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Protein analysing examinations were carried through in children--fit to be compared to their age--suffering from inflammable ear diseases (acute middle ear inflammation, mastoiditis) and those who were healthy as to their ears. The obtained values statistically analysed resulted in significant differences as to the acute phase and those of closely associated proteins in the sense that haptoglobin, C3c and C1-inactivators in patients with a mastoiditis and partially in those who suffered from an acute middle ear inflammation were increased but prealbumin and transferrin in the same group were decreased. Subsequently the correlative connections of the parameters with singled-out clinical findings in the mastoiditis-group were examined. A factor of the acute phase, a factor of the subacute phase and the immunoglobulin factor could have been marked off, whereby the two first-mentioned are significant for mastoiditis, a fact that will help to facilitate the decision on further therapeutical practice. Presently there are no specific proteins for diagnostics of 'mastoiditis', so that to clinical expertness and experience of the therapeutist will come up the most significant role for the ill child.