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Start Over Author "Weitao Yan" Journal organic letters
2 results on '"Weitao Yan"'

1. Copper-Catalyzed Synthesis of Indol-3-yl α-(Difluoromethyl)-α-(trifluoromethyl)carbinols: Construction of Difluoromethylated sp3 Carbon Centers

Author

Weitao Yan, Yunxiao Zhang, Zhiqiang Weng, and Yukang Wang

Subjects
Trifluoromethyl, 010405 organic chemistry, Organic Chemistry, chemistry.chemical_element, 010402 general chemistry, 01 natural sciences, Biochemistry, Medicinal chemistry, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Halogen, Nitro, Copper catalyzed, Organic chemistry, Physical and Theoretical Chemistry, Carbon
Abstract

An efficient copper-catalyzed synthesis of indol-3-yl α-(difluoromethyl)-α-(trifluoromethyl)carbinols is developed. The reaction proceeds in good to excellent yields through a Friedel–Crafts-type mechanism, and a variety of indoles with commonly occurring functional groups such as formyl, cyano, nitro, alkyloxide, and halogen are well tolerated. In addition, these carbinol products are readily transformed into diversified difluoromethylated dinitrile indol-3-yl derivatives. This strategy provides a general synthetic method for ready construction of difluoromethylated sp3 carbon centers.

Published
2017

2. Copper-Catalyzed Synthesis of Indol-3-yl α-(Difluoromethyl)-α-(trifluoromethyl)carbinols: Construction of Difluoromethylated sp

Author

Yunxiao, Zhang, Weitao, Yan, Yukang, Wang, and Zhiqiang, Weng

Abstract

An efficient copper-catalyzed synthesis of indol-3-yl α-(difluoromethyl)-α-(trifluoromethyl)carbinols is developed. The reaction proceeds in good to excellent yields through a Friedel-Crafts-type mechanism, and a variety of indoles with commonly occurring functional groups such as formyl, cyano, nitro, alkyloxide, and halogen are well tolerated. In addition, these carbinol products are readily transformed into diversified difluoromethylated dinitrile indol-3-yl derivatives. This strategy provides a general synthetic method for ready construction of difluoromethylated sp

Published
2017

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