Vernon M, Afghani, Elham, Akshintala, Venkata S, Andersen, Dana K, Buxbaum, James L, Conwell, Darwin L, Dungan, Kathleen M, Easler, Jeffrey J, Fogel, Evan L, Greenbaum, Carla J, Kalyani, Rita R, Korc, Murray, Kozarek, Richard, Laughlin, Maren R, Lee, Peter J, Maranki, Jennifer L, Pandol, Stephen J, Phillips, Anna Evans, Serrano, Jose, Singh, Vikesh K, Speake, Cate, Tirkes, Temel, Toledo, Frederico GS, Trikudanathan, Vege, Santhi Swaroop, Wang, Ming, Yazici, Cemal, Zaheer, Atif, Forsmark, Christopher E, Bellin, Melena D, and Yadav, Dhiraj

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Diabetes, Acute Disease, Diabetes Mellitus, Type 1, Humans, Incidence, Pancreatitis, Prospective Studies, pancreatogenic diabetes, type 3c diabetes, beta cell, insulin, autoantibody, epidemiology, AP, acute pancreatitis, CP, chronic pancreatitis, DCC, data coordinating center, DM, diabetes mellitus, DREAM, Diabetes RElated to Acute pancreatitis and its Mechanisms, FSIGTT, frequently sampled intravenous glucose tolerance testing, OGTT, oral glucose tolerance testing, MMTT, mixed meal tolerance testing, T1DAPC, Type 1 Diabetes in Acute Pancreatitis Consortium, Gastroenterology & Hepatology, Clinical sciences
Abstract

AbstractAcute pancreatitis (AP) is a disease characterized by an acute inflammatory phase followed by a convalescent phase. Diabetes mellitus (DM) was historically felt to be a transient phenomenon related to acute inflammation; however, it is increasingly recognized as an important late and chronic complication. There are several challenges that have prevented precisely determining the incidence rate of DM after AP and understanding the underlying mechanisms. The DREAM (Diabetes RElated to Acute Pancreatitis and its Mechanisms) Study is a prospective cohort study designed to address these and other knowledge gaps to provide the evidence needed to screen for, prevent, and treat DM after AP. In the following article, we summarize literature regarding the epidemiology of DM after AP and provide the rationale and an overview of the DREAM study.

Published
2022

3. Pancreatic Pain-Knowledge Gaps and Research Opportunities in Children and Adults: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Author

Uc, Aliye, Andersen, Dana K, Apkarian, A Vania, Bellin, Melena D, Colloca, Luana, Drewes, Asbjørn M, Dunbar, Ellyn K, Forsmark, Christopher E, Goodman, Marc T, Kapural, Leonardo, Koob, George F, Palermo, Tonya M, Pandol, Stephen J, Pasricha, Pankaj, Phillips, Anna E, Piomelli, Daniele, Saloman, Jami L, Schwarzenberg, Sarah Jane, Singh, Vikesh K, Sowa, Gwendolyn, Strouse, Thomas, Treisman, Glenn J, Windsor, John A, and Yadav, Dhiraj

Subjects
Humans, Pancreatic Diseases, Abdominal Pain, Biomedical Research, Adult, Child, United States, National Institute of Diabetes and Digestive and Kidney Diseases (U.S.), Pain Management, Cancer, Digestive Diseases, Rare Diseases, Chronic Pain, Neurosciences, Pancreatic Cancer, Pain Research, Aetiology, 2.1 Biological and endogenous factors, pancreatitis, pancreatic cancer, peripheral sensitization, central sensitization, placebo, quantitative sensory testing, Clinical Sciences, Gastroenterology & Hepatology
Abstract

AbstractA workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases to focus on research gaps and opportunities in pancreatic pain. The event was held on July 21, 2021, and structured into 4 sessions: (1) pathophysiology; (2) biomarkers, mediators, and pharmacology of pain; (3) pain assessment; and (4) pain treatment challenges and opportunities. The current state of knowledge was reviewed; many knowledge gaps and research needs were identified that require further investigation. Common themes included the need to better understand the underlying mechanisms of pain in pancreatic diseases, the relationship of visceral neural pathways and central pain centers, the role of behavioral factors and disorders on the perception of pain, and differences in pain perception and processes in children when compared with adults. In addition, the role of genetic risk factors for pain and the mechanisms and role of placebos in pain treatment were discussed. Methods of pain assessment including quantitative sensory testing were examined, as well as the process of central sensitization of pain. Finally, newer approaches to pain management including cognitive behavioral therapy, nerve stimulation, experimental (nonopioid) drugs, and cannabinoid compounds were covered.

