1,126 results on '"NARCOTICS"'
Search Results
2. Evaluation of an Opioid Overdose Composite Risk Score Cutoff in Active Duty Military Service Members.
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Dunham, Jacob R, Highland, Krista B, Costantino, Ryan C, Rutter, W Cliff, Rittel, Alexander G, Kazanis, William H, and Palmrose, Gregory H
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NARCOTICS , *ANTIDEPRESSANTS , *PREDICTIVE tests , *HOSPITAL emergency services , *CONFIDENCE intervals , *RESEARCH methodology evaluation , *RESEARCH methodology , *RETROSPECTIVE studies , *ACQUISITION of data , *CASE-control method , *RISK assessment , *MEDICAL records , *HOSPITAL care , *DESCRIPTIVE statistics , *GENETIC techniques , *SENSITIVITY & specificity (Statistics) , *MILITARY personnel , *OPIOID abuse , *DOSAGE forms of drugs ,DRUG overdose risk factors - Abstract
Objective To evaluate the current cutoff score and a recalibrated adaptation of the Veterans Health Administration (VHA) Risk Index for Serious Prescription Opioid-Induced Respiratory Depression or Overdose (RIOSORD) in active duty service members. Design Retrospective case-control. Setting Military Health System. Subjects Active duty service members dispensed ≥ 1 opioid prescription between January 1, 2018, and December 31, 2019. Methods Service members with a documented opioid overdose were matched 1:10 to controls. An active duty-specific (AD) RIOSORD was constructed using the VHA RIOSORD components. Analyses examined the risk stratification and predictive characteristics of two RIOSORD versions (VHA and AD). Results Cases (n = 95) were matched with 950 controls. Only 6 of the original 17 elements were retained in the AD RIOSORD. Long-acting or extended-release opioid prescriptions, antidepressant prescriptions, hospitalization, and emergency department visits were associated with overdose events. The VHA RIOSORD had fair performance (C-statistic 0.77, 95% CI 0.75, 0.79), while the AD RIOSORD did not demonstrate statistically significant performance improvement (C-statistic 0.78, 95% CI, 0.77, 0.80). The DoD selected cut point (VHA RIOSORD > 32) only identified 22 of 95 ORD outcomes (Sensitivity 0.23), while an AD-specific cut point (AD RIOSORD > 16) correctly identified 53 of 95 adverse events (Sensitivity 0.56). Conclusions Results highlight the need to continually recalibrate predictive models and to consider multiple measures of performance. Although both models had similar overall performance with respect to the C-statistic, an AD-specific index threshold improves sensitivity. The calibrated AD RIOSORD does not represent an end-state, but a bridge to a future model developed on a wider range of patient variables, taking into consideration features that capture both care received, and care that was not received. [ABSTRACT FROM AUTHOR]
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- 2022
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3. Defining "Doctor Shopping" with Dispensing Data: A Scoping Review.
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Delcher, Chris, Bae, Jungjun, Wang, Yanning, Doung, Michelle, Fink, David S, and Young, Henry W
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NARCOTICS , *DATABASES , *MEDICAL information storage & retrieval systems , *SYSTEMATIC reviews , *DESCRIPTIVE statistics , *PHYSICIANS , *LITERATURE reviews , *PAIN management - Abstract
Background "Doctor shopping" typically refers to patients that seek controlled substance prescriptions from multiple providers with the presumed intent to obtain these medications for non-medical use and/or diversion. The purpose of this scoping review is to document and examine the criteria used to identify "doctor shopping" from dispensing data in the United States. Methods A scoping review was conducted on "doctor shopping" or analogous terminology from January 1, 2000, through December 31, 2020, using the Web of Science Core Collection (seven citation indexes). Our search was limited to the United States only, English-language, peer-reviewed and US federal government studies. Studies without explicit "doctor shopping" criteria were excluded. Key components of these criteria included the number of prescribers and dispensers, dispensing period, and drug class (e.g. opioids). Results Of 9,845 records identified, 95 articles met the inclusion criteria and our pool of studies ranged from years 2003 to 2020. The most common threshold-based or count definition was (≥4 Prescribers [P] AND ≥4 Dispensers [D]) (n = 12). Thirty-three studies used a 365-day detection window. Opioids alone were studied most commonly (n = 69), followed by benzodiazepines and stimulants (n = 5 and n = 2, respectively). Only 39 (41%) studies provided specific drug lists with active ingredients. Conclusion Relatively simple P x D criteria for identifying "doctor shopping" are still the dominant paradigm with the need for ongoing validation. The value of P x D criteria may change through time with more diverse methods applied to dispensing data emerging. [ABSTRACT FROM AUTHOR]
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- 2022
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4. Application and Clinical Value of Definitive Drug Monitoring in Pain Management and Addiction Medicine.
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Rosano, Thomas G, Wood, Michelle, Hooten, W Michael, Rumberger, John M, Fudin, Jeffrey, and Argoff, Charles E
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DRUG addiction , *ANTIDEPRESSANTS , *NARCOTICS , *ANALGESICS , *RETROSPECTIVE studies , *DRUG use testing , *IMMUNOASSAY , *DRUG monitoring , *DRUGS , *DESCRIPTIVE statistics , *URINALYSIS , *PATIENT compliance , *DIAGNOSTIC errors , *PAIN management , *METABOLITES , *ANTIPSYCHOTIC agents - Abstract
Objective To assess routine application and clinical value of definitive urine drug monitoring (UDM) for drug detection, inconsistent drug use, and prescription adherence, along with a comparison to immunoassay screening (IAS). Methods Direct-to-definitive UDM performance was analyzed retrospectively in 5000 patient specimens. Drug findings, medication inconsistencies, and detection sensitivity were assessed, and definitive UDM versus IAS monitoring was studied. Results Definitive testing resulted in 18,793 drug findings with 28,403 positive drug and metabolite tests. Definitive testing expanded monitoring with 11,396 drug findings that would not be tested by IAS. The opioids accounted for the highest frequency of inconsistent positive drug-use findings, at 12%. Conversely, inconsistent negative drug findings, used as an index of prescription non-adherence, were determined in 1,751 of 15,409 monitored medications and included a high frequency of antidepressants and antipsychotics inconsistencies. Direct comparison of definitive UDM and IAS showed false-positives by IAS as well as a high rate of false-negatives that would be missed using current confirmation protocols. Conclusions Results from routine application of direct-to-definitive UDM demonstrate the clinical value of drug-use identification and the objective evaluation of inconsistencies in drug misuse and medication adherence in pain management and addiction medicine practice. Without conversion to direct-to-definitive UDM, continuing use of IAS will limit the scope of drugs being tested, will result in an indeterminate rate of false negatives and will require confirmation testing to eliminate the reporting of false-positive IAS tests. The findings in this study provide evidence-based support for recommended use of a direct-to-definitive drug testing protocol. [ABSTRACT FROM AUTHOR]
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- 2022
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5. Effectiveness, Safety, and Tolerability of Nabiximols Oromucosal Spray vs Typical Oral Long-Acting Opioid Analgesics in Patients with Severe Neuropathic Back Pain: Analysis of 6-Month Real-World Data from the German Pain e-Registry.
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Ueberall, Michael A, Silván, Carlos Vila, Essner, Ute, and Mueller-Schwefe, Gerhard H H
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NARCOTICS , *LUMBAR pain , *DRUG efficacy , *CHRONIC pain , *AEROSOLS , *DRUG tolerance , *PERIPHERAL neuropathy , *CONFIDENCE intervals , *ANALGESICS , *ORAL drug administration , *FUNCTIONAL status , *RETROSPECTIVE studies , *HEALTH outcome assessment , *SEVERITY of illness index , *CONTROLLED release preparations , *DESCRIPTIVE statistics - Abstract
Objective To compare the effectiveness, safety, and tolerability of add-on nabiximols (NBX) oromucosal spray vs typical oral long-acting opioid (LAO) analgesics in patients with severe (± chronic) peripheral neuropathic back pain poorly responsive to other treatments. Methods Retrospective analysis of anonymized, propensity score–matched data from the German Pain e-Registry of adult outpatients who initiated NBX or LAO between March 2017 and March 2020. Results Data were analyzed from propensity score–matched patients treated with NBX (n = 655) or LAO (n = 655): mean age ≈51 years; 57% female; mean pain duration ≈2.6 years; chronic pain 61%; severe dysfunctional pain 93%. At 6 months, NBX was noninferior to LAO for overall symptom relief, based on the least-squares mean difference between cohorts in change from baseline in patient-reported, pain-related aggregated nine-item scale scores (−27.84%; 95% confidence interval [CI] −29.71 to −25.96; P < 0.001) and individual pain-related scale scores. Subsequent prespecified superiority analysis of the primary endpoint showed that NBX was superior to LAO: all secondary endpoints measuring symptoms of pain and physical function improved significantly with NBX and LAO, with between-group differences favoring NBX (all P < 0.001). Fewer patients treated with NBX than LAO experienced treatment-related adverse events (25.5% vs 76.0%; P < 0.001) or discontinued treatment because of treatment-related adverse events (7.9% vs 29.3%; P < 0.001). Conclusion Within study limitations (e.g. observational design, all potential biases), add-on NBX was superior to and better tolerated than add-on treatment with typical oral LAO analgesics in patients with neuropathic back pain inadequately controlled by recommended/established systemic therapies. [ABSTRACT FROM AUTHOR]
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- 2022
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6. Effect of Reducing Intravenous Push Opioid Use on Hospital Medicine Patients' Pain Experience During Hospitalization.
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Smith, G Randy, Ramalingam, Sridevi, Zhou, Shuhan, Yeh, Chen, Lee, Jungwha, and O'Leary, Kevin J
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PAIN & psychology , *NARCOTICS , *LENGTH of stay in hospitals , *EVALUATION of human services programs , *INTRAVENOUS therapy , *PSYCHOLOGY of hospital patients , *ACADEMIC medical centers , *ANALGESICS , *PATIENT satisfaction , *DISEASE incidence , *RETROSPECTIVE studies , *TERTIARY care , *NALOXONE , *URBAN hospitals , *HOSPITAL care , *HEALTH care teams , *DRUGS , *DESCRIPTIVE statistics , *CRITICAL care medicine , *PATIENT safety , *DISCHARGE planning , *LONGITUDINAL method - Abstract
Objective To determine the efficacy of a program to limit the use of the intravenous (IV) push route for opioids on the experience of pain by inpatients and on associated safety events. Design Retrospective cohort study. Setting Two inpatient general medicine floor units at an urban tertiary care academic medical center. Subjects 4,752 inpatient opioid recipients. Methods Patients in one unit were exposed to a multidisciplinary intervention to limit the prescription of opioids via the IV push route, with the other unit used as a control unit. The primary study outcome was the mean numeric pain score per patient during the hospital stay. Secondary measures included the hospital length of stay and postdischarge patient satisfaction. Fidelity measures included the percentage of the patient population exposed to each opioid administration route and the amount of opioid administered per route. Safety measures included patient disposition, transfer to intensive care, and incidence of naloxone administration. Results The intervention was successful in decreasing both the percentage of patients exposed to IV push opioids and the amount of opioid administered via the IV push route, but no associated changes in other study outcomes were identified. Conclusions For the treatment of acute pain in medical inpatients, no evidence of benefit or harm was identified in relation to an increase or decrease in the use of the IV push opioid route. [ABSTRACT FROM AUTHOR]
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- 2022
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7. Effect of Erector Spinae Block versus Serratus Plane Block on Pain Scores and Diaphragmatic Excursion in Multiple Rib Fractures. A Prospective Randomized Trial.
