1. Development of a Scalable Synthesis of the Small Molecule TGFβR1 Inhibitor BMS-986260
- Author
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David K. Leahy, Martin D. Eastgate, Arvind Mathur, Richard Rampulla, Varadharajan Subramanian, Upender Velaparthi, Sathishkumar Chandrasekaran, Karthikeyan Chinnakalai, Arun Kumar Gupta, Antony Savarimuthu, Thirumalai Lakshminarasimhan, Souvik Rakshit, Indasi Gopikumar, Jayakumar Sankara Warrier, Chetan Padmakar Darne, Robert M. Borzilleri, Rajappa Vaidyanathan, Anuradha Gupta, Ananta Karmakar, Vignesh Radhakrishnan, Muthalagu Vetrichelvan, Dyamanna Doddalingappa, and Senthil Palani
- Subjects
stomatognathic diseases ,chemistry.chemical_compound ,Column chromatography ,chemistry ,digestive, oral, and skin physiology ,Organic Chemistry ,TosMIC ,Physical and Theoretical Chemistry ,Combinatorial chemistry ,Small molecule - Abstract
A scalable route to the small molecule TGFβR1 inhibitor BMS-986260 (1) was developed. This alternative approach circumvented the purification of intermediates by column chromatography and provided ...
- Published
- 2020