Published
2021

4. INternational Study Group of Pediatric Pancreatitis

Author

Uc, Aliye, Perito, Emily R, Pohl, John F, Shah, Uzma, Abu-El-Haija, Maisam, Barth, Bradley, Bellin, Melena D, Ellery, Kate M, Fishman, Douglas S, Gariepy, Cheryl E, Giefer, Matthew J, Gonska, Tanja, Heyman, Melvin B, Himes, Ryan W, Husain, Sohail Z, Maqbool, Asim, Mascarenhas, Maria R, McFerron, Brian A, Morinville, Veronique D, Lin, Tom K, Liu, Quin Y, Nathan, Jaimie D, Rhee, Sue J, Ooi, Chee Y, Sellers, Zachary M, Schwarzenberg, Sarah Jane, Serrano, Jose, Troendle, David M, Werlin, Steven L, Wilschanski, Michael, Zheng, Yuhua, Yuan, Ying, and Lowe, Mark E

Subjects
Clinical Research, Burden of Illness, Mental Health, Digestive Diseases, Depression, Cancer, Pediatric Research Initiative, Pediatric, Oral and gastrointestinal, Good Health and Well Being, Acute Disease, Biomedical Research, Child, Child, Preschool, Cohort Studies, Diabetes Mellitus, Humans, International Agencies, Multicenter Studies as Topic, Observational Studies as Topic, Pancreatic Neoplasms, Pancreatitis, Pancreatitis, Chronic, Research Design, Surveys and Questionnaires, Children, registry, pancreatitis, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer, Clinical Sciences, Gastroenterology & Hepatology
Abstract

We created the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE (INSPPIRE 2) cohort to study the risk factors, natural history, and outcomes of pediatric acute recurrent pancreatitis and chronic pancreatitis (CP). Patient and physician questionnaires collect information on demographics, clinical history, family and social history, and disease outcomes. Health-related quality of life, depression, and anxiety are measured using validated questionnaires. Information entered on paper questionnaires is transferred into a database managed by Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer's Coordinating and Data Management Center. Biosamples are collected for DNA isolation and analysis of most common pancreatitis-associated genes.Twenty-two sites (18 in the United States, 2 in Canada, and 1 each in Israel and Australia) are participating in the INSPPIRE 2 study. These sites have enrolled 211 subjects into the INSPPIRE 2 database toward our goal to recruit more than 800 patients in 2 years. The INSPPIRE 2 cohort study is an extension of the INSPPIRE cohort study with a larger and more diverse patient population. Our goals have expanded to include evaluating risk factors for CP, its sequelae, and psychosocial factors associated with pediatric acute recurrent pancreatitis and CP.

Published
2018

5. Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis

Author

Uc, Aliye, Zimmerman, M Bridget, Wilschanski, Michael, Werlin, Steven L, Troendle, David, Shah, Uzma, Schwarzenberg, Sarah Jane, Rhee, Sue, Pohl, John F, Perito, Emily R, Palermo, Joseph J, Ooi, Chee Y, Liu, Quin, Lin, Tom K, Morinville, Veronique D, McFerron, Brian A, Husain, Sohail Z, Himes, Ryan, Heyman, Melvin B, Gonska, Tanja, Giefer, Matthew J, Gariepy, Cheryl E, Freedman, Steven D, Fishman, Douglas S, Bellin, Melena D, Barth, Bradley, Abu-El-Haija, Maisam, and Lowe, Mark E

Subjects
Diabetes, Digestive Diseases, Obesity, Nutrition, Prevention, Clinical Research, Pediatric, Cardiovascular, Stroke, Cancer, Metabolic and endocrine, Oral and gastrointestinal, Acute Disease, Body Mass Index, Child, Cohort Studies, Disease Progression, Female, Humans, Male, Overweight, Pancreatitis, Pancreatitis, Chronic, Recurrence, Severity of Illness Index, body mass index, children, pancreatitis, Clinical Sciences, Gastroenterology & Hepatology
Abstract