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Malla, Dina Ahmed El, Helal, Rehab Abd El fattah, Zidan, Tamer Atef Mohamed, and Mourad, Mona Blough El
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DIAPHRAGM innervation , *EVALUATION of medical care , *NARCOTICS , *SERRATUS anterior muscles , *PAIN measurement , *ACADEMIC medical centers , *ULTRASONIC imaging , *ANALGESIA , *CONFIDENCE intervals , *PAIN , *DEXAMETHASONE , *BUPIVACAINE , *TIME , *NERVE block , *ERECTOR spinae muscles , *RANDOMIZED controlled trials , *BLIND experiment , *CLINICAL medicine , *DESCRIPTIVE statistics , *RIB fractures , *EPIDURAL injections , *DATA analysis software , *LONGITUDINAL method , *POSTOPERATIVE pain , *PATIENT safety - Abstract
Objectives We aimed to investigate whether ultrasound guided erector spinae plane block and serratus anterior plane block would provide effective and safe analgesia in patients with fracture ribs, and to detect their effects on diaphragmatic excursion in such cases. Design Prospective double-blind randomized study Settings Tanta University Hospitals Subject Fifty adult patients ASA I, II with fracture ribs. Methods Patients were randomized to receive either ultrasound guided erector spinae block (Group I) or serratus plane block (Group II) with injection of 19 ml bupivacaine 0.25% plus 1 ml dexamethasone (4 mg). Pain scores, 24 hour total analgesic requirements, diaphragmatic excursion and incidence of adverse events were recorded. Results At rest and dynamic pain scores were significantly lower in Group I as compared to Group II from 2 hour up to 24 hour post block [median differences (95% CI): −1 (−0.9999; 0.0002), −1 (−0.9999; 0.0002), −1 (−0.9998; 0.0003), −1(−1.000;−0.000) and −1(−2.0000;−1.0000), −1(−0.9998;−0.0001), −1(−1.0001;−1.0002), −1(−2.000; 0.000), respectively], with a significant reduction in 24 hour opioid consumption in Group I in comparison to Group II (P = .004*). Diaphragmatic excursion showed a significant improvement in Group I when compared to Group II at 2, 6, 12, and 24 hour after the block (P = .024*,.038*,.027*,.042* correspondingly). No adverse events were noted. Conclusions Both erector spinae block and serratus plane block provided safe and effective pain relief in traumatic rib fractures. Although the erector spinae group displayed significantly reduced pain scores, decreased analgesic needs and improved diaphragmatic excursion as compared to serratus group, nevertheless, this was of no clinical significance. [ABSTRACT FROM AUTHOR]
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- 2022
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8. Short-Term Lidocaine Infusion as a Nonsedative Option to Maintain Ventilator Synchrony During Opioid Tapering in a COVID-19 Patient.
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Barman, Ross, Clark, Kathryn, and Olatoye, Oludare
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LIDOCAINE , *NARCOTICS , *COVID-19 , *ANALGESICS , *MECHANICAL ventilators , *ARTIFICIAL respiration , *DRUG therapy - Abstract
The article presents the discussion on the use of short-term lidocaine infusion for maintaining adequate analgesia and ventilator synchrony during high-dose opioid tapering. Topics include COVID-19 manifested varying levels of severity and patients afflicted with severe disease often required admission to the intensive care unit (ICU); and intubated patients undergoing spontaneous breathing trials (SBTs) for predicting the readiness for eventual extubation.
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- 2022
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9. Fewer Opioids but More Benzodiazepines? Prescription Trends by Specialty in Response to the Implementation of Michigan's Opioid Laws.
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Danagoulian, Shooshan, King, Andrew, Mangan, Kyle, Tarchick, John, and Dolcourt, Bram
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CONTROLLED substance laws , *SUBSTANCE abuse risk factors , *NARCOTICS , *HOSPITALS , *HOSPITAL emergency services , *LORAZEPAM , *CONFIDENCE intervals , *ANALGESICS , *MOTIVATION (Psychology) , *OPERATIVE surgery , *RETROSPECTIVE studies , *REGRESSION analysis , *BENZODIAZEPINES , *MORPHINE , *CRITICAL care medicine , *DRUG prescribing , *PHYSICIAN practice patterns , *ELECTRONIC health records , *PHYSICIANS , *MEDICAL specialties & specialists , *TRANQUILIZING drugs , *EMERGENCY medicine - Abstract
Objectives To characterize the effects of Michigan's controlled substance legislation on acute care prescriber behavior by specialty, in a single hospital system. Design A retrospective study of opioid and benzodiazepine prescription records from a hospital electronic medical record system between August 1, 2016, and March 31, 2019, in Detroit, Michigan. Setting Discharges from inpatient and emergency department visits. Intervention Evaluating the impact of implementation of state controlled substance legislation, comparing prescriptions by physicians before, upon, and after June 1, 2018, using regression discontinuity analysis. Methods Total daily prescriptions of opioids and total daily prescriptions of benzodiazepine by physicians in the hospital system. Prescriptions were converted to morphine and lorazepam equivalents for comparability. Results We find 38.5% (95% confidence interval [CI] : 74.1% – 2.9%) decrease of prescription in milligrams of opioid equivalents attributable to implementation of legislation. The main catalyst of the decrease was emergency medicine which experienced 63.9% (95% CI: 109.7%–18.0%) decrease in milligrams of opioid equivalent prescriptions, while surgery increased prescriptions. Though we do not find any statistically significant changes in prescriptions of milligram equivalent of benzodiazepines, we estimate 43.1% (95% CI: 82.6%–3.7%) decrease in count of these prescriptions, implying a significant increase in average dosage of prescriptions. Conclusions The introduction of new regulatory requirements for the prescription of controlled substances led to a general decrease in morphine equivalent milligrams prescribed in most specialties, though it may have increased the dosage of benzodiazepine prescriptions. The change in prescription behavior could be motivated by regulatory hassle or by change in attitude towards opioid prescriptions and increased recognition of opioid use disorder. [ABSTRACT FROM AUTHOR]
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- 2022
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10. Conflicts of Interest Among Authors of Systematic Reviews Regarding the Management of Chronic Non-Cancer Pain with Opioids Analgesics.
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Polson, Connor, Siex, Parker, Anderson, J Michael, Weaver, Michael, Roberts, Will, Hartwell, Micah, and Vassar, Matt
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CHRONIC pain , *NARCOTICS , *AUTHORS , *MEDICAL information storage & retrieval systems , *SYSTEMATIC reviews , *ANALGESICS , *RESEARCH ethics , *CONFLICT of interests , *DISEASE prevalence , *MEDLINE , *RESEARCH bias - Abstract
Objective We sought to determine whether author conflict of interest (disclosed or undisclosed) or industry sponsorship influenced the favorability of reporting of systematic reviews and meta-analyses investigating the use of opioid analgesics for the management of chronic non-cancer pain. Methods Our search included the MEDLINE (Ovid) and Embase (Ovid) databases. Study sponsorship was determined using the funding statement provided in each systematic review. Author COI information was extracted from the COI disclosure statement. This information was cross-referenced with information available on the CMS Open Payments Database, Dollars for Profs, Google Patents, the United States Patent and Trademark Office (USPTO), and previously published COI disclosures. Results Eight systematic reviews authored by 83 authors were included. Of these authors, 19 (23.0%) were found to have a COI, of which the majority (17/19; 89.5%) had at least one undisclosed COI. Despite nearly one-quarter of authors having a COI, we found no association between the presence of a COI and the favorability of results (P = 0.64) or conclusions (P = 0.07). Conclusions COI are common and frequently undisclosed among systematic review authors investigating opioid analgesics for the management of chronic non-cancer pain. Despite a high prevalence of COI, we did not find that these author-industry relationships had a significant influence on the favorability of results and conclusions; however, our findings should be considered a lower bound estimate of the true influence author COI have on outcomes of pain medicine systematic reviews secondary to the low sample size included in the present study. [ABSTRACT FROM AUTHOR]
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- 2022
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11. Effect of Scheduled Intravenous Acetaminophen in an Enhanced Recovery Protocol Pathway in Patients Undergoing Major Abdominal Procedures: A Prospective, Randomized, and Placebo-Controlled Clinical Trial.
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Subramaniam, Kathirvel, Esper, Stephen A, Mallikarjun, Kushanth, Dickson, Alec, Ruppert, Kristin, Drabek, Tomas, Wong, Hesper, and Holder-Murray, Jennifer
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NARCOTICS , *INTRAVENOUS therapy , *ACADEMIC medical centers , *PAIN measurement , *ACETAMINOPHEN , *ANALGESICS , *POSTOPERATIVE care , *SURGERY , *PATIENTS , *MEDICAL protocols , *RANDOMIZED controlled trials , *PLACEBOS , *PATIENT-controlled analgesia , *DESCRIPTIVE statistics , *STATISTICAL sampling , *POSTOPERATIVE pain ,DIGESTIVE organ surgery - Abstract
Objective Enhanced recovery protocols (ERPs) utilize multi-modal analgesia regimens. Individual regimen components should be evaluated for their analgesic efficacy. We evaluated the effect of scheduled intravenous (IV) acetaminophen within an ERP on analgesia and recovery after a major abdominal surgery. Design This study is a prospective, randomized, double-blinded clinical trial. Setting The study setting was a tertiary care, academic medical center. Subjects Adult patients scheduled for elective major abdominal surgical procedures. Methods Patients in group A received 1 g IV acetaminophen, while patients in group P received IV placebo every six hours for 48 hours postoperatively within an ERP. Pain scores, opioid requirements, nausea and vomiting, time to oral intake and mobilization, length of stay, and patient satisfaction scores were measured and compared. Results From 412 patients screened, 154 patients completed the study (Group A: 76, Group P: 78). Primary outcome was the number of patients with unsatisfactory pain relief, defined as a composite of average Numeric Rating Scale (NRS) scores above 5 and requirement of IV patient-controlled analgesia for pain relief during the first 48 hours postoperatively, and was not significantly different between the two groups (33 (43.4%) in group A versus 42 (53.8%) patients in group P, P = .20). Opioid consumption was comparable between two groups. Group A utilized significantly less postoperative rescue antiemetics compared to group P (41% vs. 58%, P = .02). Conclusions Scheduled administration of IV acetaminophen did not improve postoperative analgesia or characteristics of postoperative recovery in patients undergoing major abdominal surgery within an ERP pathway. [ABSTRACT FROM AUTHOR]
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- 2022
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12. Intraoperative Methadone Use in Cardiac Surgery: A Systematic Review.
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Lobova, Veronika A, Roll, John M, and Roll, Marshall L C
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THERAPEUTIC use of narcotics , *METHADONE treatment programs , *MEDICAL care standards , *CARDIAC surgery , *NARCOTICS , *ONLINE information services , *PAIN measurement , *MEDICAL information storage & retrieval systems , *INFORMATION storage & retrieval systems , *MEDICAL databases , *INTRAOPERATIVE care , *SYSTEMATIC reviews , *ANALGESICS , *THORACIC surgery , *HEART , *FENTANYL , *MORPHINE , *RANDOMIZED controlled trials , *MATHEMATICAL variables , *QUALITY assurance , *MEDLINE , *METHADONE hydrochloride , *POSTOPERATIVE pain - Abstract
Objective To investigate the effects of intraoperative methadone in comparison with those of standard-of-care intraoperative opioids, such as fentanyl and morphine, on pain scores, opioid consumption, and adverse effects in adults undergoing cardiothoracic surgery. Methods The literature was reviewed in PubMed, Embase, Cochrane Library, and Google Scholar, followed by a manual search of the reference lists of the identified articles. Search terms included a combination of "intraoperative methadone," "methadone," and "cardiac surgery." Our review includes four studies published between 2011 and 2020. Quality assessment of the studies was performed. Results The initial search identified 715 articles, from which 461 duplicates were removed and 236 were eliminated on the basis of inclusion and exclusion criteria. Eighteen articles underwent full-text review. Four studies evaluating a total of 435 patients with various cardiothoracic procedures were included in this review. We found that intraoperative methadone decreased acute postoperative pain and reduced postoperative opioid consumption in the first 24 postoperative hours in patients who received 0.1–0.3 mg/kg intraoperative methadone in comparison with morphine and fentanyl. No difference was found in adverse effects between the groups. Quality assessment of the studies showed a low risk of bias in three of the randomized controlled trials and a high risk of bias in the retrospective review because of the baseline confounding bias in the study design. Conclusions Intraoperative methadone use reduces acute postoperative pain and lowers opioid consumption in comparison with morphine and fentanyl. Initial results suggest that methadone may be an equivalent opioid to be administered during cardiothoracic procedures to reduce acute postsurgical pain, though further research is warranted. [ABSTRACT FROM AUTHOR]
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- 2021
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13. Association Between Statewide Opioid Prescribing Interventions and Opioid Prescribing Patterns in North Carolina, 2006–2018.
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Maierhofer, Courtney N, Ranapurwala, Shabbar I, DiPrete, Bethany L, Fulcher, Naoko, Ringwalt, Christopher L, Chelminski, Paul R, Ives, Timothy J, Dasgupta, Nabarun, Go, Vivian F, and Pence, Brian W
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THERAPEUTIC use of narcotics , *HEALTH policy , *NARCOTICS , *ANALGESICS , *STATE governments , *PUBLIC health , *MORPHINE , *DRUG prescribing , *DRUGS , *DRUG monitoring , *EPIDEMICS , *PHYSICIAN practice patterns , *OPIOID abuse - Abstract
Objective To examine the impact of three sequential statewide policy and legislative interventions on opioid prescribing practices among privately insured individuals in North Carolina. Methods An interrupted time series approach was used to examine level and trajectory changes of new and prevalent opioid prescription rates, days' supply, and daily morphine milligram equivalents before and after implementation of a 1) prescription drug monitoring program, 2) state medical board initiative, and 3) legislative action. Analyses were conducted using individual-level claims data from a large private health insurance provider serving North Carolina residents, ages 18–64 years, from January 2006 to August 2018. Results Rates of new and prevalent prescription opioid patients were relatively unaffected by the prescription monitoring program but sharply declined in the months immediately following both medical board (−3.7 new and −19.3 prevalent patients per 10,000 person months) and legislative (−14.1 new and −26.7 prevalent patients) actions. Among all opioid prescriptions, days' supply steadily increased on average over the study period but declined after legislative action (−1.5 days' supply per year). Conclusions The voluntary prescription drug monitoring program launched in 2010 only marginally affected opioid prescribing patterns on its own, but its redeployment as an investigative and clinical tool in multifaceted public policy approaches by the state medical board and legislature later in the decade plausibly contributed to notable declines in prescription rates and days' supply. This study lends new emphasis to the importance of enforcement mechanisms for state and national policies seeking to reverse this critical public health crisis. [ABSTRACT FROM AUTHOR]
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- 2021
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14. Assessing Variation in State Opioid Tapering Laws: Comparing State Laws with the CDC Guideline.
