1. An Improved Synthesis of Memantine Hydrochloride: Anti-Alzheimer's Drug
- Author
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and Vurumidi Himabindu, Ganji Prasad, Jambula Mukunda Reddy, Ghanta Mahesh Reddy, Veeramalla Raju, and M. Ravikumar
- Subjects
Drug ,Formamide ,Anti alzheimer ,Hydrochloride ,Adamantane ,media_common.quotation_subject ,Organic Chemistry ,Combinatorial chemistry ,Memantine Hydrochloride ,chemistry.chemical_compound ,Hydrolysis ,chemistry ,Organic chemistry ,Physical and Theoretical Chemistry ,media_common - Abstract
An economical new process route has been developed for the large-scale synthesis of memantine hydrochloride (1) an anti-Alzheimer's drug. The procedure involves the conversion of 1,3-dimethyl adamantane (2) to formamide intermediate 8 as a key step, followed by hydrolysis to (1-amino-3,5-dimethyl adamantane) hydrochloride (1) in good yield.
- Published
- 2007
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