ObjectiveThe aim of this study was to assess the impact of obesity on pediatric acute recurrent pancreatitis or chronic pancreatitis (CP).MethodsWe determined body mass index (BMI) status at enrollment in INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) cohort using CDC criteria for pediatric-specific BMI percentiles. We used the Cochran-Armitage test to assess trends and the Jonckheere-Terpstra test to determine associations.ResultsOf 446 subjects (acute recurrent pancreatitis, n = 241; CP, n = 205), 22 were underweight, 258 normal weight, 75 overweight, and 91 were obese. The BMI groups were similar in sex, race, and age at presentation. Hypertriglyceridemia was more common in overweight or obese. Obese children were less likely to have CP and more likely to have acute inflammation on imaging. Compared with children with normal weight, obese or overweight children were older at first acute pancreatitis episode and diagnosed with CP at an older age. Obese or overweight children were less likely to undergo medical or endoscopic treatment, develop exocrine pancreatic insufficiency, and require total pancreatectomy with islet autotransplantation. Diabetes was similar among all groups.ConclusionsObesity or overweight seems to delay the initial acute pancreatitis episode and diagnosis of CP compared with normal weight or underweight. The impact of obesity on pediatric CP progression and severity deserves further study.

Published
2018

6. Therapeutic Endoscopic Retrograde Cholangiopancreatography in Pediatric Patients With Acute Recurrent and Chronic Pancreatitis

Author

Troendle, David M, Fishman, Douglas S, Barth, Bradley A, Giefer, Matthew J, Lin, Tom K, Liu, Quin Y, Abu-El-Haija, Maisam, Bellin, Melena D, Durie, Peter R, Freedman, Steven D, Gariepy, Cheryl, Gonska, Tanja, Heyman, Melvin B, Himes, Ryan, Husain, Sohail Z, Kumar, Soma, Lowe, Mark E, Morinville, Veronique D, Ooi, Chee Y, Palermo, Joseph, Pohl, John F, Schwarzenberg, Sarah Jane, Werlin, Steven, Wilschanski, Michael, Zimmerman, M Bridget, and Uc, Aliye

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Pediatric, Digestive Diseases, Clinical Research, Acute Disease, Adolescent, Age Factors, Child, Child, Preschool, Cholangiopancreatography, Endoscopic Retrograde, Databases, Factual, Female, Humans, Male, Pancreatitis, Pancreatitis, Chronic, Practice Patterns, Physicians', Recurrence, Stents, Time Factors, Treatment Outcome, bile ducts, bile stent, children, endotherapy, pancreatic ducts, pancreatic stent, Gastroenterology & Hepatology, Clinical sciences
Abstract

ObjectiveThe aim of this study was to characterize utilization and benefit of therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in children with acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP).MethodsFrom August 2012 to February 2015, 301 children with ARP or CP were enrolled in the INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) study. Physicians reported utilization and benefit of therapeutic ERCP at enrollment. Differences were analyzed using appropriate statistical methods.ResultsOne hundred seventeen children (38.9%) underwent at least 1 therapeutic ERCP. The procedure was more commonly performed in children with CP compared with those with ARP (65.8% vs 13.5%, P < 0.0001). Utility of therapeutic ERCP was reported to be similar between ARP and CP (53% vs 56%, P = 0.81) and was found to be helpful for at least 1 indication in both groups (53/99 patients [53.5%]). Predictors for undergoing therapeutic ERCP were presence of obstructive factors in ARP and CP, Hispanic ethnicity, or white race in CP.ConclusionsTherapeutic ERCP is frequently utilized in children with ARP or CP and may offer benefit in selected cases, specifically if ductal obstruction is present. Longitudinal studies are needed to clarify the efficacy of therapeutic ERCP and to explore subgroups that might have increased benefit from such intervention.