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Danielson, Elizabeth C, Harle, Christopher A, Silverman, Ross, Blackburn, Justin, and Menachemi, Nir
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NARCOTICS , *CHRONIC pain , *DATABASES , *MEDICAL information storage & retrieval systems , *ANALGESICS , *SYSTEMATIC reviews , *DRUG overdose , *STATE governments , *COMPARATIVE studies , *DRUG therapy , *DRUG prescribing , *PHYSICIAN practice patterns , *OPIOID abuse ,FEDERAL government of the United States - Abstract
Objective In 2016, the Center for Disease Control and Prevention released an opioid prescribing guideline for primary care in response to opioid overdose deaths. Despite efforts to encourage safer prescribing practices, experts and federal agencies suspect prescribing guidelines may be misapplied in clinical practice, resulting in abrupt tapering from opioid therapy. Although state laws likely influence prescriber behavior, little is known about state tapering laws. Thus, we examined the scope and variation of state tapering laws compared with federal opioid guidelines. Methods We conducted a comprehensive review of state laws through December 31, 2019, using keyword searches in LexisNexus. Identified laws were coded based on the inclusion of attributes derived from federal opioid guidelines and an expert consensus panel report. We examined whether law attributes were associated with state characteristics, including region, population, governor's political affiliation, opioid prescribing rates, and opioid overdose rates. Results We found 27 states and one federal district had law(s) mentioning tapering. Most laws were authored by medical boards or workers' compensation groups (65.6%) while some laws included a penalty (32.8%). Approximately half of guideline attributes (54.2%) were included in state laws; however, only two state's laws cautioned against abrupt tapering. States with higher overdose death rates were more likely to enact a tapering law (P < 0.001) and have a penalty (P = 0.007). Conclusions State tapering laws incorporate some federal guideline attributes but most lack attributes deemed critical by experts. Without clear instruction, patients risk inappropriate tapering and discontinuation of opioid therapy. Given these findings, policymakers should consider addressing this gap. [ABSTRACT FROM AUTHOR]
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- 2021
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15. Survey of Pain Medicine Specialists' Familiarity with Migraine Management.
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Minen, Mia T, Yang, Jackie, Ashina, Sait, Rosen, Noah, and Duarte, Robert
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MIGRAINE prevention , *NARCOTICS , *MIGRAINE , *INTERNET , *CROSS-sectional method , *ANALGESICS , *SURVEYS , *PHYSIOLOGICAL control systems , *DESCRIPTIVE statistics , *PAIN management , *MEDICAL specialties & specialists , *COGNITIVE therapy - Abstract
Objective Pain specialists treat patients with headache and interface with those who use opioids more so than neurologists and headache specialists. We assessed the headache medicine knowledge and needs of pain specialists. Design/Setting Cross-sectional online survey. Subjects Members of the American Academy of Pain Medicine. Methods Survey was based on a prior survey of primary care providers' knowledge and needs and was iteratively updated by four headache specialists, two with pain medicine affiliations. Results Of the 105 respondents, 71.4% were physicians, 34.3% were women, and they averaged 20.0 ± 13.6 years in practice. The most common specialty was anesthesia (36.1%, n = 35/97) followed by neurology (14.4%, n = 14/97). About half of providers (55.7%, n = 34/61 and 53.3%, n = 32/60) were familiar with the American Academy of Neurology Guidelines for pharmacological migraine prevention and the Choosing Wisely Campaign recommendations for limiting neuroimaging and opioids. Less than half of all providers (39.7%, n = 23/58) were familiar with the American Headache Society guidelines for emergency management of migraine. Providers were aware of Level A evidence-based nonpharmacological therapies, with over three-fourths recognizing cognitive behavioral therapy (80.7%, n = 50/62) and biofeedback (75.8%, n = 47/62) as evidence-based interventions. About 80% of providers (n = 50/64) estimate making migraine diagnoses in ≤50% of their patients with headache. Providers consider starting preventive headache therapy at 7.1 ± 3.9 days/month and report referring 34.3%±34.2% of patients to behavioral interventions. Conclusions Dissemination and implementation of headache guidelines is needed for pain medicine specialists. Providers may need help diagnosing migraine based on currently accepted guidelines and referring for evidence-based behavioral therapies. [ABSTRACT FROM AUTHOR]
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- 2021
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16. Adapting Pain and Opioid Prescribing Continuing Education to the Virtual Environment: Optimizing Program Factors While Navigating Context.
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Sud, Abhimanyu, Harris, Meera, and Hodgson, Katherine
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NARCOTICS , *ANALGESICS , *PROFESSIONAL employee training , *PHYSIOLOGICAL adaptation , *CONTINUING education , *DRUG prescribing , *CLINICAL competence , *PHYSICIAN practice patterns , *PAIN management , *PATIENT safety - Abstract
The article focuses on Safer Opioid Prescribing (SOP) is a well-established Canadian continuing professional development program focused on improving chronic pain care and opioid prescribing practices. Topics include the program, described in detail elsewhere was conceived as an education-focused policy intervention for the Canadian opioid crisis, and the developers and faculty intentionally drew on principles of complex health interventions to inform the design and delivery of the program.
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- 2021
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17. Associations of Pain Numeric Rating Scale Scores Collected during Usual Care with Research Administered Patient Reported Pain Outcomes.
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Nugent, Shannon M, Lovejoy, Travis I, Shull, Sarah, Dobscha, Steven K, and Morasco, Benjamin J
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MUSCULOSKELETAL system diseases , *NARCOTICS , *STATISTICS , *PAIN measurement , *RESEARCH methodology evaluation , *TIME , *FUNCTIONAL status , *HEALTH outcome assessment , *DISABILITY evaluation , *MENTAL health , *CLINICAL medicine research , *PRIMARY health care , *EDUCATIONAL tests & measurements , *REPEATED measures design , *MENTAL depression , *CLINICAL competence , *DATA analysis , *ANXIETY , *ELECTRONIC health records , *MEDICAL research , *SECONDARY analysis , *LONGITUDINAL method , *OUTPATIENT services in hospitals , *EVALUATION - Abstract
Objective The purpose of this study is to examine the extent to which numeric rating scale (NRS) scores collected during usual care are associated with more robust and validated measures of pain, disability, mental health, and health-related quality of life (HRQOL). Design We conducted a secondary analysis of data from a prospective cohort study. Subjects We included 186 patients with musculoskeletal pain who were prescribed long-term opioid therapy. Setting VA Portland Health Care System outpatient clinic. Methods All patients had been screened with the 0–10 NRS during routine outpatient visits. They also completed research visits that assessed pain, mental health and HRQOL every 6 months for 2 years. Accounting for nonindependence of repeated measures data, we examined associations of NRS data obtained from the medical record with scores on standardized measures of pain and its related outcomes. Results NRS scores obtained in clinical practice were moderately associated with pain intensity scores (B's = 0.53–0.59) and modestly associated with pain disability scores (B's = 0.33–0.36) obtained by researchers. Associations between pain NRS scores and validated measures of depression, anxiety, and health related HRQOL were low (B's = 0.09–0.26, with the preponderance of B 's < .20). Conclusions Standardized assessments of pain during usual care are moderately associated with research-administered measures of pain intensity and would be improved from the inclusion of more robust measures of pain-related function, mental health, and HRQOL. [ABSTRACT FROM AUTHOR]
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- 2021
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18. Beliefs About Perioperative Opioid and Alcohol Use among Elective Surgical Patients Who Report Unhealthy Drinking: A Qualitative Study.
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Fernandez, Anne C, Lin, Lewei A, Bazzi, Angela R, Boissoneault, Jeff, Borsari, Brian, and Blow, Frederic
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NARCOTICS , *ELECTIVE surgery , *PERIOPERATIVE care , *ALCOHOLISM , *ACADEMIC medical centers , *RESEARCH methodology , *SURGERY , *PATIENTS , *INTERVIEWING , *QUALITATIVE research , *HEALTH attitudes , *ALCOHOL drinking , *THEMATIC analysis , *PAIN management - Abstract
Objectives Elective surgical patients with unhealthy alcohol use have unique pain management needs and addiction risk factors that are relevant to surgical preparation and recovery. This descriptive qualitative study sought to better understand patients' beliefs and behaviors related to opioid use, alcohol use, and pain management in the perioperative context. Design We conducted individual semi-structured interviews between July 2017 and March 2018. Setting A large Midwestern academic health system. Subjects Participants were elective surgical patients meeting unhealthy alcohol use criteria, recruited from the health system's preoperative anesthesia clinic. Method Semistructured interview guides explored beliefs and behaviors relating to alcohol and opioid use, health status, and surgical care. Interview recordings were transcribed and coded for thematic analysis. Results Among 20 elective surgical patients (25% female), we identified three key themes regarding alcohol use, opioid use, and their co-use before and after surgery. First, desires and intentions to use opioids for postoperative pain management varied widely, even before opioids were prescribed. Second, some participants described alcohol as a preferred pain management strategy. Third, participants held a range of beliefs about the risks and benefits of alcohol and opioid co-use. Conclusions Appropriate assessment of beliefs and intentions regarding opioid and alcohol use could help identify patients most vulnerable to new opioid problems and unhealthy alcohol use in the context of perioperative surgical pain. These findings have important implications for perioperative pain management. [ABSTRACT FROM AUTHOR]
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- 2021
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19. Veterans' Experiences of an Opioid Specialty Clinic.
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Sowicz, Timothy Joseph and Hausmann, Leslie R M
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THERAPEUTIC use of narcotics , *CHRONIC pain , *NARCOTICS , *HEALTH facilities , *ACADEMIC medical centers , *ANALGESICS , *RESEARCH methodology , *INTERVIEWING , *PSYCHOLOGY of veterans , *EXPERIENCE , *HEALTH literacy , *QUALITATIVE research , *HEALTH attitudes , *DESCRIPTIVE statistics , *DRUG prescribing , *ELECTRONIC health records , *CONTENT analysis , *PHYSICIAN practice patterns , *MEDICAL specialties & specialists , *PATIENT safety - Abstract
Objective Opioid specialty clinics have emerged as an approach for mitigating the risks associated with opioid therapies. Many opioid specialty clinics within the Department of Veterans Affairs (VA) have been described in the extant literature, yet veterans' experiences of these remain absent. This research study was undertaken to describe veterans' responses (e.g. knowledge, attitudes, and beliefs) toward being evaluated in an opioid specialty clinic. Design Qualitative descriptive research study. Setting A VA medical center in the northeast United States. Subjects Twenty veterans were interviewed between December 2017 and May 2018. Methods Veterans' characteristics were extracted from the VA's electronic health record and analyzed with descriptive statistics. Qualitative data about veterans' experiences with the opioid specialty clinic were collected via semistructured interviews (in person or via telephone) and were analyzed with qualitative content analysis. Results Most participants were older, non-Hispanic or non-Latino white men. Generally, veterans had positive experiences in the opioid specialty clinic. However, there was wide variation in their understanding of the purpose of the clinic, who staffed the clinic, and why they had been referred to the clinic. Conclusions For veterans prescribed opioid therapies, this clinic served as an adjunct service for ensuring appropriate and safe prescribing. Data from this study can be used to inform interventions to promote veterans' understanding across the total opioid safety clinic experience—referral, actual visit, and follow-up. [ABSTRACT FROM AUTHOR]
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- 2021
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20. Clearing up the Confusion: What to Do with Ethanol and Ethanol Metabolites in Urine Drug Screens.
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Smith, Michael D, Emerick, Trent, Brancolini, Scott, and Alter, Benedict
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NARCOTICS , *BIOMARKERS , *CODEINE , *ANALGESICS , *DRUG use testing , *ALCOHOL drinking , *DRUG prescribing , *ETHANOL , *URINALYSIS , *DECISION making in clinical medicine , *MEDICAL prescriptions , *PHYSICIAN practice patterns , *METABOLITES - Abstract
The article focuses on increased rate of opioid medication prescribing, use of high potency opioids such as oxycodone and fentanyl, and an increasing number of patients receiving long-term opioid therapy have been documented as contributing factors in the opioid epidemic. Topics include the alcohol misuse and use disorder have been associated with considerable morbidity and mortality, and the mitigate the increasing rates of opioid-related deaths and to elucidate aberrant drugrelated behaviors.
