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Abstract: Argentina is a special place to study Late Palaeozoic life and environmental change because of the excellent exposures of Late Palaeozoic sedimentary sequences. In particular, Patagonia has an almost continuous Late Palaeozoic succession containing well-preserved faunal assemblages characterized by both strong endemism and distinctive palaeobiogeographic links to Australia and northeast Asia. In this contribution an overview of the current knowledge of the invertebrate faunas of Patagonia and their biostratigraphic and palaeobiogeographic significance are presented, along with comments on the future prospects of research in the light of new findings. The Late Palaeozoic outcrops in central-western Patagonia belong to the Tepuel–Genoa Basin (Chubut province, Argentina), then located in southwestern Gondwana during the Late Palaezoic. In this basin the succession is >6000m thick, and constitutes a continuous and complete succession from the Lower Carboniferous to lower Permian. As such, it has the potential to serve as an important reference section for regional and intercontinental correlations. The marine Late Palaeozoic of Patagonia has yielded abundant and well-preserved representatives of most invertebrate groups: brachiopods, bivalves, gastropods, cephalopods, hyolithids, pelmatozoans, ostracods and cnidarians. Recently, studies of the Patagonian faunas have resulted in different opinions on the ages of the faunas. Biostratigraphic correlation is complex due to strong faunal provincialism. For this reason, there are several hypotheses concerning the biostratigraphic zonation in the basin. Since 1920, when studies of Late Palaeozoic strata in Patagonia were first carried out, numerous papers on stratigraphic, palaeogeographic and taxonomic subjects have been published, but our knowledge of Carboniferous–Permian fossils from the Tepuel–Genoa Basin is still incomplete. At present, we are attempting to integrate and calibrate the different faunal associations with a view to achieving a unified biostratigraphic biozonation scheme and hence a much improved understanding of the palaeobiogeographic relationship of Patagonian faunas with those from western Argentina and other continents. Currently, detailed stratigraphic and palaeontological research is being done in the type section of the Tepuel–Genoa Basin. The aim of our studies is to integrate all partial sequences exposed throughout the basin and to propose a biostratigraphic chart based on key invertebrate taxa. Once this goal is achieved, a global correlation can be conducted, especially with other sections in Gondwana and the Arctic. [Copyright &y& Elsevier]