Published
2017

8. Preoperative Computerized Tomography and Magnetic Resonance Imaging of the Pancreas Predicts Pancreatic Mass and Functional Outcomes After Total Pancreatectomy and Islet Autotransplant

Author

Young, Michael C, Theis, Jake R, Hodges, James S, Dunn, Ty B, Pruett, Timothy L, Chinnakotla, Srinath, Walker, Sidney P, Freeman, Martin L, Trikudanathan, Arain, Mustafa, Robertson, Paul R, Wilhelm, Joshua J, Schwarzenberg, Sarah J, Bland, Barbara, Beilman, Gregory J, and Bellin, Melena D

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Diabetes, Rare Diseases, Biomedical Imaging, Clinical Research, Autoimmune Disease, Digestive Diseases, Metabolic and endocrine, Adolescent, Adult, Autografts, Female, Humans, Islets of Langerhans Transplantation, Linear Models, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size, Pancreas, Pancreatectomy, Pancreatitis, Chronic, Preoperative Period, Tomography, X-Ray Computed, Treatment Outcome, Young Adult, Gastroenterology & Hepatology, Clinical sciences
Abstract

ObjectivesApproximately two thirds of patients will remain on insulin therapy after total pancreatectomy with islet autotransplant (TPIAT) for chronic pancreatitis. We investigated the relationship between measured pancreas volume on computerized tomography or magnetic resonance imaging and features of chronic pancreatitis on imaging, with subsequent islet isolation and diabetes outcomes.MethodsComputerized tomography or magnetic resonance imaging was reviewed for pancreas volume (Vitrea software) and presence or absence of calcifications, atrophy, and dilated pancreatic duct in 97 patients undergoing TPIAT. Relationship between these features and (1) islet mass isolated and (2) diabetes status at 1-year post-TPIAT were evaluated.ResultsPancreas volume correlated with islet mass measured as total islet equivalents (r = 0.50, P < 0.0001). Mean islet equivalents were reduced by more than half if any one of calcifications, atrophy, or ductal dilatation were observed. Pancreatic calcifications increased the odds of insulin dependence 4.0 fold (1.1, 15). Collectively, the pancreas volume and 3 imaging features strongly associated with 1-year insulin use (P = 0.07), islet graft failure (P = 0.003), hemoglobin A1c (P = 0.0004), fasting glucose (P = 0.027), and fasting C-peptide level (P = 0.008).ConclusionsMeasures of pancreatic parenchymal destruction on imaging, including smaller pancreas volume and calcifications, associate strongly with impaired islet mass and 1-year diabetes outcomes.

Published
2016

9. Type 1 Diabetes in Acute Pancreatitis Consortium: From Concept to Reality

Author

Serrano, Jose, Laughlin, Maren R., Bellin, Melena D., Yadav, Dhiraj, Chinchilli, Vernon M., Andersen, Dana K., Greenbaum, Carla, Kozarek, Richard, Speake, Cate, Lord, Sandra, Irani, Shayan, Linsley, Peter, Kwok, William, Lacy-Hulbert, Adam, Hamerman, Jessica, Bahnson, Henry, Grubb, Brooke, Williams, Cassandra, Ackermann, Sarah, Varner, Kimberly, Goodarzi, Mark O., Pandol, Stephen J., Buxbaum, James, Diniz, Marcio, Goodman, Marc, Hines, O. Joe, Jeon, Christie, Korc, Murray, Li, Debiao, Petrov, Maxim, Pisegna, Joseph, Van Eyk, Jennifer, Vege, Santhi Swaroop, Fogel, Evan, Evans-Molina, Carmella, Tirkes, Temel, Sherman, Stuart, Easler, Jeffrey, Saeed, Zed, Sims, Emily, Oram, Richard, Weedon, Michael, Singh, Vikesh, Sun, Zhaoli, Afghani, Elham, Kalyani, Rita, Jacobs, Michael, Zaheer, Atif, Zhu, Heng, Akshintala, Venkata S., Papachristou, Georgios I., Hart, Phil A., Conwell, Darwin L., Bradley, David, Dungan, Kathleen, Shah, Zarine, Krebs, Zoe, Hazelett, Samantha, Forsmark, Christopher E., Casu, Anna, Hughes, Steven, Pratley, Richard E., Thompson, Martha Campbell, Wasserfall, Clive, Grajo, Joseph, Yazici, Cemal, Layden, Brian, Danielson, Kirstie, Boulay, Brian, Villa, Edward, Mutlu, Ece, Xia, Yinglin, Green, Stefan, Tussing-Humphreys, Lisa, Prabhakar, Bellur, Gaba, Ron, Ratia, Kiira, Daviglus, Martha, Spaggiari, Mario, Grippo, Paul J., Setiawan, Veronica, Keswani, Rajesh, Komanduri, Srinadh, Aadam, Aziz, Bellin, Melena, Trikudanathan, Guru, Fife, Brian, Freeman, Martin, Harindhanavudhi, Tasma, Moran, Antoinette, Spilseth, Benjamin, Hodges, James, Yadav, Dhiraj, Toledo, Frederico G. S., Dasyam, Anil, Phillips, Anna E., Kang, Chae-Ryon, Yechoor, Vijay, Saloman, Jami, Becker, Dorothy, Reynolds, Shari, Hall, Kristin, Stello, Kim, Mays, Melanie, Saul, Melissa, Park, Walter G., Basina, Marina, Habtezion, Aida, Poullos, Peter, Meyer, Everett, Chinchilli, Vernon M., Kong, Lan, Liu, Dajiang, Maranki, Jennifer, McCormick, Jennifer, Pichardo-Lowden, Ariana, Siddiqui, Ayesha, Raja-Khan, Nazia, Wang, Ming, Zhan, Xiang, Bottino, Rita, Faulkner, Georgia, Baab, Kendall Thomas, Dyer, Anne-Marie, Guzman, Jennifer, Holmes, Beth, Baron, Rose, Merchlinski, Aimee, Valencia-Moulton, Paula, Broach, James, and Bradley, David

