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3 results on '"Wang, Zhao-Jie"'

1. Steroidal Alkaloids with a Potent Analgesic Effect Based on N-type Calcium Channel Inhibition

Author

Xie, Tian-Zhen, primary, Luo, Lei, additional, Zhao, Yun-Li, additional, Li, Hao, additional, Xiang, Mei-Ling, additional, Qin, Xu-Jie, additional, He, Ying-Jie, additional, Zhu, Yan-Yan, additional, Dai, Zhi, additional, Wang, Zhao-Jie, additional, Wei, Xin, additional, Liu, Ya-Ping, additional, Zhao, Li-Xing, additional, Lai, Ren, additional, and Luo, Xiao-Dong, additional

Published
2021
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3. Steroidal Alkaloids with a Potent Analgesic Effect Based on N-type Calcium Channel Inhibition

Author

Xie, Tian-Zhen, Luo, Lei, Zhao, Yun-Li, Li, Hao, Xiang, Mei-Ling, Qin, Xu-Jie, He, Ying-Jie, Zhu, Yan-Yan, Dai, Zhi, Wang, Zhao-Jie, Wei, Xin, Liu, Ya-Ping, Zhao, Li-Xing, Lai, Ren, and Luo, Xiao-Dong

Abstract

Two distinctive alkaloids with 6/6/6/5/6/6 fused rings, in which a previously unidentified linkage of C-12/23 generates a rigid skeleton, resulting in a new subtype of steroidal alkaloid, were isolated from Veratrum grandiflorum. Compounds 1and 2showed potent analgesic effects in vivo, superior to the well-known analgesic, pethidine (Dolantin), likely by inhibiting CaV2.2 voltage-gated calcium channels.

Published
2022
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