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Your search keyword '"Sayyadi, N"' showing total 2 results
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2 results on '"Sayyadi, N"'

1. N,O-Isopropylidenated Threonines as Tools for Peptide Cyclization:  Application to the Synthesis of Mahafacyclin B

Author

Sayyadi, N., Skropeta, D., and Jolliffe, K. A.

Abstract

The influence of a single N,O-isopropylidenated threonine turn-inducer on the cyclization of a linear heptapeptide precursor to mahafacyclin B has been investigated. Incorporation of an N,O-isopropylidenated threonine more than doubles the head-to-tail cyclization yield. The N,O-isopropylidene grouping is then readily disassembled to give the antimalarial cyclic peptide in high yield.

Published
2005

2. Synthesis of all-L cyclic tetrapeptides using pseudoprolines as removable turn inducers.

Author

Fairweather KA, Sayyadi N, Luck IJ, Clegg JK, and Jolliffe KA

Subjects
Models, Molecular, Molecular Conformation, Proline chemistry, Stereoisomerism, Oligopeptides chemical synthesis, Oligopeptides chemistry, Peptides, Cyclic chemical synthesis, Peptides, Cyclic chemistry, Proline analogs & derivatives, Thiazoles chemistry
Abstract

Cyclic tetrapeptides have generated great interest because of their broad-ranging biological properties. In order to synthesize these highly strained 12-membered cyclic compounds, a cyclization strategy using pseudoprolines as removable turn inducers has been developed. The pseudoproline derivatives induce a cisoid amide bond in the linear peptide backbone which facilitates cyclization. After cyclization, the turn inducers can be readily removed to afford cyclic tetrapeptides containing serine or threonine residues.

Published
2010
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