Published
2022
Full Text
View/download PDF

12. Assessing the Pathophysiology of Hyperglycemia in the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium

Author

Dungan, Kathleen M., Hart, Phil A., Andersen, Dana K., Basina, Marina, Chinchilli, Vernon M., Danielson, Kirstie K., Evans-Molina, Carmella, Goodarzi, Mark O., Greenbaum, Carla J., Kalyani, Rita R., Laughlin, Maren R., Pichardo-Lowden, Ariana, Pratley, Richard E., Serrano, Jose, Sims, Emily K., Speake, Cate, Yadav, Dhiraj, Bellin, Melena D., and Toledo, Frederico G. S.

Published
2022
Full Text
View/download PDF

13. Recruitment and Retention Strategies for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium

Author

Yazici, Cemal, Dyer, Anne-Marie, Conwell, Darwin L., Afghani, Elham, Andersen, Dana K., Basina, Marina, Bellin, Melena D., Boone, Leslie R., Casu, Anna, Easler, Jeffrey J., Greenbaum, Carla J., Hart, Phil A., Jeon, Christie Y., Lee, Peter J., Meier, Shelby, Papachristou, Georgios I., Raja-Khan, Nazia T., Saeed, Zeb I., Serrano, Jose, Yadav, Dhiraj, and Fogel, Evan L.

Published
2022
Full Text
View/download PDF

14. Design and Rationale for the Use of Magnetic Resonance Imaging Biomarkers to Predict Diabetes After Acute Pancreatitis in the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium

Author

Tirkes, Temel, Chinchilli, Vernon M., Bagci, Ulas, Parker, Jason G., Zhao, Xuandong, Dasyam, Anil K., Feranec, Nicholas, Grajo, Joseph R., Shah, Zarine K., Poullos, Peter D., Spilseth, Benjamin, Zaheer, Atif, Xie, Karen L., Wachsman, Ashley M., Campbell-Thompson, Martha, Conwell, Darwin L., Fogel, Evan L., Forsmark, Christopher E., Hart, Phil A., Pandol, Stephen J., Park, Walter G., Pratley, Richard E., Yazici, Cemal, Laughlin, Maren R., Andersen, Dana K., Serrano, Jose, Bellin, Melena D., and Yadav, Dhiraj

Published
2022
Full Text
View/download PDF

15. Standard Operating Procedures for Biospecimen Collection, Processing, and Storage: From the Type 1 Diabetes in Acute Pancreatitis Consortium

Author

Wasserfall, Clive, Dyer, Anne-Marie, Speake, Cate, Andersen, Dana K., Baab, Kendall Thomas, Bellin, Melena D., Broach, James R., Campbell-Thompson, Martha, Chinchilli, Vernon M., Lee, Peter J., Park, Walter G., Pratley, Richard E., Saloman, Jami L., Sims, Emily K., Tang, Gong, Yadav, Dhiraj, Yazici, Cemal, and Conwell, Darwin L.