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- 2021
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21. Opioid Prescribing After Implementation of Single Click Access to a State Prescription Drug Monitoring Program Database in a Health System's Electronic Health Record.
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Weiner, Scott G, Kobayashi, Kimiyoshi, Reynolds, Joshua, Chan, Kit, Kelly, Rodd, Wakeman, Sarah, Reddy, Prabashni, and Young, Leonard D
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NARCOTICS , *DATABASES , *MEDICAL information storage & retrieval systems , *ANALGESICS , *PUBLIC health , *COMPARATIVE studies , *PRE-tests & post-tests , *DRUG prescribing , *DRUG monitoring , *DESCRIPTIVE statistics , *PHYSICIAN practice patterns , *ELECTRONIC health records - Abstract
Objectives To determine the effect of one-click integration of a state's prescription drug monitoring program (PDMP) on the number of PDMP searches and opioid prescriptions, stratified by specialty. Methods Our large health system worked with the state department of public health to integrate the PDMP with the electronic health record (EHR), which enabled providers to query the data with a single click inside the EHR environment. We evaluated Schedule II or III opioid prescriptions reported to the Massachusetts PDMP 6 months before (November 15, 2017-May 15, 2018) and 6 months after (May 16, 2018, to November 16, 2018) integration. Search counts, prescriptions, patients, morphine milligram equivalents, as well as prescriber specialty were compared. Results There were 3,185 unique prescribers with a record of a Schedule II and/or III opioid prescription in both study periods that met inclusion criteria. After integration, the number of PDMP searches increased from 208,684 in the pre-integration phase to 298,478 searches in the post-integration phase (+43.0%). The number of opioid prescriptions dispensed decreased by 4.8%, the number of patients receiving a prescription decreased by 5.1%, and the mean morphine milligram equivalents (MMEs) per prescriber decreased by 5.4%. There were some notable specialty-specific differences in these measures. Conclusions Integration of the PDMP into the EHR markedly increased the number of searches but was associated with modest decreases in opioids prescribed and patients receiving a prescription. Single click EHR integration of the PDMP, if implemented broadly, may be a way for states to significantly increase PDMP utilization. [ABSTRACT FROM AUTHOR]
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- 2021
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22. Opioid Overdose Risk in Patients Returning to the Emergency Department for Pain.
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Sheikh, Sophia, Booth-Norse, Ashley, Holden, David, Henson, Morgan, Dodd, Caroline, Edgerton, Eric, James, Divya, Kalynych, Colleen, Smotherman, Carmen, and Hendry, Phyllis
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NARCOTICS , *CHRONIC pain , *STATISTICS , *SUBSTANCE abuse , *HOSPITAL emergency services , *SCIENTIFIC observation , *ACQUISITION of data methodology , *ANALGESICS , *INTERVIEWING , *MANN Whitney U Test , *FISHER exact test , *RACE , *RISK assessment , *MEDICAL records , *DESCRIPTIVE statistics , *DATA analysis , *PAIN management , *SECONDARY analysis , *LONGITUDINAL method ,DRUG overdose risk factors - Abstract
Objective Using the Risk Index for Overdose or Serious Opioid-induced Respiratory Depression (CIP-RIOSORD) in patients returning to the emergency department (ED) for pain and discharged with an opioid prescription, we assessed overall opioid overdose risk and compared risk in opioid naive patients to those who are non-opioid naive. Design This was a secondary analysis from a prospective observational study of patients ≥ 18 years old returning to the ED within 30 days. Data were collected from patient interviews and chart reviews. Patients were categorized as Group 1 (not using prescription opioids) or Group 2 (consuming prescription opioids). Statistical analyses were performed using Fisher's exact and Wilcoxon's rank sum tests. Risk class and probability of overdose was determined using Risk Index for Overdose or Serious Opioid-induced Respiratory Depression (CIP-RIOSORD). Results Of the 389 enrollees who returned to the ED due to pain within 30 days of an initial visit, 67 (17%) were prescribed opioids. The majority of these patients were in Group 1 (60%). Both Group 1 (n = 40) and Group 2 (n = 27) held an average CIP-RIOSORD risk class of 3. Race significantly differed between groups; the majority of Group 1 self-identified as African American (80%) (P = .0267). There were no differences in age, gender, or CIP-RIOSORD risk class between groups. However, Group 2 had nearly double the number of predictive factors (median = 1.93) as Group 1 (median = 1.18) (P = .0267). Conclusions A substantial proportion of patients (25%) were high risk for opioid overdose. CIP-RIOSORD may prove beneficial in risk stratification of patients discharged with prescription opioids from the ED. [ABSTRACT FROM AUTHOR]
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- 2021
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23. Reward Responsiveness in Patients with Opioid Use Disorder on Opioid Agonist Treatment: Role of Comorbid Chronic Pain.
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Finan, Patrick H, Letzen, Janelle, Epstein, David H, Mun, Chung Jung, Stull, Samuel, Kowalczyk, William J, Agage, Daniel, Phillips, Karran A, Pizzagalli, Diego A, and Preston, Kenzie L
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CHRONIC pain treatment , *NARCOTICS , *SUBSTANCE abuse , *CONFIDENCE intervals , *COMPARATIVE studies , *DESCRIPTIVE statistics - Abstract
Objective Evidence suggests that blunted reward responsiveness may account for poor clinical outcomes in both opioid use disorder (OUD) and chronic pain. Understanding how individuals with OUD and comorbid chronic pain (OUD+CP) respond to rewards is, therefore, of clinical interest because it may reveal a potential point of behavioral intervention. Methods Patients with OUD (n = 28) and OUD+CP (n = 19) on opioid agonist treatment were compared on: 1) the Probabilistic Reward Task (an objective behavioral measure of reward response bias) and 2) ecological momentary assessment of affective responses to pleasurable events. Results Both the OUD and the OUD+CP groups evidenced an increase in reward response bias in the Probabilistic Reward Task. The rate of change in response bias across blocks was statistically significant in the OUD group (B = 0.06, standard error [SE] = 0.02, t = 3.92, P < 0.001, 95% confidence interval [CI]: 0.03 to 0.09) but not in the OUD+CP group (B = 0.03, SE = 0.02, t = 1.90, P = 0.07, 95% CI: −0.002 to 0.07). However, groups did not significantly differ in the rate of change in response bias across blocks (B = 0.03, SE = 0.02, t = 1.21, P = 0.23, 95% CI: −0.02 to 0.07). Groups did not significantly differ on state measures of reward responsiveness (P' s ≥0.50). Conclusions Overall, findings across objective and subjective measures were mixed, necessitating follow-up with a larger sample. The results suggest that although there is a reward response bias in patients with OUD+CP treated with opioid agonist treatment relative to patients with OUD without CP, it is modest and does not appear to translate into patients' responses to rewarding events as they unfold in daily life. [ABSTRACT FROM AUTHOR]
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- 2021
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24. Evaluation of the Relationship Between Geographic Proximity and Treatment for People Referred to a Metropolitan Multidisciplinary Pain Clinic.
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Giummarra, Melita J, Arnold, Carolyn A, and Beck, Ben Ben
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OBESITY , *NARCOTICS , *HEALTH services accessibility , *SCIENTIFIC observation , *UNEMPLOYMENT , *TRAVEL , *CROSS-sectional method , *POPULATION geography , *PAIN clinics , *MEDICAL referrals , *HEALTH care teams , *DESCRIPTIVE statistics , *MEDICAL appointments , *ODDS ratio , *DATA analysis software , *PAIN management - Abstract
Objective This study examined which patient characteristics are associated with traveling further to attend a metropolitan, publicly funded pain management service, and whether travel distance was associated with differences in treatment profile, duration, and percentage of appointments attended. Design Cross-sectional observational cohort study. Method Patients ≤70 years of age with a single referral between January 2014 and June 2018 who had not died within 12 months of their first appointment and who had a usual place of residence were included (N = 1,684; mean age = 47.2 years; 55.5% female). Travel distance was calculated with the HERE Routing API on the basis of historical travel times for each scheduled appointment. Results Median travel time was 27.5 minutes (Q1, Q3: 12.5, 46.2). Ordinal regression showed that women had 20% lower odds of traveling further, but people who were overweight or obese (odds ratio [OR] = 1.4–2.3), unemployed (OR = 1.27), or taking higher opioid dosages (OR = 1.79–2.82) had higher odds of traveling further. People traveling >60 minutes had fewer treatment minutes (median = 143 minutes) than people living within 15 minutes of the pain clinic (median = 440 minutes), and a smaller proportion of those traveling >60 minutes attended group programs vs. medical appointments only (n = 35, 17.0%) relative to those living within 15 minutes of their destination (n = 184, 32.6%). People living 16–30 minutes from the clinic missed the highest proportion of appointments. Conclusions Although people traveling further for treatment may be seeking predominantly medical treatment, particularly opioid medications, the present findings highlight the need to further explore patient triage and program models of care to ensure that people living with persistent disabling pain can access the same level of care, regardless of where they live. [ABSTRACT FROM AUTHOR]
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- 2021
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25. Integrated Psychosocial Group Treatment: A Randomized Pilot Trial of a Harm Reduction and Preventive Approach for Patients with Chronic Pain at Risk of Opioid Misuse.
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Hruschak, Valerie, Rosen, Daniel, Tierney, Megan, Eack, Shaun M, Wasan, Ajay D, and Cochran, Gerald
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CHRONIC pain treatment , *NARCOTICS , *PILOT projects , *MINDFULNESS , *AFFINITY groups , *SOCIAL support , *PAIN measurement , *CONFIDENCE intervals , *MOTIVATIONAL interviewing , *MULTIVARIATE analysis , *TREATMENT duration , *PSYCHOEDUCATION , *HARM reduction , *PREVENTIVE health services , *MEDICAL care use , *RANDOMIZED controlled trials , *TREATMENT effectiveness , *BLIND experiment , *DESCRIPTIVE statistics , *INTEGRATED health care delivery , *GROUP psychotherapy , *PAIN management , *OUTPATIENT services in hospitals , *COGNITIVE therapy - Abstract
Objective To examine the benefits of an integrated psychosocial group treatment (IPGT) model for patients with chronic pain at risk of opioid misuse. Design This study was a small-scale, single-blinded, two-group randomized controlled trial. Setting Outpatient. Subjects Adults with chronic pain of >3 months' duration who were currently prescribed opioid medication and were at risk of opioid misuse. Methods Patients with chronic pain who were at risk of opioid misuse (n = 30) were randomly assigned to IPGT or treatment as usual. IPGT consists of six group sessions of psychoeducation, motivational interviewing, cognitive behavioral therapy, mindfulness, and peer support. Participants were assessed at baseline, first follow-up at 6 weeks, and a posttreatment follow-up at 9 weeks. Outcomes included feasibility, acceptability, and preliminary efficacy. Data were analyzed with descriptive and multivariate analyses. Results All intervention components were delivered to 87% of the participants, and IPGT recipients reported a high level of satisfaction. Results of the multivariate analyses demonstrated nonsignificant improvements in pain severity (β = 0.22, 95% CI: –0.24 to 0.66, P = 0.35). However, we observed significant treatment × time interactions on pain interference (β = 3.32, 95% confidence interval [CI]: 0.01 to 6.65, P = 0.05) and pain catastrophizing (β = 2.74, 95% CI: 0.49 to 4.99, P = 0.02). Lastly, we detected no significant differences in opioid misuse (adjusted odds ratio = 0.69, 95% CI: –0.26 to 1.64, P = 0.16). Conclusion This study provides support for the IPGT intervention being acceptable and feasible for delivery in patients with chronic pain at risk of opioid misuse. Efficacy was achieved in pain interference and pain catastrophizing. [ABSTRACT FROM AUTHOR]
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- 2021
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26. Long-Term Results with Adjuvant Ozone Therapy in the Management of Chronic Pelvic Pain Secondary to Cancer Treatment.
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Clavo, Bernardino, Navarro, Minerva, Federico, Mario, Borrelli, Emma, Jorge, Ignacio J, Ribeiro, Ivone, Rodríguez-Melcon, Juan I, Caramés, Miguel A, Santana-Rodríguez, Norberto, and Rodríguez-Esparragón, Francisco
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CHRONIC pain treatment , *PELVIC pain treatment , *CANCER pain treatment , *NARCOTICS , *CANCER chemotherapy , *NEURALGIA , *ANALGESICS , *OZONE therapy , *PAIN management ,PELVIC tumors - Abstract
The article presents Long-Term Results with Adjuvant Ozone Therapy in the Management of Chronic Pelvic Pain Secondary to Cancer Treatment. Topics discussed include Management of local pain after pelvic tumor treatment requires excluding the possibility of tumor relapse and, at the same time, starting analgesic and opioid treatment as needed; and patients with potentially prolonged life expectancy, high doses of opioids are controversial because their long-term safety and effectiveness.
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- 2021
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27. Persistent Post-Mastectomy Pain: The Impact of Regional Anesthesia Among Patients with High vs Low Baseline Catastrophizing.
