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Your search keyword '"Ohkubo, Takayuki"' showing total 4 results
Start Over Author "Ohkubo, Takayuki" Journal organic letters
4 results on '"Ohkubo, Takayuki"'

1. Scandium triflate-catalyzed N-[18F]Fluoroalkylation of aryl- or heteroaryl-amines with [18F]epifluorohydrin under mild condi-tions

Author

Masayuki, Fujinaga, Ohkubo, Takayuki, Tomoteru, Yamasaki, Katsushi, Kumata, Nobuki, Nengaki, and Zhang, Ming-Rong

Abstract

Scandium triflate-catalyzed N-[18F]fluoroalkylation of aryl- or heteroaryl-amines with [18F]epifluorohydrin ([18F]2) was investigated. This reaction is mild and provides one-step access to N-[18F]fluoroalkylated aryl- or heteroaryl-amines, which are used for positron emission tomography imaging. Use of 2,2,2-trifluoroethanol as a cosolvent improved the re-action efficiency. The use of (S)- or (R)-[18F]2 produced the corresponding enantiomeric N-[18F]fluoroalkylated anilines.

Published
2022

4. Scandium Triflate-Catalyzed N -[ 18 F]Fluoroalkylation of Aryl- Or Heteroaryl-Amines with [ 18 F]Epifluorohydrin under Mild Conditions.

Author

Fujinaga M, Ohkubo T, Yamasaki T, Kumata K, Nengaki N, and Zhang MR

Subjects
Catalysis, Mesylates, Molecular Structure, Amines, Scandium
Abstract

The scandium triflate-catalyzed N -[ 18 F]fluoroalkylation of aryl- or heteroaryl-amines with [ 18 F]epifluorohydrin ([ 18 F] 2 ) was investigated. This reaction is mild and provides one-step access to N -[ 18 F]fluoroalkylated aryl- or heteroaryl-amines, which are used for positron emission tomography imaging. The use of 2,2,2-trifluoroethanol as a cosolvent improved the reaction efficiency. The use of ( S )- and ( R )-[ 18 F] 2 produced the corresponding enantiomeric N -[ 18 F]fluoroalkylated anilines.

Published
2022
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