Published
2022
Full Text
View/download PDF

16. Evaluating the Immunopathogenesis of Diabetes After Acute Pancreatitis in the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium

Author

Casu, Anna, Grippo, Paul J., Wasserfall, Clive, Sun, Zhaoli, Linsley, Peter S., Hamerman, Jessica A., Fife, Brian T., Lacy-Hulbert, Adam, Toledo, Frederico G.S., Hart, Phil A., Papachristou, Georgios I., Bellin, Melena D., Yadav, Dhiraj, Laughlin, Maren R., Goodarzi, Mark O., and Speake, Cate

Published
2022
Full Text
View/download PDF

23. A Study on the Effect of Patient Characteristics, Geographical Utilization, and Patient Outcomes for Total Pancreatectomy Alone and Total Pancreatectomy With Islet Autotransplantation in Patients With Pancreatitis in the United States

Author

Lara, Luis F., Bellin, Melena D., Ugbarugba, Emmanuel, Nathan, Jaimie D., Witkowski, Piotr, Wijkstrom, Martin, Steel, Jennifer L., Smith, Kerrington D., Singh, Vikesh K., Schwarzenberg, Sarah J., Pruett, Timothy L., Naziruddin, Bashoo, Long-Simpson, Leslie, Kirchner, Varvara A., Gardner, Timothy B., Freeman, Martin L., Dunn, Ty B., Chinnakotla, Srinath, Beilman, Gregory J., Adams, David B., Morgan, Katherine A., Abu-El-Haija, Maisam A., Ahmad, Syed, Posselt, Andrew M., Hughes, Michael G., and Conwell, Darwin L.

Published
2019
Full Text
View/download PDF

25. Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniC DiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis: Rationale and Methodology for the DETECT Study From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer

Author

Hart, Phil A., Andersen, Dana K., Mather, Kieren J., Castonguay, Alicia C., Bajaj, Mandeep, Bellin, Melena D., Bradley, David, Contreras, Noemy, Habtezion, Aida, Korc, Murray, Kudva, Yogish, Petrov, Maxim S., Whitcomb, David C., Yadav, Dhiraj, Yuan, Ying, Rinaudo, Jo Ann S., Srivastava, Sudhir, Serrano, Jose, and Goodarzi, Mark O.

Published
2018
Full Text
View/download PDF

33. Recruitment and Retention Strategies for the D iabetes RE lated to A cute Pancreatitis and Its M echanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium.

Author

Yazici, Cemal, Dyer, Anne-Marie, Conwell, Darwin L., Afghani, Elham, Andersen, Dana K., Basina, Marina, Bellin, Melena D., Boone, Leslie R., Casu, Anna, Easler, Jeffrey J., Greenbaum, Carla J., Hart, Phil A., Jeon, Christie Y., Lee, Peter J., Meier, Shelby, Papachristou, Georgios I., Raja-Khan, Nazia T., Saeed, Zeb I., Serrano, Jose, and Yadav, Dhiraj

Published
2022
Full Text
View/download PDF

34. Evaluating the Immunopathogenesis of Diabetes After Acute Pancreatitis in the D iabetes RE lated to A cute Pancreatitis and Its M echanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium.

Author

Casu, Anna, Grippo, Paul J., Wasserfall, Clive, Sun, Zhaoli, Linsley, Peter S., Hamerman, Jessica A., Fife, Brian T., Lacy-Hulbert, Adam, Toledo, Frederico G.S., Hart, Phil A., Papachristou, Georgios I., Bellin, Melena D., Yadav, Dhiraj, Laughlin, Maren R., Goodarzi, Mark O., and Speake, Cate

Published
2022
Full Text
View/download PDF

35. Assessing the Pathophysiology of Hyperglycemia in the D iabetes RE lated to A cute Pancreatitis and Its M echanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium.