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Zinboonyahgoon, Nantthasorn, Patton, Megan E, Chen, Yun-Yun K, Edwards, Rob R, and Schreiber, Kristin L
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NARCOTICS , *PAIN measurement , *SCIENTIFIC observation , *ANALGESICS , *REGRESSION analysis , *MASTECTOMY , *PAIN catastrophizing , *POSTOPERATIVE pain , *CONDUCTION anesthesia , *LONGITUDINAL method - Abstract
Background Persistent post-mastectomy pain (PPMP) varies both in its severity and impact, with psychosocial factors such as catastrophizing conferring greater risk. Preoperative regional anesthesia (RA) is an important nonopioid therapy, but with variable success at preventing PPMP in previous reports. We previously reported that RA was associated with lower acute post-mastectomy pain and opioid use, but more prominently among patients with higher baseline catastrophizing. The current longitudinal investigation at 3, 6, and 12 months postop aimed to detect differential long-term impact of RA on PPMP among patients with high vs low catastrophizing. Methods In this prospective observational study, patients (n = 123) completed preoperative psychosocial assessment and underwent mastectomy either with (n = 56) or without (n = 67) preoperative RA. Generalized estimating equation (GEE) regression analysis assessed impact of baseline catastrophizing, RA, and their interaction, on the primary outcome of pain severity index, as well as secondary outcomes including cognitive and emotional impact of pain, and persistent opioid use. Results We observed a significant interaction between the effect of catastrophizing and RA on PPMP. Specifically, RA was associated with reduced pain severity and pain impact 3, 6, and 12 months postoperatively, but only among those with high baseline catastrophizing scores. In addition, both RA and lower catastrophizing scores were associated with lower incidence of persistent opioid use. Conclusions The efficacy of therapies to prevent PPMP may be importantly influenced by pain-modulatory psychosocial characteristics. These findings underscore the importance of considering individual patient factors when applying preventive treatments, and of including their assessment in future trials. [ABSTRACT FROM AUTHOR]
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- 2021
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28. Pain Experiences of Adults With Sickle Cell Disease and Hematopoietic Stem Cell Transplantation: A Qualitative Study.
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Hamayel, Nebras Abu Al, Waldfogel, Julie M, Hannum, Susan M, Brodsky, Robert A, Bolaños-Meade, Javier, Gamper, Christopher J, Jones, Richard J, and Dy, Sydney M
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THERAPEUTIC use of narcotics , *NARCOTICS , *THERAPEUTICS , *PAIN , *ANALGESICS , *SURGERY , *PATIENTS , *INTERVIEWING , *PATIENT-centered care , *HEALTH status indicators , *SOCIAL stigma , *EXPERIENCE , *PATIENTS' attitudes , *QUALITATIVE research , *COMPARATIVE studies , *QUALITY of life , *HEMATOPOIETIC stem cell transplantation , *THEMATIC analysis , *DECISION making in clinical medicine , *SICKLE cell anemia , *PAIN management , *ADULTS - Abstract
Objective Despite increasing use of hematopoietic stem cell transplantation (HSCT) for adults with sickle cell disease (SCD), little is known about pain management experiences throughout this process. The objective of this study was to explore patients' experiences with pain and pain management during and after HSCT for SCD. Methods We conducted a qualitative interview study with 10 patients who underwent HSCT for SCD. We transcribed interviews verbatim and inductively identified codes. We used thematic analysis alongside a constant comparative method to develop and refine a codebook that aided in the identification of themes. Results Four key themes emerged. (1) The pain trajectory : patients described a fluctuating course of pain during HSCT, which often extended long afterwards and impacted all aspects of life, particularly affected by pre-HSCT experiences; (2) The role of opioids—a double-edged sword : patients described opioids as reducing pain but insufficiently to balance significant adverse effects and burden; (3) Patient-centered decision making in pain management : patients described insufficient agency in decisions about opioid use and weaning; and (4) Consequences of health-related stigma : patients described experiences with stigma, mainly related to opioid use and weaning, as similar to pre-HSCT. Conclusions From the perspective of patients who have undergone HSCT for SCD, clinicians should use a patient-centered approach, integrating non-opioid approaches into pain management, particularly psychosocial support. As transplant for SCD becomes increasingly available, incorporating patient perspectives may improve health care delivery and overall patient experiences. [ABSTRACT FROM AUTHOR]
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- 2021
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29. Customizing CAT Administration of the PROMIS Misuse of Prescription Pain Medication Item Bank for Patients with Chronic Pain.
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You, Dokyoung S, Cook, Karon F, Domingue, Benjamin W, Ziadni, Maisa S, Hah, Jennifer M, Darnall, Beth D, and Mackey, Sean C
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COMPUTER adaptive testing , *CHRONIC pain , *NARCOTICS , *SUBSTANCE abuse , *RESEARCH methodology evaluation , *PSYCHOMETRICS , *QUESTIONNAIRES , *DESCRIPTIVE statistics , *MEDICAL prescriptions , *ANXIETY , *PAIN management - Abstract
Objective The 22-item PROMIS®-Rx Pain Medication Misuse item bank (Bank-22) imposes a high response burden. This study aimed to characterize the performance of the Bank-22 in a computer adaptive testing (CAT) setting based on varied stopping rules. Methods The 22 items were administered to 288 patients. We performed a CAT simulation using default stopping rules (CATPROMIS). In 5 other simulations, a "best health" response rule was added to decrease response burden. This rule stopped CAT administration when a participant selected "never" to a specified number of initial Bank-22 items (2–6 in this study, designated CATAlt2-Alt6). The Bank-22 and 7-item short form (SF-7) scores were compared to scores based on CATPROMIS, and the 5 CAT variations. Results Bank-22 scores correlated highly with the SF-7 and CATPROMIS, Alt5, Alt6 scores (r =0.87–0.95) and moderately with CATAlt2- Alt4 scores (r =0.63–0.74). In all CAT conditions, the greatest differences with Bank-22 scores were at the lower end of misuse T-scores. The smallest differences with Bank-22 and CATPROMIS scores were observed with CATAlt5 and CATAlt6. Compared to the SF-7, CATAlt5 and CATAlt6 reduced overall response burden by about 42%. Finally, the correlations between PROMIS-Rx Misuse and Anxiety T-scores remained relatively unchanged across the conditions (r =0.31–0.43, Ps <.001). Conclusions Applying a stopping rule based on number of initial "best health" responses reduced response burden for respondents with lower levels of misuse. The tradeoff was less measurement precision for those individuals, which could be an acceptable tradeoff when the chief concern is in discriminating higher levels of misuse. [ABSTRACT FROM AUTHOR]
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- 2021
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30. Opioid Tapering/Detoxification Protocols, A Compendium: Narrative Review.
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Fishbain, David A
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NARCOTICS , *CHRONIC pain , *ANALGESICS , *MEDICAL protocols , *DRUG therapy , *EPIDEMICS , *OPIOID abuse - Abstract
Objectives The opioid epidemic has put pressure on clinicians to taper their chronic pain patients (CPPs) from opioids. This has resulted in rapid or forced tapers and opioid discontinuation. Partially responsible is lack of information on how to taper (tapering protocols).The objectives of this narrative review were then the following: compile all the published opioid tapering/detoxification protocols from the pain/drug rehabilitation/psychiatric literature whether for inpatient or outpatient use; organize these into general types; compare the types for advantages/disadvantages for use by a clinician in an outpatient setting; and answer some commonly asked questions relating to opioid tapering. Methods Relevant references were identified by a search strategy utilizing the terms tapering, tapering protocols, detoxification, detoxification protocols, withdrawal, dependence, addiction, and drug rehabilitation. These were explored with the term opioids. Identified abstract were reviewed for any study relating to the objectives of this review. Those studies were then included in this review. As this is a narrative review, no quality ratings of these references were performed. Results Of 1,922 abstracts identified by this search strategy, 301 were reviewed in detail for potential inclusion. Of these, 104 were utilized in this review. Nine types of opioid tapering protocols were identified and compared in tabular form. Twenty-two questions in reference to opioid tapering were addressed. Conclusions Based on this review, the protocol utilizing the opioid of current use is the simplest to use as it requires no rotation to another opioid and thereby avoids rotation errors. It also has behavior advantages. [ABSTRACT FROM AUTHOR]
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- 2021
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31. Longitudinal Dose Trajectory Among Patients Tapering Long-Term Opioids.
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Fenton, Joshua J, Magnan, Elizabeth M, Agnoli, Alicia L, Henry, Stephen G, Xing, Guibo, and Tancredi, Daniel J
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NARCOTICS , *ANALGESICS , *RETROSPECTIVE studies , *REGRESSION analysis , *LONGITUDINAL method - Abstract
Objective To evaluate the dose trajectory of new opioid tapers and estimate the percentage of patients with sustained tapers at long-term follow-up. Design Retrospective cohort study. Setting Data from the OptumLabs Data Warehouse® which includes de-identified medical and pharmacy claims and enrollment records for commercial and Medicare Advantage enrollees, representing a diverse mixture of ages, ethnicities, and geographical regions across the United States. Subjects Patients prescribed stable, higher-dose opioids for ≥12 months from 2008 to 2018. Methods Tapering was defined as ≥15% relative reduction in average MME/day during any of six overlapping 60-day periods in the initial 7 months of follow-up after the period of stable baseline dosing. Average monthly dose was ascertained during consecutive 60-day periods up to 16 months of follow-up. Linear regression estimated the geometric mean relative dose by tapering status and follow-up duration. Poisson regression estimated the percentage of tapered patients with sustained dose reductions at follow-up and patient-level predictors of failing to sustain tapers. Results The sample included 113,618 patients with 203,920 periods of stable baseline dosing (mean follow-up = 13.7 months). Tapering was initiated during 37,170 follow-up periods (18.2%). After taper initiation, patients had a substantial initial mean dose reduction (geometric mean relative dose.73 [95% CI:.72–.74]) that was sustained through 16 months of follow-up; at which point, 69.8% (95% CI: 69.1%–70.4%) of patients who initiated tapers had a relative dose reduction ≥15%, and 14.2% (95% CI: 13.7%–14.7%) had discontinued opioids. Failure to sustain tapers was significantly less likely among patients with overdose events during follow-up (adjusted incidence rate ratio [aIRR]:.56 [95% CI:.48–.67]) and during more recent years (aIRR:.93 per year after 2008 [95% CI:.92–.94]). Conclusions In an insured and Medicare Advantage population, over two-thirds of patients who initiated opioid dose tapering sustained long-term dose reductions, and the likelihood of sustaining tapers increased substantially from 2008 to 2018. [ABSTRACT FROM AUTHOR]
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- 2021
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32. Patient and Provider Acceptability of a Patient Preauthorized Concealed Opioid Reduction.
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Bedford, Theresa, Adediran, Timileyin, Haycock, Nathaniel R, Mullins, C Daniel, Medeiros, Michelle, Wright, Thelma, Curatolo, Michele, Hamlin, Lynette, and Colloca, Luana
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NARCOTICS , *CHRONIC pain , *ANALGESICS , *ATTITUDE (Psychology) , *CROSS-sectional method , *MEDICAL personnel , *PATIENTS' attitudes , *DRUG therapy , *QUESTIONNAIRES - Abstract
Objective Limited research of how to best taper opioids brings about an ethical and clinical dilemma. Experiments using overt and concealed administration of opioids have demonstrated the benefits of a concealed reduction to eliminate negative expectations and prolong analgesic benefits. This may allow for opioid tapering without significant increases in pain. Based on this, we investigated patient and provider acceptance of a concealed opioid reduction for chronic pain. Methods We conducted a cross-sectional survey via REDcap with 74 patients, who are currently taking or have taken high dose opioids, and 49 providers using a validated questionnaire based on two hypothetical clinical trials comparing a patient preauthorized concealed opioid reduction vs standard tapering. Results We found that patients and providers have positive attitudes toward a concealed reduction of opioid dosages. More than 60% of providers and patients surveyed viewed the hypothetical clinical trial as helpful to reduce pain, side effects, and withdrawal symptoms. Sixty-one percent of patients and 77.6% of providers recognized that there would be differences in pain relief depending upon which group the hypothetical participants would be enrolled in. Conclusions Patients and providers appear to understand the benefits of a concealed opioid reduction. Our findings support future randomized controlled trials that compare concealed and overt opioid tapering in patients with chronic pain. More research is needed to understand the difference in attitudes between research and clinical practice and to test the acceptability of a concealed reduction following a participation in an active clinical trial. [ABSTRACT FROM AUTHOR]
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- 2021
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33. Primary Care and Mental Health Prescribers, Key Clinical Leaders, and Clinical Pharmacist Specialists' Perspectives on Opioids and Benzodiazepines.
