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Interactions between human societies and the environment that they inhabit have been a controversial topic in archaeology for at least the past fifty years. Currently, modern theoretical approaches take this subject as a key issue in their research agenda. This paper presents a review of the main outcomes of several archaeological and multidisciplinary South American projects related to this theme. The case-studies discussed here are all located within arid settings, and can be grouped into three broad geographic areas: Puna (or Altiplano) of northwestern Argentina, Cuyo (west-central Argentina), and southern Patagonia. These regions cover a wide latitudinal range extending from 22° to 52° S. They were selected for comparison due to environmental similarities, and a common record of past climate impacts mainly related to the Medieval Climatic Anomaly (MCA) and the Little Ice Age (LIA). Although the impacts of these climatic changes were locally heterogeneous in their intensity and the quality of the available information is regionally variable, they provide a base-line for comparison and supra-regional integration. The integration of archaeological and palaeoenvironmental data on this broad supra-regional spatial scale allows us to identify interesting historical trajectories associated with particular time periods. As an example, there are some spatial rearrangements of large populations during the MCA, in the three areas. Additionally, there are variable patterns in the changes associated with the different social contexts that impose specific demographic and economic constraints. Finally, this study sets the basis for new questions and provides a guide to the methodological and theoretical issues that we need to address in order to answer them. [Copyright &y& Elsevier]