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1. Combining two-directional synthesis and tandem reactions: a short formal synthesis of halichlorine

Author

Robert A. Stockman, Alexandre Barthelme, Marie-Lyne Alcaraz, Annabella F. Newton, Camille Gignoux, and William Lewis

Subjects
Formal synthesis, Alkaloids, Cascade reaction, Tandem, Chemistry, Halichlorine, Yield (chemistry), Organic Chemistry, Spiro Compounds, Physical and Theoretical Chemistry, Biochemistry, Combinatorial chemistry
Abstract

A short and efficient synthesis of an advanced intermediate (1) in the Clive route to halichlorine has been achieved in 12 steps and 13.2% yield by a combined two-directional synthesis/tandem reaction strategy.

Published
2011

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