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Hawkins, Eric J, Lott, Aline M, Danner, Anissa N, Malte, Carol A, Hagedorn, Hildi J, Berger, Douglas, Donovan, Lucas M, Sayre, George G, Mariano, Anthony J, and Saxon, Andrew J
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NARCOTICS , *ATTITUDES of medical personnel , *RESEARCH methodology , *MENTAL health , *DEPRESCRIBING , *INTERVIEWING , *PRIMARY health care , *PHARMACISTS , *BENZODIAZEPINES , *QUALITATIVE research , *SELF-efficacy , *DRUG prescribing , *HEALTH care teams , *MEDICAL prescriptions , *PHYSICIAN practice patterns , *THEMATIC analysis , *TRANQUILIZING drugs - Abstract
Objective Due to increased risks of overdose fatalities and injuries associated with coprescription of opioids and benzodiazepines, healthcare systems have prioritized deprescribing this combination. Although prior work has examined providers' perspectives on deprescribing each medication separately, perspectives on deprescribing patients with combined use is unclear. We examined providers' perspectives on coprescribed opioids and benzodiazepines and identified barriers and facilitators to deprescribing. Design Qualitative study using semistructured interviews. Setting One multisite Veterans Affairs (VA) healthcare system in the United States of America. Subjects Primary care and mental health prescribers, key clinical leaders, clinical pharmacist specialists (N = 39). Methods Interviews were audio-recorded, transcribed, and analyzed using thematic analysis. Themes were identified iteratively, through a multidisciplinary team-based process. Results Analyses identified four themes related to barriers and facilitators to deprescribing: inertia, prescriber self-efficacy, feasibility of deprescribing/tapering, and promoting deprescribing, as well as a fifth theme, consequences of deprescribing. Results highlighted the complexity of deprescribing when multiple prescribers are involved, a need for additional support and time, and concerns about patients' reluctance to discontinue these medications. Facilitators included agreement with the goal of deprescribing and fear of negative consequences if medications are continued. Providers spoke to how deprescribing efforts impaired patient-provider relationships and informed their decisions not to start patients on these medications. Conclusions Although providers agree with the goal, prescribers' belief in a limited deprescribing role, challenges with coordination among prescribers, concerns about insufficient time and patients' resistance to discontinuing these medications need to be addressed for efforts to be successful. [ABSTRACT FROM AUTHOR]
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- 2021
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34. Factors Related to Prescription Drug Monitoring Program Queries for Veterans Receiving Long-Term Opioid Therapy.
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Andrea, Sarah B, Gilbert, Tess A, Morasco, Benjamin J, Saha, Somnath, and Carlson, Kathleen F
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NARCOTICS , *CONFIDENCE intervals , *CLINICAL drug trials , *ANALGESICS , *HUMAN services programs , *MORPHINE , *DRUGS , *DRUG monitoring , *ELECTRONIC health records , *METHADONE hydrochloride , *DRUG development , *MEDICAL care of veterans , *POISSON distribution - Abstract
Objective State prescription drug monitoring programs (PDMPs) identify controlled medications dispensed across providers and systems. Department of Veterans Affairs (VA) policy requires electronic health record documentation of PDMP queries at least annually for VA patients receiving controlled medications; however, queries are not uniformly conducted. We examined factors associated with PDMP queries for veterans receiving long-term opioid therapy. Methods Veterans with a VA provider who received long-term opioid therapy between August 2015 and August 2016 within a four-state region were identified; 9,879 were due for a PDMP query between August 2016 and February 2017. Likelihood of veterans' PDMP queries during this follow-up period was modeled as a function of patient, provider, and facility characteristics of interest in mixed-effects modified Poisson models estimating relative risk and 95% confidence intervals. Multivariable models controlled for potential confounders identified through the use of directed acyclic graphs. Results PDMP queries were documented for 62.1% of veterans that were due for a PDMP query. Veterans were more likely to be queried if they were Hispanic or if they received methadone, had average daily milligram morphine equivalents >20, or received urine drug screening during the studied period. Veterans were less likely to be queried if they had a rural address, mail order medication, or cancer diagnosis. Likelihood of PDMP queries was also lower for veterans whose opioid-prescribing provider was an oncologist or working in a low-complexity facility. Conclusions Adherence to PDMP query policy within the VA varied by patient, clinician, and facility factors. Mechanisms to standardize the conduct of PDMP queries may be needed. [ABSTRACT FROM AUTHOR]
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- 2021
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35. Industry Payments to Pain Medicine Physicians: An Analysis of the Centers for Medicare and Medicaid Services Open Payments Program.
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Goel, Vasudha, Patwardhan, Amol M, Ibrahim, Mohab, Yang, Yan, Sivanesan, Eellan, Banik, Ratan K, Shannon, Clarence, and Shankar, Hariharan
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PHYSICIANS , *NARCOTICS , *PAIN , *ANALGESICS , *RETROSPECTIVE studies , *CONFLICT of interests , *WAGES , *PHYSICIAN practice patterns , *LONGITUDINAL method - Abstract
Objective To analyze industry payments to pain medicine physicians in the United States. Design Retrospective cohort study using publicly available databases. Subjects The study includes U.S. pain medicine physicians (PMPs) with reports in the Open Payments program from 2013 to 2018. Methods The Centers for Medicare and Medicaid Services Open Payments program was analyzed for general, investment, and ownership payments to PMPs reported from 2013 to 2018. The nature, type, and geographic variation of payments were analyzed. Results The main findings of the study are as follows: 1) Payments made to PMPs constituted a small proportion of the payments made to all physicians in the United States, and the number of transactions and the total dollar amount seem to have decreased from 2016 to 2018. 2) The median number of payments among physicians with reported payments was around 4 (interquartile range: 18), and the majority of them were under $20. 3) The majority of payments were for in-kind items and services (85%) and were made for food and beverages (91%), travel and lodging (5.5%). 4) Some of the ownership and investment interest payments exceeded $500,000. 5) The top five drugs associated with physician payments included medications with opioids. 6) A very small minority of payments were made for entertainment or gifts. 7) A third of PMPs with reports had payments reported under more than one taxonomy. Conclusions Overall payments made to PMPs seem to be decreasing since 2016. The majority of the payments are made for the food, beverage, and travel categories. Public and physician awareness of the Open Payments system reports is essential to promote transparency and to minimize adverse effects of financial relationships on patient care. [ABSTRACT FROM AUTHOR]
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- 2021
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36. Impact of Current Pain Status on Low-Barrier Buprenorphine Treatment Response Among Patients with Opioid Use Disorder.
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Peck, Kelly R, Ochalek, Taylor A, Streck, Joanna M, Badger, Gary J, and Sigmon, Stacey C
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CHRONIC pain , *NARCOTICS , *DRUG delivery systems , *SUBSTANCE abuse , *BUPRENORPHINE , *TREATMENT effectiveness , *PSYCHOLOGICAL tests , *DRUG monitoring , *BRIEF Pain Inventory , *QUESTIONNAIRES , *BRIEF Symptom Inventory , *URINALYSIS , *SECONDARY analysis - Abstract
Objective Chronic non-cancer pain (CNCP) is prevalent among individuals with opioid use disorder (OUD). However, the impact of CNCP on buprenorphine treatment outcomes is largely unknown. In this secondary analysis, we examined treatment outcomes among individuals with and without CNCP who received a low-barrier buprenorphine maintenance regimen during waitlist delays to more comprehensive opioid treatment. Methods Participants were 28 adults with OUD who received 12 weeks of buprenorphine treatment involving bimonthly clinic visits, computerized medication dispensing, and phone-based monitoring. At intake and monthly follow-up assessments, participants completed the Brief Pain Inventory, Beck Anxiety Inventory, Beck Depression Inventory (BDI-II), Brief Symptom Inventory (BSI), Addiction Severity Index, and staff-observed urinalysis. Results Participants with CNCP (n = 10) achieved comparable rates of illicit opioid abstinence as those without CNCP (n = 18) at weeks 4 (90% vs 94%), 8 (80% vs 83%), and 12 (70% vs 67%) (P = 0.99). Study retention was also similar, with 90% and 83% of participants with and without CNCP completing the 12-week study, respectively (P = 0.99). Furthermore, individuals with CNCP demonstrated significant improvements on the BDI-II and Global Severity Index subscale of the BSI (P < 0.05). However, those with CNCP reported more severe medical problems and smaller reductions in legal problems relative to those without CNCP (P = 0.03). Conclusions Despite research suggesting that chronic pain may influence OUD treatment outcomes, participants with and without CNCP achieved similar rates of treatment retention and significant reductions in illicit opioid use and psychiatric symptomatology during low-barrier buprenorphine treatment. [ABSTRACT FROM AUTHOR]
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- 2021
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37. Conversion of Schedule II Opioids to Buprenorphine Buccal Film: A Retrospective Analysis.
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Zimmerman, Amanda, Bikdash, Rami, and Rauck, Richard
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NARCOTICS , *CHRONIC pain , *GENERIC drug substitution , *ACQUISITION of data methodology , *ANALGESICS , *BUPRENORPHINE , *RETROSPECTIVE studies , *MORPHINE , *DRUG prescribing , *MEDICAL records , *BUCCAL administration , *PHYSICIAN practice patterns , *ELECTRONIC health records , *PAIN management - Abstract
Objective To provide clinical data for the conversion of Schedule II opioids to buprenorphine buccal film and to demonstrate sustained analgesia and a reduction in morphine milligram equivalents after conversion. Design Retrospective review of electronic medical records. Setting Group clinical practice providing outpatient chronic pain management care in Winston-Salem, North Carolina. Subjects Patients who received opioids for chronic pain between January 1, 2016, and June 30, 2019, were selected for chart review if they were converted to buprenorphine buccal film from a Schedule II opioid. Methods Patients who met inclusion criteria were stratified into subgroups on the basis of preconversion morphine milligram equivalents, whether they remained on opioids for breakthrough pain postconversion, and pre- and postconversion numerical rating scale pain scores. Outcomes of interest included the differences between pre- and postconversion numerical rating scale pain scores and daily morphine milligram equivalents for each subgroup. Results Of 157 patients reviewed, 87.9% were successfully converted to buprenorphine buccal film. Overall, numerical rating scale pain scores were stable after conversion. Statistically significant reductions were demonstrated in the <90 daily morphine milligram equivalent subgroup. Postconversion daily morphine milligram equivalents decreased by 85.4% from baseline. Change in daily morphine milligram equivalents is representative of patients who remained on breakthrough pain medication. Conclusions Results demonstrate continued analgesia after conversion to buprenorphine buccal film despite reductions in daily morphine milligram equivalents. Most patients were able to convert directly from their long-acting opioid to buprenorphine buccal film and stabilized without the use of concomitant opioids for breakthrough pain. Aggressive titration strategies were associated with greater success. [ABSTRACT FROM AUTHOR]
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- 2021
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38. "We Need to Taper." Interviews with Clinicians and Pharmacists About Use of a Pharmacy-Led Opioid Tapering Program.
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Firemark, Alison J, Schneider, Jennifer L, Kuntz, Jennifer L, Papajorgji-Taylor, Dea, Dickerson, John F, Thorsness, Lou Ann, Reese, Katherine R, Sullivan, Mark D, Debar, Lynn L, and Smith, David H
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NARCOTICS , *ATTITUDES of medical personnel , *ANALGESICS , *PHYSICIANS' attitudes , *INTERVIEWING , *PHARMACISTS , *QUALITATIVE research , *COMPARATIVE studies , *DRUG therapy , *DESCRIPTIVE statistics , *CONTENT analysis , *PATIENT safety - Abstract
Objective To identify factors that influence or interfere with referrals by primary care providers (PCPs) to a pharmacist-led telephone-based program to assist patients undergoing opioid tapering. The Support Team Onsite Resource for Management of Pain (STORM) program provides individualized patient care and supports PCPs in managing opioid tapers. Design Qualitative interviews were conducted with referring PCPs and STORM staff. Interview guides addressed concepts from the RE-AIM framework, focusing on issues affecting referral to the STORM program. Setting An integrated healthcare system (HCS) in the Northwest United States. Subjects Thirty-five interviews were conducted with 20 PCPs and 15 STORM staff. Methods Constant comparative analysis was used to identify key themes from interviews. A codebook was developed based on interview data and a qualitative software program was used for coding, iterative review, and content analysis. Representative quotes illustrate identified themes. Results Use of the STORM opioid tapering program was influenced by PCP, patient, and HCS considerations. Factors motivating use of STORM included lack of PCP time to support chronic pain patients requiring opioid tapering and the perception that STORM is a valued partner in patient care. Impediments to referral included PCP confidence in managing opioid tapering, patient resistance to tapering, forgetting about program availability, and PCP resistance to evolving guidelines regarding opioid tapering goals. Conclusions PCPs recognized that STORM supported patient safety and reduced clinician burden. Utilization of the program could be improved through ongoing PCP education about the service and consistent co-location of STORM pharmacists within primary care clinics. [ABSTRACT FROM AUTHOR]
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- 2021
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39. Systemic Opioid Prescribing Patterns and Total Cost of Care in Patients Initiating Spinal Cord Stimulation Therapy: A Retrospective Analysis.
