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Saxifraga flagellaris commonly known as spider plant or whiplash saxifrage is found all over the world in high mountain areas. In Pakistan, it is found in the hilly areas of Swat. The current research work was designed to find the anticancer, antioxidant, and phytotoxic potential of Saxifraga flagellaris WILLD. Five different fractions of Saxifraga flagellaris were tested for phytotoxic, antioxidant, and anticancer potential. For the determination of phytotoxicity potential, Lactuca sativa was used as a test plant against the crude extracts (10, 20, and 40 mg) of the plant. The phytotoxicity of the plant was remarkable and inhibited the growth of L. sativa. The antioxidant properties of the plant were very much significant and showed a very low IC50 value against DPPH, which indicated the high scavenging potential. Among the tested fractions, DCM (8.52±0.121μg/ml) and Cr. Methanol fractions (9.32±0.102μg/ml) showed promising results. The anticancer activity of DCM fraction by using MTT bioassay against cancer cell line (Colon cancer cells: HT-29) inhibited the cancer cell growth up to 90%. [ABSTRACT FROM AUTHOR]