1. Azonazine, a Novel Dipeptide from a Hawaiian Marine Sediment-Derived Fungus, Aspergillus insulicola
- Author
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Quan-Xiang Wu, Johann Sohn, Mitchell S. Crews, Phillip Crews, Tyler A. Johnson, Marija Draskovic, Leonard F. Bjeldanes, Frederick A. Valeriote, Karen Tenney, and Xiao-Jun Yao
- Subjects
Models, Molecular ,Molecular model ,Cell Survival ,Stereochemistry ,Fungus ,Biochemistry ,Article ,Cell Line ,Mice ,chemistry.chemical_compound ,Biological property ,Animals ,Humans ,Physical and Theoretical Chemistry ,Aspergillus insulicola ,Aspergillus ,Dipeptide ,Molecular Structure ,biology ,Chemistry ,Organic Chemistry ,Absolute configuration ,Dipeptides ,biology.organism_classification ,Biogenesis - Abstract
Azonazine, a unique hexacyclic dipeptide, was isolated from a Hawaiian marine sediment-derived fungus eventually identified as Aspergillus insulicola. Its absolute configuration, 2R,10R,11S,19R, was established using NMR, HRESIMS, and CD data plus insights derived from molecular models. A possible route for its biogenesis is proposed, and biological properties were explored against cancer cell lines and in an NFκB inhibition assay.
- Published
- 2010