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Fraifeld, Eduardo M, Hatheway, John A, and Ricker, Christine N
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CHRONIC pain treatment , *NARCOTICS , *SPINAL cord , *ANALGESICS , *MEDICAL care costs , *RETROSPECTIVE studies , *DRUG prescribing , *HEALTH insurance , *DRUG therapy , *PHYSICIAN practice patterns , *TERMINATION of treatment , *NEURAL stimulation - Abstract
Background Few studies have evaluated patterns of systemic opioid use among patients initiating spinal cord stimulation therapy for chronic pain. This study evaluated systemic opioid discontinuation and/or dose reduction and total health care cost after the start of spinal cord stimulation therapy. Methods Using a commercial insurance claims database (2008–2017), we analyzed opioid utilization patterns in patients initiating spinal cord stimulation therapy over a 1-year baseline and 2-year follow-up. The primary end point was defined as either discontinuation (≥365-day gap between prescription fills or total days' supply in follow-up ≤30 days) or ≥50% reduction in average daily morphine milligram equivalent dose. "Costs" were defined as total payer plus patient out-of-pocket payments. Results A total of 5,878 patients met the selection criteria. Of these, 152 (2.6%) showed no opioid prescription data at any point in the study period. Among patients with one or more prescriptions, 42.0% met the primary end point (22.0% discontinued, and 20.0% reduced their dose by 50% or more). Mean total adjusted costs were significantly reduced in years 1 and 2 of follow-up relative to baseline (excluding device insertion costs). The average time to breakeven when accounting for device trial and permanent insertion cost was 3.1 years among those who met the composite end point and 4.2 years among those who did not. Conclusions This analysis shows that among patients who continued spinal cord stimulation therapy for at least 2 years, a significant proportion were able to reduce and/or discontinue systemic opioid use, with costs after the start of therapy significantly reduced relative to baseline. [ABSTRACT FROM AUTHOR]
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- 2021
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40. Effect of Drug Disposal Kits and Fact Sheets on Elimination of Leftover Prescription Opioids: The DISPOSE Multi-Arm Randomized Controlled Trial.
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Bicket, Mark C, Fu, Denise, Swarthout, Meghan D, White, Elizabeth, Nesbit, Suzanne A, and Monitto, Constance L
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NARCOTICS , *ANALGESICS , *WASTE management , *RANDOMIZED controlled trials , *TEACHING aids , *MEDICAL prescriptions - Abstract
Objective To determine how passively providing informational handouts and/or drug disposal kits affects rates of leftover prescription opioid disposal. Design A multi-arm parallel-group randomized controlled trial with masked outcome assessment and computer-guided randomization. Setting Johns Hopkins Health System outpatient pharmacies. Subjects Individuals who filled ≥1 short-term prescription for an immediate-release opioid for themselves or a family member. Methods In June 2019, 499 individuals were randomized to receive an informational handout detailing U.S. Food and Drug Administration–recommended ways to properly dispose of leftover opioids (n = 188), the informational handout and a drug disposal kit with instructions on its use (n = 170), or no intervention (n = 141) at prescription pickup. Subjects were subsequently contacted by telephone, and outcomes were assessed by a standardized survey. The primary outcome was the use of a safe opioid disposal method. Results By 6 weeks after prescription pickup, 227 eligible individuals reported they had stopped taking prescription opioids to treat pain and had leftover medication. No difference in safe disposal was observed between the non-intervention group (10% [6/63]) and the group that received disposal kits (14% [10/73]) (risk ratio = 1.44; 95% confidence interval: 0.55 to 3.74) or the group that received a fact sheet (11% [10/91]) (risk ratio = 1.15; 95% confidence interval: 0.44 to 3.01). Conclusions These findings suggest that passive provision of a drug disposal kit at prescription pickup did not increase rates of leftover opioid disposal when compared with provision of a fact sheet alone or no intervention. Active interventions may deserve further investigation. [ABSTRACT FROM AUTHOR]
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- 2021
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41. Low Back Pain and Substance Use: Diagnostic and Administrative Coding for Opioid Use and Dependence Increased in U.S. Older Adults with Low Back Pain.
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Hogans, Beth B, Siaton, Bernadette C, Taylor, Michelle N, Katzel, Leslie I, and Sorkin, John D
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THERAPEUTIC use of narcotics , *DIAGNOSIS of drug addictions , *SUBSTANCE abuse diagnosis , *LUMBAR pain , *NARCOTICS , *ALCOHOLISM , *ANALGESICS , *AGE distribution , *CROSS-sectional method , *GERIATRICS , *RACE , *NICOTINE , *SEX distribution , *HEALTH insurance reimbursement , *DESCRIPTIVE statistics , *AGING , *STATISTICAL sampling , *DRUG utilization , *MEDICAL coding , *MEDICARE , *PROBABILITY theory , *PAIN management , *MEDICAL research , *OLD age - Abstract
Objective Low back pain (LBP) is a leading cause of pain and disability. Substance use complicates the management of LBP, and potential risks increase with aging. Despite implications for an aging, diverse U.S. population, substance use and LBP comorbidity remain poorly defined. The objective of this study was to characterize LBP and substance use diagnoses in older U.S. adults by age, gender, and race. Design Cross-sectional study of a random national sample. Subjects Older adults including 1,477,594 U.S. Medicare Part B beneficiaries. Methods Bayesian analysis of 37,634,210 claims, with 10,775,869 administrative and 92,903,649 diagnostic code assignments. Results LBP was diagnosed in 14.8±0.06% of those more than 65 years of age, more in females than in males (15.8±0.08% vs. 13.4±0.09%), and slightly less in those more than 85 years of age (13.3±0.2%). Substance use diagnosis varied by substance: nicotine, 9.6±0.02%; opioid, 2.8±0.01%; and alcohol, 1.3±0.01%. Substance use diagnosis declined with advancing age cohort. Opioid use diagnosis was markedly higher for those in whom LBP was diagnosed (10.5%) than for those not diagnosed with LBP (1.5%). Most older adults (54.9%) with an opioid diagnosis were diagnosed with LBP. Gender differences were modest. Relative rates of substance use diagnoses in LBP were modest for nicotine and alcohol. Conclusions Older adults with LBP have high relative rates of opioid diagnoses, irrespective of gender or age. Most older adults with opioid-related diagnoses have LBP, compared with a minority of those not opioid diagnosed. In caring for older adults with LBP or opioid-related diagnoses, health systems must anticipate complexity and support clinicians, patients, and caregivers in managing pain comorbidities. Older adults may benefit from proactive incorporation of non-opioid pain treatments. Further study is needed. [ABSTRACT FROM AUTHOR]
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- 2021
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42. Exploring Patient Perceptions of Opioid Treatment Agreements in a Community Health Center Environment.
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Irwin, Adriane N, Braden-Suchy, Natalea, and Hartung, Daniel M
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NARCOTICS , *ANALGESICS , *RESEARCH methodology , *MEDICAL care , *PATIENTS , *INTERVIEWING , *FEAR , *SOCIAL stigma , *PATIENTS' attitudes , *QUALITATIVE research , *PATIENT-professional relations , *MEDICAID , *PATIENT education , *PAIN management - Abstract
Objective Describe patient attitudes toward opioid treatment agreements (OTAs) and characterize perceptions of their impact on patient care, behavior, communication with prescribers, and engagement with the health care system. Design Qualitative descriptive study. Setting Federally qualified health center with six clinic locations serving a rural population. Subjects Patients were prescribed long-term opioid therapy and were required to sign an OTA through an in-person office visit with a clinical pharmacist. Methods Patients who signed an OTA were recruited to participate in semistructured, in-person, one-on-one interviews. Data were analyzed using immersion-crystallization methods. Results Among the 20 patients recruited, 50% were men; 70% were insured by the state's Medicaid program; and 85% were using opioids for hip, back, and/or neck pain. Four major themes arose from the interviews. First, individuals who use long-term opioids experience a wide variety of opioid-related fears and stigmas. Second, individuals articulated real or potential benefits from implementing OTAs. Third, opinions differed on whether OTAs affected behavior and reduced opioid misuse and diversion. Finally, individuals provided feedback on the health care system's OTA implementation process. Conclusions Patients experienced a wide variety of opioid-related fears and stigmas, including how OTA requirements can perpetuate these issues. Despite these feelings, participants articulated real or potential positive outcomes from the use of OTAs, although they were mixed on whether these agreements translated to any behavior changes. If OTAs are to become standard practice, future research is needed to describe the diversity of patient perspectives and experiences with OTAs and to evaluate their effect on patient outcomes. [ABSTRACT FROM AUTHOR]
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- 2021
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43. Cannabis Significantly Reduces the Use of Prescription Opioids and Improves Quality of Life in Authorized Patients: Results of a Large Prospective Study.
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Lucas, Philippe, Boyd, Susan, Milloy, M.-J., and Walsh, Zach
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NARCOTICS , *CANNABIS (Genus) , *GENERIC drug substitution , *ANALGESICS , *HARM reduction , *DRUG prescribing , *QUALITY of life , *QUESTIONNAIRES , *DESCRIPTIVE statistics , *PHYSICIAN practice patterns - Abstract
Objectives This article presents findings from a large prospective examination of Canadian medical cannabis patients, with a focus on the impacts of cannabis on prescription opioid use and quality of life over a 6-month period. Methods The Tilray Observational Patient Study took place at 21 medical clinics throughout Canada. This analysis includes 1,145 patients who had at least one postbaseline visit, with follow-up at 1, 3, and 6 months. Instruments included a comprehensive cannabis use inventory, the World Health Organization Quality of Life Short Form (WHOQOL-BREF), and a detailed prescription drug questionnaire. Results Participants were 57.6% female, with a median age of 52 years. Baseline opioid use was reported by 28% of participants, dropping to 11% at 6 months. Daily opioid use went from 152 mg morphine milligram equivalent (MME) at baseline to 32.2 mg MME at 6 months, a 78% reduction in mean opioid dosage. Similar reductions were also seen in the other four primary prescription drug classes identified by participants, and statistically significant improvements were reported in all four domains of the WHOQOL-BREF. Conclusions This study provides an individual-level perspective of cannabis substitution for opioids and other prescription drugs, as well as associated improvement in quality of life over 6 months. The high rate of cannabis use for chronic pain and the subsequent reductions in opioid use suggest that cannabis may play a harm reduction role in the opioid overdose crisis, potentially improving the quality of life of patients and overall public health. [ABSTRACT FROM AUTHOR]
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- 2021
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44. Acute Cervical Radiculopathy Outcomes: Soft Disc Herniations vs Osteophytes.
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Beckworth, William Jeremy, Abramoff, Benjamin A, Bailey, Iain M, Yoon, Sook, Umpierrez, Monica, Kakarala, Aparna, Lee, Jacob Y, Ward, Laura A, Dows-Martinez, Marly N, and Yoon, S Tim
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METAPLASTIC ossification , *PATIENT aftercare , *NARCOTICS , *INTERVERTEBRAL disk displacement , *EXOSTOSIS , *PAIN measurement , *NECK pain , *CONFIDENCE intervals , *BACKACHE , *MAGNETIC resonance imaging , *RADICULOPATHY , *TREATMENT effectiveness , *DESCRIPTIVE statistics , *DIAGNOSIS of musculoskeletal system diseases , *ACUTE diseases , *LONGITUDINAL method , *MOTOR ability , *EVALUATION - Abstract
Objective Prospectively evaluate the clinical outcomes of acute cervical radiculopathy with respect to soft disc herniations vs osteophytes. Methods Sixty consecutive patients who had had cervical radiculopathy for ≤1 month were enrolled in the study. Inclusion criteria were radicular pain greater than axial pain and a pain score ≥4 out of 10 on a numerical rating scale. Patients had at least one positive clinical finding: motor, sensory, or reflex changes. Plain films and magnetic resonance imaging were ordered. Follow-up was at 6 weeks and 3, 6, and 12 months. Outcomes included pain scores (neck and upper limb), neck disability index, medication use, opioid use, and need for surgery. Two attending musculoskeletal radiologists reviewed imaging findings for osteophytes vs soft disc herniations at the symptomatic level. Results More than 75% reduction in pain was seen in 77% of patients with soft disc herniations and 66% of patients with osteophytes (P > 0.05) at 12 months. A pain score ≤2 out of 10 within 6 to 12 months was seen in 86% of patients with soft disc herniations and 81% of patients with osteophytes (P > 0.05). Moderate or marked improvement at 12 months was seen in 85% of patients with soft discs and 77% of patients with osteophytes (P > 0.05). Baseline–to–12-month numerical rating scale pain scores of patients with soft discs vs osteophytes had overlapping confidence intervals at each follow-up. At 12 months, very few had undergone surgery (7% of patients with soft discs, 11% of patients with osteophytes; P > 0.05) or were on opioids (7% of patients with soft discs, 9% of patients with osteophytes; P > 0.05). Conclusions The majority of patients, but not all patients, with acute radiculopathies improved with time. This was seen with both soft disc herniations and osteophytes. [ABSTRACT FROM AUTHOR]
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- 2021
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45. Gaps in the Use of Long-Acting Opioids Within Intervals of Consecutive Days Among Cancer Outpatients Using Electronic Pill Caps.
