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The article by Bhasin et al. [[1]] compared various clinical, biochemical and echocardiographic markers of myocardial dysfunction in neonates with and without perinatal asphyxia. Despite the title (Myocardial dysfunction as a predictor of the severity and mortality of hypoxic-ischaemic encephalopathy in severe perinatal asphyxia: a case-control study), the results do not fully support it. The optimal way to present such conclusions in a case-control study is by calculating odds ratios and risk ratios. [Extracted from the article]

We read the article by Khuwuthyakorn et al. [[1]] which compared the efficacy of oral ibuprofen and oral indomethacin in very low-birthweight (VLBW) infants. Recent evidence shows that paracetamol is as effective as other therapies and remains a good alternative therapeutic agent when ibuprofen and indomethacin are contraindicated. Association of placebo, indomethacin, ibuprofen, and acetaminophen with closure of hemodynamically significant patent ductus arteriosus in preterm infants: a systematic review and meta-analysis. [Extracted from the article]

We read with interest the article by Prashantha et al. regarding the safety of low-cost devices for therapeutic hypothermia (TH) in low- and middle-income countries (LMIC) such as India [[1]] and wish to make certain points. For it to be standard care in India, its long-term efficacy needs to be proved in large multi-centre randomised controlled trials (RCT) following standard study protocols. [Extracted from the article]