Author

Dungan, Kathleen M., Hart, Phil A., Andersen, Dana K., Basina, Marina, Chinchilli, Vernon M., Danielson, Kirstie K., Evans-Molina, Carmella, Goodarzi, Mark O., Greenbaum, Carla J., Kalyani, Rita R., Laughlin, Maren R., Pichardo-Lowden, Ariana, Pratley, Richard E., Serrano, Jose, Sims, Emily K., Speake, Cate, Yadav, Dhiraj, Bellin, Melena D., and Toledo, Frederico G. S.

Published
2022
Full Text
View/download PDF

36. Age and Disease Duration Impact Outcomes of Total Pancreatectomy and Islet Autotransplant for PRSS1 Hereditary Pancreatitis

Author

Bellin, Melena D., primary, Prokhoda, Polina, additional, Hodges, James S., additional, Schwarzenberg, Sarah J., additional, Freeman, Martin L., additional, Dunn, Ty B., additional, Wilhelm, Joshua J., additional, Pruett, Timothy L., additional, Kirchner, Varvara A., additional, Beilman, Gregory J., additional, and Chinnakotla, Srinath, additional

Published
2018
Full Text
View/download PDF

38. The Association of Smoking and Alcohol Abuse on Anxiety and Depression in Patients With Recurrent Acute or Chronic Pancreatitis Undergoing Total Pancreatectomy and Islet Autotransplantation

Author

Lara, Luis F., Wastvedt, Solvejg, Hodges, James S., Witkowski, Piotr, Wijkstrom, Martin, Walsh, R. Matthew, Singh, Vikesh K., Schwarzenberg, Sarah J., Pruett, Timothy L., Posselt, Andrew, Naziruddin, Bashoo, Nathan, Jaimie D., Morgan, Katherine A., Mitchell, Rebecca, Kirchner, Varvara A., Mokshagundam, SriPrakash L., Hatipoglu, Betul, Gardner, Timothy B., Freeman, Martin L., Chinnakotla, Srinath, Beilman, Gregory J., Abu-El-Haija, Maisam, Conwell, Darwin L., and Bellin, Melena D.

Published
2021
Full Text
View/download PDF

39. Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities

Author

Uc, Aliye, primary, Andersen, Dana K., additional, Bellin, Melena D., additional, Bruce, Jason I., additional, Drewes, Asbjørn M., additional, Engelhardt, John F., additional, Forsmark, Christopher E., additional, Lerch, Markus M., additional, Lowe, Mark E., additional, Neuschwander-Tetri, Brent A., additional, O'Keefe, Stephen J., additional, Palermo, Tonya M., additional, Pasricha, Pankaj, additional, Saluja, Ashok K., additional, Singh, Vikesh K., additional, Szigethy, Eva M., additional, Whitcomb, David C., additional, Yadav, Dhiraj, additional, and Conwell, Darwin L., additional

Published
2016
Full Text
View/download PDF

41. Evaluation of a Mixed Meal Test for D iagnosis and Characterization of Pancr E a T og E ni C Diabe T es Secondary to Pancreatic Cancer and Chronic Pancreatitis: Rationale and Methodology for the DETECT Study From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer

Author

Hart, Phil A., Andersen, Dana K., Mather, Kieren J., Castonguay, Alicia C., Bajaj, Mandeep, Bellin, Melena D., Bradley, David, Contreras, Noemy, Habtezion, Aida, Korc, Murray, Kudva, Yogish, Petrov, Maxim S., Whitcomb, David C., Yadav, Dhiraj, Yuan, Ying, Rinaudo, Jo Ann S., Srivastava, Sudhir, Serrano, Jose, and Goodarzi, Mark O.

Published
2018
Full Text
View/download PDF

42. IN ternational S tudy Group of P ediatric P ancreatitis: I n Search for a Cu RE Cohort Study: Design and Rationale for INSPPIRE 2 From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer.

Author

Uc, Aliye, Perito, Emily R., Pohl, John F., Shah, Uzma, Abu-El-Haija, Maisam, Barth, Bradley, Bellin, Melena D., Ellery, Kate M., Fishman, Douglas S., Gariepy, Cheryl E., Giefer, Matthew J., Gonska, Tanja, Heyman, Melvin B., Himes, Ryan W., Husain, Sohail Z., Maqbool, Asim, Mascarenhas, Maria R., McFerron, Brian A., Morinville, Veronique D., and Lin, Tom K.

