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Your search keyword '"Trombini, C."' showing total 4 results
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4 results on '"Trombini, C."'

2. A New Protocol for the Acetoxyallylation of Aldehydes Mediated by Indium in THF

Author

Lombardo, M., Girotti, R., Morganti, S., and Trombini, C.

Abstract

A new precursor of a formal 1-hydroxy allyl anion is represented by 3-bromo-1-acetoxy-1-propene, which is synthesized by the ZnCl2-catalyzed addition of acetyl bromide to propenal. 3-Bromo-1-acetoxy-1-propene reacts with indium powder in THF to give the corresponding 3-acetoxylated ally indium complex, which regioselectively adds to aldehydes, affording monoprotected 1-en-3,4-diols. Diastereoselectivity mainly depends on the nature of the aldehyde; saturated aldehydes afford anti adducts, whereas the α,β-unsaturated aldehydes preferentially lead to the syn isomers.

Published
2001

3. <scp>d</scp>-Glucose-Derived 1,2,4-Trioxepanes: Synthesis, Conformational Study, and Antimalarial Activity

Author

Yolanda Corbett, Claudio Trombini, Arianna Quintavalla, Dilip D. Dhavale, Marco Lombardo, Donatella Taramelli, Dhiraj P. Sonawane, Sonawane, D P, Corbett, Y, Dhavale, D D, Taramelli, D, Trombini, C, Quintavalla, A, and Lombardo, M

Subjects
Stereochemistry, Plasmodium falciparum, Molecular Conformation, Adamantane, Biochemistry, Antimalarials, Structure-Activity Relationship, chemistry.chemical_compound, D-Glucose, Trioxepanes, Antimalarials, Glucose, Synthesis, Conformational study, Ic50 values, Physical and Theoretical Chemistry, IC50, Dose-Response Relationship, Drug, Molecular Structure, biology, Strain (chemistry), Chemistry, Organic Chemistry, Chloroquine, Stereoisomerism, biology.organism_classification, In vitro, Glucose, Oxepins, Derivative (chemistry)
Abstract

New enantiomerically pure 1,2,4-trioxepanes 10a,b/11a,b were synthesized from d-glucose. Their conformational behavior was studied by low-temperature NMR and substantiated by DFT calculations. On evaluation of in vitro antimalarial activity, the adamantyl derivative 11b showed IC50 values in the low micromolar range, particularly against the W2 chloroquine-resistant Plasmodium falciparum strain (IC50 = 0.15 ± 0.12 μM).

Published
2015

4. An efficient high-yield synthesis of D-ribo-phytosphingosine.

Author

Lombardo M, Capdevila MG, Pasi F, and Trombini C

Subjects
Catalysis, Molecular Structure, Sphingosine chemical synthesis, Sphingosine chemistry, Stereoisomerism, Aldehydes chemistry, Sphingosine analogs & derivatives
Abstract

[Structure: see text] [4R-[4alpha(S),5alpha]]-2,2-Dimethyl-4-(2-oxo-5-vinyl[1,3]dioxolan-4-yl)oxazolidine-3-carboxylic acid tert-butyl ester 5a, obtained in excellent yield and diastereoselectivity by the alpha-hydroxyallylation of the Garner aldehyde (4), is exploited in a novel high-yield synthesis of D-ribo-phytosphingosine (8), using microwave-enhanced cross metathesis as the key step in the chain elongation.

Published
2006
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