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Meghani, Salimah H, Persico, Amelia L, Fudin, Jeffrey, and Knafl, George J
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NARCOTICS , *CANCER pain , *ANALGESICS , *SELF-management (Psychology) , *CANCER patients , *DRUGS , *PATIENT compliance , *ELECTRONICS , *SECONDARY analysis - Abstract
Objective This study describes individual cancer patients' nonuse of extended-release or long-acting (ER/LA) opioids, including periods of gap between opioid doses taken. Design Secondary analysis of a three-month observational study of prescribed ER/LA opioids monitored using electronic pill caps. Setting Two outpatient oncology clinics of a large health system in the Mid-Atlantic region. Participants Inclusion was based on self-identified African Americans and whites, at least 18 years old, diagnosed with solid tumors or multiple myeloma. For the current analysis, the additional inclusion criterion was prescription of an oral ER/LA opioid for cancer pain to be taken around the clock. Methods The electronic monitoring period for each study participant was partitioned into intervals of days between days with one or more openings (using medication event monitoring systems) representing rates of ER/LA opioid nonuse over consecutive days and over time. Results Of the sample (N = 109), two-thirds of the cancer patients had some nonuse of prescribed ER/LA opioids, with one in four having nonuse during 31.5–87.5% of their electronic-monitoring periods. Nonuse over periods of five or more, six or more, and seven or more consecutive days occurred for 37.6%, 34.9%, and 30.3% of the participants, respectively. Conclusions About one in three ambulatory cancer patients in this study had substantial gaps between days of ER/LA opioid use, potentially resulting in risk of overdose depending upon the prescribed ER/LA opioid type, dose, and length of the time the opioid was stopped and resumed at the previous dose. This phenomenon has received little to no attention in the opioid safety discourse. [ABSTRACT FROM AUTHOR]
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- 2021
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46. Alternatives to Opioid Education and a Prescription Drug Monitoring Program Cumulatively Decreased Outpatient Opioid Prescriptions.
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Sigal, Adam, Shah, Ankit, Onderdonk, Alex, Deaner, Traci, Schlappy, David, and Barbera, Charles
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NARCOTICS , *SUBSTANCE abuse , *DRUG overdose , *PATIENTS , *MORPHINE , *DRUG prescribing , *DRUG monitoring , *QUALITY assurance , *MEDICAL prescriptions , *PHYSICIAN practice patterns , *ELECTRONIC health records , *DISCHARGE planning - Abstract
Introduction Deaths have increased, and prescription medications are involved in a significant percentage of deaths. Emergency department (ED) changes to managing acute pain and prescription drug monitoring programs (PDMPs) can impact the potential for abuse. Methods We analyzed the impact of a series of quality improvement initiatives on the opioid prescribing habits of emergency department physicians and advanced practice providers. We compared historical prescribing patterns with those after three interventions: 1) the implementation of a PDMP, 2) clinician education on alternatives to opioids (ALTOs), and 3) electronic health record (EHR) process changes. Results There was a 61.8% decrease in the percentage of opioid-eligible ED discharges that received a prescription for an opioid from 19.4% during the baseline period to 7.4% during the final intervention period. Among these discharges, the cumulative effect of the interventions resulted in a 17.3% decrease in the amount of morphine milligram equivalents (MME) prescribed per discharge from a mean of 104.9 MME/discharge during the baseline period to 86.8 MME/discharge. In addition, the average amount of MME prescribed per discharge became aligned with recommended guidelines over the intervention periods. Conclusions Initiating a PDMP and instituting an aggressive ALTO program along with EHR-modified process flows have cumulative benefits in decreasing MME prescribed in an acute ED setting. [ABSTRACT FROM AUTHOR]
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- 2021
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47. Nationally Representative Health Care Expenditures of Community-Based Older Adults with Pain in the United States Prescribed Opioids vs Those Not Prescribed Opioids.
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Axon, David R, Slack, Marion, Barraza, Leila, Lee, Jeannie K, and Warholak, Terri
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NARCOTICS , *PAIN , *ANALGESICS , *CROSS-sectional method , *MEDICAL care costs , *NONPRESCRIPTION drugs , *REGRESSION analysis , *INDEPENDENT living , *DRUGS , *DESCRIPTIVE statistics , *ECONOMIC aspects of diseases - Abstract
Objective To compare health care expenditures between older US adults (≥50 years) with pain who were prescribed opioid medications and those who were not. Design Cross-sectional. Setting Community-based adults in the 2015 Medical Expenditure Panel Survey (MEPS). Subjects Nationally representative sample of US adults alive for the calendar year, aged 50 years or older, who reported having pain in the past four weeks. Methods Older US adults (≥50 years) with pain in the 2015 MEPS data were identified. The key independent variable was opioid prescription status (prescribed opioid vs not prescribed opioid). Hierarchical linear regression models assessed health care expenditures (inpatient, outpatient, office-based, emergency room, prescription medications, other, and total) in US dollars for opioid prescription status from a community-dwelling US population perspective, adjusting for covariates. Results The 2015 study cohort provided a national estimate of 50,898,592 noninstitutionalized US adults aged ≥50 years with pain in the past four weeks (prescribed opioid N = 16,757,516 [32.9%], not prescribed opioid N = 34,141,076 [67.1%]). After adjusting for covariates, individuals prescribed an opioid had 61% greater outpatient (β = 0.477, P < 0.0001), 69% greater office-based (β = 0.524, P < 0.0001), 14% greater emergency room (β = 0.131, P = 0.0045), 63% greater prescription medication (β = 0.486, P < 0.0001), 29% greater other (β = 0.251, P = 0.0002), and 105% greater total (β = 0.718, P < 0.0001) health care expenditures. There was no difference in opioid prescription status for inpatient expenditures (P > 0.05). Conclusions This study raises awareness of the economic impact associated with opioid use among US older adults with pain. Future research should investigate these variables in greater depth, over longer time periods, and in additional populations. [ABSTRACT FROM AUTHOR]
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- 2021
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48. Patient-Reported Opioid Pill Consumption After an ED Visit: How Many Pills Are People Using?
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McCarthy, Danielle M, Kim, Howard S, Hur, Scott I, Lank, Patrick M, Arroyo, Christine, Opsasnick, Lauren A, Piserchia, Katherine, Curtis, Laura M, Wolf, Michael S, and Courtney, D Mark
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MUSCULOSKELETAL system injuries , *NARCOTICS , *HOSPITAL emergency services , *PAIN , *ACADEMIC medical centers , *ANALGESICS , *RESEARCH methodology , *ACETAMINOPHEN , *HEALTH outcome assessment , *BACKACHE , *COLIC , *JOINT dislocations , *PATIENTS' attitudes , *MORPHINE , *DESCRIPTIVE statistics , *MEDICAL appointments , *MEDICAL prescriptions , *METROPOLITAN areas , *PAIN management , *ACUTE diseases , *PATIENT safety , *BONE fractures ,EVALUATION of drug utilization - Abstract
Objectives Recent guidelines advise limiting opioid prescriptions for acute pain to a three-day supply; however, scant literature quantifies opioid use patterns after an emergency department (ED) visit. We sought to describe opioid consumption patterns after an ED visit for acute pain. Design Descriptive study with data derived from a larger interventional study promoting safe opioid use after ED discharge. Setting Urban academic emergency department (>88,000 annual visits). Subjects Patients were eligible if age >17 years, not chronically using opioids, and newly prescribed hydrocodone-acetaminophen and were included in the analysis if they returned the completed 10-day medication diary. Methods Patient demographics and opioid consumption are reported. Opioid use is described in daily number of pills and daily morphine milligram equivalents (MME) both for the sample overall and by diagnosis. Results Two hundred sixty patients returned completed medication diaries (45 [17%] back pain, 52 [20%] renal colic, 54 [21%] fracture/dislocation, 40 [15%] musculoskeletal injury [nonfracture], and 69 [27%] "other"). The mean age (SD) was 45 (15) years, and 59% of the sample was female. A median of 12 pills were prescribed. Patients with renal colic used the least opioids (total pills: median [interquartile range {IQR}] = 3 [1–7]; total MME: median [IQR] = 20 [10–50]); patients with back pain used the most (total pills: median [IQR] = 12 [7–16]; total MME: median [IQR] = 65 [47.5–100]); 92.5% of patients had leftover pills. Conclusions In this sample, pill consumption varied by illness category; however, overall, patients were consuming low quantities of pills, and the majority had unused pills 10 days after their ED visit. [ABSTRACT FROM AUTHOR]
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- 2021
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49. "Living Well with Chronic Pain": Integrative Pain Management via Shared Medical Appointments.
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Znidarsic, Josie, Kirksey, Kellie N, Dombrowski, Stephen M, Tang, Anne, Lopez, Rocio, Blonsky, Heather, Todorov, Irina, Schneeberger, Dana, Doyle, Jonathan, Libertini, Linda, Jamie, Starkey, Segall, Tracy, Bang, Andrew, Barringer, Kathy, Judi, Bar, Ehrman, Jane Pernotto, Roizen, Michael F, and Golubić, Mladen
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CHRONIC pain treatment , *ACUPRESSURE , *ACUPUNCTURE , *ANALGESICS , *CHRONIC pain , *COGNITIVE therapy , *HEALTH , *HEALTH care teams , *PATIENT aftercare , *OUTPATIENT services in hospitals , *HYPNOTISM , *MASSAGE therapy , *MEDICAL needs assessment , *MORPHINE , *NARCOTICS , *HEALTH outcome assessment , *PATIENT education , *QUALITY of life , *QUESTIONNAIRES , *RESPIRATION , *SELF-evaluation , *SPINAL adjustment , *YOGA , *PAIN management , *EVIDENCE-based medicine , *INTEGRATIVE medicine , *GROUP medical appointments , *LIFESTYLES , *TREATMENT effectiveness , *PRE-tests & post-tests , *RETROSPECTIVE studies , *RELAXATION techniques - Abstract
Objective To evaluate the effectiveness of a multidisciplinary, nonpharmacological, integrative approach that uses shared medical appointments to improve health-related quality of life and reduce opioid medication use in patients with chronic pain. Design This is a retrospective, pre–post review of "Living Well with Chronic Pain" shared medical appointments (August 2016 through May 2018). Setting The appointments included eight 3-hour-long visits held once per week at an outpatient wellness facility. Subjects Patients with chronic, non–cancer-related pain. Methods Patients received evaluation and evidence-based therapies from a team of integrative and lifestyle medicine professionals, as well as education about nonpharmacological therapeutic approaches, the etiology of pain, and the relationship of pain to lifestyle factors. Experiential elements focused on the relaxation techniques of meditation, yoga, breathing, and hypnotherapy, while patients also received acupuncture, acupressure, massage, cognitive behavioral therapy, and chiropractic education. Patients self-reported data via the Patient-Reported Outcomes Measurement Information System (PROMIS-57) standardized questionnaire. Use of opioid medications was evaluated in morphine milligram equivalents. Results A total of 178 participants completed the PROMIS-57 questionnaire at the first and the last visits. Statistically significant improvements in all domains (Physical Functioning, Anxiety, Depression, Fatigue, Social Roles, Pain Interference, and Sleep Disturbance) were observed (P < 0.001) between the pre-intervention (visit 1) and post-intervention (visit 8) scores. Average opioid use decreased nonsignificantly over the 8-week intervention, but the lower rate of opioid use was not sustained at 6 and 12 months' follow-up. Conclusions Patients suffering from chronic pain who participated in a multidisciplinary, nonpharmacological treatment approach delivered via shared medical appointments experienced reduced pain and improved measures of physical, mental, and social health without increased use of opioid pain medications. [ABSTRACT FROM AUTHOR]
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- 2021
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50. Addressing the Public Health Crisis of Excessive Opioid Prescribing and Inadequate Pain Management Through Closing the Pain Education Gap.
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Fishman, Scott M
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PREVENTION of epidemics , *CLINICAL competence , *DRUG prescribing , *NARCOTICS , *OPIOID abuse , *PAIN , *PRIMARY health care , *PUBLIC health , *TELEMEDICINE , *PAIN management , *PHYSICIAN practice patterns , *PAIN measurement , *INAPPROPRIATE prescribing (Medicine) - Abstract
The article addressing the Public Health Crisis of Excessive Opioid Prescribing and Inadequate Pain Management through closing the Pain Education Gap. Topics discussed include the Institute of Medicine released its seminal report Relieving Pain in America, which affirmed that pain receives insufficient attention in virtually; and the problem of reducing essential competencies in pain management simply to pain recognition is highlighted.
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- 2021
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