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Start Over Author "Wang, Cui" Journal organic letters
20 results on '"Wang, Cui"'

13. Asymmetric Formal Synthesis of (−)-Cephalotaxine via Palladium-Catalyzed Enantioselective Tsuji Allylation

Author

Zhang, Zhi-Wei, Wang, Cui-Cui, Xue, Hong, Dong, Yu, Yang, Jian-Hua, Liu, Shouxin, Liu, Wen-Qing, and Li, Wei-Dong Z.

Abstract

Asymmetric synthesis of the pentacyclic alkaloid (−)-cephalotaxine was accomplished via palladium-catalyzed enantioselective Tsuji allylation for construction of the aza-containing tetrasubstituted stereogenic center (95% yield, 93% ee). The allyl enol carbonate precursor was prepared from Hanaoka’s ketone intermediate, which was formed by a novel formic acid promoted ring-expansion reaction.

Published
2024
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18. OrthoC–H Hydroxyalkylation or Methylation of Aryl Iodides by Ethers and TMSI via a Catellani Strategy

Author

Zhang, Zhe, Chen, Xi, Li, Xue-Song, Wang, Cui-Tian, Niu, Zhi-Jie, Zhang, Bo-Sheng, Liu, Xue-Yuan, and Liang, Yong-Min

Abstract

In this paper, in the presence of trimethylsilyl iodide, the direct ortho-C–H hydroxyalkylation/methylation of aryl iodines was effectively realized via palladium/norbornene cooperative catalysis when low-cost tetrahydrofuran and 1,2-dimethoxyethane were used as alkyl sources. Heck, Suzuki, and Sonogashira coupling and hydrogenation were all compatible with the reaction as termination steps. In addition, neuromuscular agents and cardiovascular agents were synthesized in one step by this method, showing their potential application value.

Published
2022
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19. Ni-Catalyzed Remote Radical/Cross-Electrophile Coupling Cascade for Selective C(sp 3 )-H Arylation.

Author

Wen YT, Kong XT, Liu HC, Wang CT, Wei WX, Wang B, Liu XY, and Liang YM

Abstract

An innovative 1,5-HAT cascade strategy has been advanced for the nickel-catalyzed distal arylation via cross-electrophile coupling. Through specific migration, the remote C(sp 3 )-H bond is regioselectively activated, and Ar-I as the available electrophile is used for the construction of the C(sp 3 )-C(sp 2 ) bond. This method also has broad applicability for benzylic and aliphatic N -fluorocarboxamides with yields up to 80%. Furthermore, a series of control experiments demonstrated that this reaction is probably initiated by a radical process.

Published
2022
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20. Asymmetric Formal Synthesis of (-)-Cephalotaxine via Palladium-Catalyzed Enantioselective Tsuji Allylation.

Author

Zhang ZW, Wang CC, Xue H, Dong Y, Yang JH, Liu S, Liu WQ, and Li WZ

Abstract

Asymmetric synthesis of the pentacyclic alkaloid (-)-cephalotaxine was accomplished via palladium-catalyzed enantioselective Tsuji allylation for construction of the aza-containing tetrasubstituted stereogenic center (95% yield, 93% ee). The allyl enol carbonate precursor was prepared from Hanaoka's ketone intermediate, which was formed by a novel formic acid promoted ring-expansion reaction.

Published
2018
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