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3 results on '"Tyler A. Johnson"'

1. Azonazine, a Novel Dipeptide from a Hawaiian Marine Sediment-Derived Fungus, Aspergillus insulicola

Author

Quan-Xiang Wu, Johann Sohn, Mitchell S. Crews, Phillip Crews, Tyler A. Johnson, Marija Draskovic, Leonard F. Bjeldanes, Frederick A. Valeriote, Karen Tenney, and Xiao-Jun Yao

Subjects
Models, Molecular, Molecular model, Cell Survival, Stereochemistry, Fungus, Biochemistry, Article, Cell Line, Mice, chemistry.chemical_compound, Biological property, Animals, Humans, Physical and Theoretical Chemistry, Aspergillus insulicola, Aspergillus, Dipeptide, Molecular Structure, biology, Chemistry, Organic Chemistry, Absolute configuration, Dipeptides, biology.organism_classification, Biogenesis
Abstract

Azonazine, a unique hexacyclic dipeptide, was isolated from a Hawaiian marine sediment-derived fungus eventually identified as Aspergillus insulicola. Its absolute configuration, 2R,10R,11S,19R, was established using NMR, HRESIMS, and CD data plus insights derived from molecular models. A possible route for its biogenesis is proposed, and biological properties were explored against cancer cell lines and in an NFκB inhibition assay.

Published
2010

2. The Aignopsanes, a New Class of Sesquiterpenes from Selected Chemotypes of the Sponge Cacospongia mycofijiensis

Author

James H. McKerrow, Phillip Crews, Allen G. Oliver, Karen Tenney, Taro Amagata, Teatulohi Matainaho, Tyler A. Johnson, Koneni V. Sashidhara, and Kenny K. H. Ang

Subjects
Stereochemistry, Trypanosoma brucei brucei, Cacospongia mycofijiensis, Trypanosoma brucei, Crystallography, X-Ray, Biochemistry, Article, Papua New Guinea, Parasitic Sensitivity Tests, parasitic diseases, Animals, Parasite hosting, Physical and Theoretical Chemistry, Nuclear Magnetic Resonance, Biomolecular, Molecular Structure, biology, Chemotype, Chemistry, Organic Chemistry, New guinea, biology.organism_classification, Nmr data, Porifera, Sponge, Trypanosomiasis, African, Sesquiterpenes
Abstract

A survey of individual specimens of northern Papua New Guinea derived Cacospongia mycofijiensis has yielded novel sesquiterpenes, aignopsanoic acid A (1), methyl aignopsanoate A (2), and isoaignopsanoic acid A (3). The structures and absolute configurations of 1-3 were established using NMR data, X-ray crystallography results, and an analysis of CD properties. Two of these metabolites, 1 and 2, were moderately active against Trypanosoma brucei, the parasite responsible for sleeping sickness.

Published
2009

3. The Aignopsanes, a New Class of Sesquiterpenes from Selected Chemotypes of the Sponge Cacospongia mycofijiensis.

Author

Tyler A. Johnson, Taro Amagata, Koneni V. Sashidhara, Allen G. Oliver, Karen Tenney, Teatulohi Matainaho, Kenny Kean-Hooi Ang, James H. McKerrow, and Phillip Crews

Subjects
*SESQUITERPENES, *SPONGES (Invertebrates), *NUCLEAR magnetic resonance spectroscopy, *CHEMICAL structure, *MARINE metabolites, *X-ray crystallography
Abstract

A survey of individual specimens of northern Papua New Guinea derived Cacospongia mycofijiensishas yielded novel sesquiterpenes, aignopsanoic acid A (1), methyl aignopsanoate A (2), and isoaignopsanoic acid A (3). The structures and absolute configurations of 1−3were established using NMR data, X-ray crystallography results, and an analysis of CD properties. Two of these metabolites, 1 and 2, were moderately active against Trypanosoma brucei, the parasite responsible for sleeping sickness. [ABSTRACT FROM AUTHOR]

Published
2009
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