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The hidden epidemic of burnout exacts a staggering toll on professionals and patients, reflected in increased risk of medical errors, complications, and staff turnover. For surgeons, nurses, and other team members working at the sharp end of care, adverse events can amplify work exhaustion, interpersonal disengagement, and risk of moral adversity. Visionary leaders are not content to mitigate burnout and moral injury; they elevate the human experience throughout health care by modeling wellness, fostering moral courage, promoting safety of professionals, and restoring joy in work. Part 3, Health Professional Wellness and Resilience, introduces the final pillar for advancing the clinical mission., (Copyright © 2021 Elsevier Inc. All rights reserved.)

At the foundation of clinical medicine is the relationship among patients, families, and health care professionals. Implicit to that social contract, professionals pledge to bring clinical excellence to advance their patients' wellness and healing-and to prevent harm. Patients trust that those privileged to deliver care will do so unwaveringly in service of patients' best interests; however, the incentives and infrastructure surrounding health care delivery can promote or undermine individual performance, teamwork, and patient safety. Modeling professionalism and identifying slips and lapses supports pursuit of high reliability. Part 1, Promoting Professionalism, introduces the first of 3 pillars of advancing the clinical mission., (Copyright © 2021 Elsevier Inc. All rights reserved.)

When patients are harmed by health care, concerns fan out in all directions. Patients and families confront a sea of uncertainty, contending with injuries that drain them physically, emotionally, and financially. Health care professionals experience a powerful mix of emotions, but are seldom afforded the time to process what happened or the resources to relieve suffering and prevent harm. Honesty, transparency, and empathy are indispensable to a comprehensive approach that prioritizes patient and family-centered response to unintended harm, clinical improvement, and redemptive peer review. Part 2 introduces the second of three pillars for advancing the clinical mission: communication and transparency., Competing Interests: Conflict of interest and disclosure R.C. Boothman, JD, is Owner and Principal of Boothman Consulting, which assists health systems in transitioning to communication and resolutions programs, conducting programmatic and personal peer review, and designing peer review approaches. Dr G.B. Hickson is an employee of Vanderbilt University Medical Center and is a member of Medtronic’s speakers bureau. He receives royalties from Cognitive Institute; and has received payment for the development of educational presentations from numerous health care institutions. Dr G.B. Hickson is also a member of the USC Health System Board and Vice Chair of the Institute for Healthcare Improvement (IHI) Board. No other authors have disclosures relevant to this publication., (Copyright © 2021 Elsevier Inc. All rights reserved.)