1. Chemical Synthesis of Biosurfactant Succinoyl Trehalose Lipids
- Author
-
Santanu Jana, Sumana Mondal, and Suvarn S. Kulkarni
- Subjects
010405 organic chemistry ,Chemistry ,Organic Chemistry ,Regioselectivity ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Trehalose ,Chemical synthesis ,0104 chemical sciences ,chemistry.chemical_compound ,Glycolipid ,Organic chemistry ,Surface modification ,Physical and Theoretical Chemistry - Abstract
Herein, we report, for the first time, a strategy to differentiate O4/O4′ positions of 1,1′-α,α-trehalose via regioselective protection or site-selective functionalization and its application in the first chemical synthesis of succinoyl trehalose lipids. The biosurfactant glycolipids were obtained in 11–12 steps starting from trehalose in time span of 8–10 days and 11–12% overall yields.
- Published
- 2017