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Your search keyword '"Shin, Young Sup"' showing total 3 results
Start Over Author "Shin, Young Sup" Journal organic letters
3 results on '"Shin, Young Sup"'

1. Asymmetric Synthesis of (−)-6′-β-Fluoro-aristeromycin via Stereoselective Electrophilic Fluorination

Author

Kim, Gyudong, Yoon, Ji-seong, Jarhad, Dnyandev B., Shin, Young Sup, Majik, Mahesh S., Mulamoottil, Varughese A., Hou, Xiyan, Qu, Shuhao, Park, Jiyong, Baik, Mu-Hyun, and Jeong, Lak Shin

Abstract

(−)-6′-β-Fluoro-aristeromycin (2), a potent inhibitor of S-adenosylhomocysteine (AdoHcy) hydrolase, has been synthesized via stereoselective electrophilic fluorination followed by a purine base build-up approach. Interestingly, purine base condensation using a cyclic sulfate resulted in a synthesis of (+)-5′-β-fluoro-isoaristeromycin (2a). Computational analysis indicates that the fluorine atom controlled the regioselectivity of the purine base substitution.

Published
2024
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3. Asymmetric Synthesis of (-)-6'-β-Fluoro-aristeromycin via Stereoselective Electrophilic Fluorination.

Author

Kim G, Yoon JS, Jarhad DB, Shin YS, Majik MS, Mulamoottil VA, Hou X, Qu S, Park J, Baik MH, and Jeong LS

Abstract

(-)-6'-β-Fluoro-aristeromycin (2), a potent inhibitor of S-adenosylhomocysteine (AdoHcy) hydrolase, has been synthesized via stereoselective electrophilic fluorination followed by a purine base build-up approach. Interestingly, purine base condensation using a cyclic sulfate resulted in a synthesis of (+)-5'-β-fluoro-isoaristeromycin (2a). Computational analysis indicates that the fluorine atom controlled the regioselectivity of the purine base substitution.

Published
2017
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