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Your search keyword '"Matteo Betti"' showing total 3 results
Start Over Author "Matteo Betti" Journal organic process research & development
3 results on '"Matteo Betti"'

1. A Scalable Route to the SMO Receptor Antagonist SEN826: Benzimidazole Synthesis via Enhanced in Situ Formation of the Bisulfite–Aldehyde Complex

Author

Paul H. Wiedenau, Matteo Betti, Salvatore Sanna Coccone, Eva Genesio, and Guido Marconi

Subjects
chemistry.chemical_classification, In situ, Benzimidazole, medicine.drug_class, Stereochemistry, Organic Chemistry, Receptor antagonist, Aldehyde, Combinatorial chemistry, Bisulfite, chemistry.chemical_compound, chemistry, Scalability, medicine, Molecule, Physical and Theoretical Chemistry
Abstract

A practical and scalable route to the SMO antagonist SEN826 1 is described herein, including the discussion of an alternative approach to the synthesis of the target molecule. The optimized route consists of five chemical steps. A new and efficient access to the key intermediate 6 via the bisulfite–aldehyde complex was developed, significantly enhancing the yields and reducing costs. As a result, a synthetic procedure for preparation of multihundred gram quantities of the final product has been developed.

Published
2014
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2. Process Development and Scale-Up for the Preparation of the 1-Methyl-quinazoline-2,4-dione Wnt Inhibitor SEN461

Author

Matteo Betti, Eva Genesio, Alessandro Panico, Paul H. Wiedenau, and Salvatore Sanna Coccone

Subjects
chemistry.chemical_compound, chemistry, Process development, Organic Chemistry, Wnt inhibitor, Quinazoline, Physical and Theoretical Chemistry, Combinatorial chemistry
Abstract

A practical and scalable route to the Wnt inhibitor SEN461 1 is described herein. The optimized route consists of nine chemical steps. The intermediates are solids and were isolated by filtrations....

Published
2013
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3. Development of a Scalable Route to the SMO Receptor Antagonist SEN794

Author

Matteo Betti, Salvatore Sanna Coccone, Paul H. Wiedenau, Giulio Castagnoli, and Alessandro Panico

Subjects
Computer science, medicine.drug_class, Organic Chemistry, Scalability, medicine, Key (cryptography), Computational biology, Physical and Theoretical Chemistry, Receptor antagonist
Abstract

A practical and scalable route to the SMO receptor antagonist SEN794 1 is described herein. A new and efficient access to the key intermediate 7 via the Krohnke reaction was developed, significantl...

Published
2012
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