1. [Diagnostic difficulties caused by a pulmonary infiltrate].
- Author
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Simon Z, Jóna A, Miltényi Z, Páyer E, Lieber A, Szilasi M, and Illés A
- Subjects
- Adult, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Biopsy methods, Bleomycin administration & dosage, Dacarbazine administration & dosage, Diagnosis, Differential, Doxorubicin administration & dosage, Fluorodeoxyglucose F18, Hodgkin Disease blood, Hodgkin Disease complications, Hodgkin Disease drug therapy, Humans, Lung diagnostic imaging, Lung Neoplasms blood, Lung Neoplasms complications, Lung Neoplasms drug therapy, Male, Multimodal Imaging methods, Positron-Emission Tomography, Remission Induction, Tomography, X-Ray Computed, Treatment Outcome, Vinblastine administration & dosage, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Biomarkers, Tumor blood, Fever of Unknown Origin etiology, Hodgkin Disease diagnosis, Lung pathology, Lung Neoplasms diagnosis
- Abstract
Unlabelled: Lung infiltration still causes differential diagnostic difficulties, which may delay the start of definitive treatment., Case Report: The examination of a 30-year-old man began due intermittent, remittent and permanent fever. Chest X-ray confirmed infiltration in the right upper lobe, which was accompanied by elevated CRP and physiological levels of procalcitonin. Most likely atypical pneumonia, tuberculosis, Wegener's granulomatosis or a malignant process was suspected. Throughout his examination infection could not be verified, repeated CT guided transthoracic needle biopsy suggested the possibility of a malignant process. Through surgical exploration the intraoperative histology was not informative; thus, the pneumonitis-remodelled right lung was removed due to the possibility of malignant transformation. Histological examination revealed lymphocyte rich classical Hodgkin lymphoma, which was found to be stage IV/B based on the 18FDG-PET/CT scan; therefore, eight cycles of ABVD (adriablastin, bleomycin, vinblastine, and dacarbazine) therapy was administered successfully. The patient is currently (for 30 months) in a complete metabolic remission., Conclusion: Primary pulmonary Hodgkin lymphoma is a rare disease entity (in this case it might be the original process), in which the diagnosis is often difficult. 18FDG-PET/CT may be a useful early diagnostic tool investigating fever of unknown origin.
- Published
- 2012
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