Published
2018
Full Text
View/download PDF

44. Total Pancreatectomy With Islet Autotransplantation

Author

Bellin, Melena D., primary, Gelrud, Andres, additional, Arreaza-Rubin, Guillermo, additional, Dunn, Ty B., additional, Humar, Abhinav, additional, Morgan, Katherine A., additional, Naziruddin, Bashoo, additional, Rastellini, Cristiana, additional, Rickels, Michael R., additional, Schwarzenberg, Sarah J., additional, and Andersen, Dana K., additional

Published
2014
Full Text
View/download PDF

45. Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniCDiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis

Author

Hart, Phil A., Andersen, Dana K., Mather, Kieren J., Castonguay, Alicia C., Bajaj, Mandeep, Bellin, Melena D., Bradley, David, Contreras, Noemy, Habtezion, Aida, Korc, Murray, Kudva, Yogish, Petrov, Maxim S., Whitcomb, David C., Yadav, Dhiraj, Yuan, Ying, Rinaudo, Jo Ann S., Srivastava, Sudhir, Serrano, Jose, and Goodarzi, Mark O.

Abstract

Pancreatogenic diabetes mellitus is most commonly the result of chronic pancreatitis but can also occur secondary to pancreatic cancer. The early identification of pancreatogenic diabetes and distinction from the more prevalent type 2 diabetes are clinically significant; however, currently, there is no validated method to differentiate these diabetes subtypes. We describe a study, “Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniC DiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis: the DETECT study,” that seeks to address this knowledge gap. The DETECT study is a multicenter study that will examine differences in hormone and glucose excursions after a mixed meal test. The study will also create a biorepository that will be used to evaluate novel diagnostic biomarkers for differentiating these diabetes subtypes.

Published
2018
Full Text
View/download PDF

47. Islet Autotransplantation to Preserve Beta Cell Mass in Selected Patients With Chronic Pancreatitis and Diabetes Mellitus Undergoing Total Pancreatectomy

Author

Bellin, Melena D., primary, Beilman, Gregory J., additional, Dunn, Ty B., additional, Pruett, Timothy L., additional, Chinnakotla, Srinath, additional, Wilhelm, Joshua J., additional, Ngo, Anh, additional, Radosevich, David M., additional, Freeman, Martin L., additional, Schwarzenberg, Sarah J., additional, Balamurugan, A. N., additional, Hering, Bernhard J., additional, and Sutherland, David E. R., additional

Published
2013
Full Text
View/download PDF

50. Heterogeneity in Pancreatitis: Recognizing Heterogeneity and Its Role in the Management of Pancreatitis. Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Author

Bellin MD, Andersen DK, Akshintala V, Born D, Coghill RC, Easler J, Fogel EL, Forsmark CE, Freeman AJ, Hughes SJ, Jensen A, Liran O, Martin L, Pandol SJ, Palermo TM, Papachristou GI, Park WG, Phillips AE, Schwarzenberg SJ, Singh VK, Toledo FGS, VanDalfsen J, Whitcomb DC, Wu B, and Yadav D

Abstract

Abstract: Both the clinical management and study of recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) is complicated by significant heterogeneity in the etiology, mechanisms, symptoms, and complications of pancreatitis. The National Institutes of Diabetes and Digestive and Kidney Disease (NIDDK) recently convened a workshop to address current knowledge and knowledge gaps in the field. Preclinical models that better replicate human disease are important for development of new therapies. Pain is often the most common and most difficult symptom to treat, as the causes are multifactorial and effective treatment may vary depending on whether pain is neuropathic or nociceptive in origin, and the placebo effect can complicate evaluation of the efficacy of medical and procedural interventions. Novel technologies like functional MRI and virtual reality may offer novel means for assessing and treating pain, respectively. Clinical trial designs will need to consider best approaches to addressing the heterogeneity of CP, including careful attention to designing eligibility criteria, and establishing accepted and validated core outcomes criteria for the field. The latter may be informed by consensus in pain research. Recruitment of participants into clinical trials has been challenging, often requiring multiple centers. Establishment of a clinical trials network would facilitate greater opportunities for therapeutic trials in pancreatitis., Competing Interests: Conflict of Interest: DY is a consultant for Pfizer, Inc. and has received research support from Abbvie Pharmaceuticals., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results