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2 results on '"Nick A. Paras"'

1. Water-Soluble Iridium Photoredox Catalyst for the Trifluoromethylation of Biomolecule Substrates in Phosphate Buffered Saline Solvent

Author

Jay Conrad, Nicholas S. Settineri, Connor J O'Brien, Nick A. Paras, Steven H. Olson, Terrence-Thang H Nguyen, Stanley B. Prusiner, and Minh L N Tran

Subjects
Hydrocarbons, Fluorinated, Light, chemistry.chemical_element, Peptide, 010402 general chemistry, Iridium, 01 natural sciences, Biochemistry, Catalysis, Phosphates, Microtiter plate, Physical and Theoretical Chemistry, chemistry.chemical_classification, Mesylates, Molecular Structure, 010405 organic chemistry, Trifluoromethylation, Biomolecule, Organic Chemistry, Water, 0104 chemical sciences, Solvent, chemistry, Reagent, Solvents, Nuclear chemistry
Abstract

The development of a water-soluble iridium catalyst enables the trifluoromethylation of polar small molecules and peptides in DMSO solution or aqueous media. The reaction was optimized in a microtiter plate format under ambient air, using commercial Langlois reagent as a CF3 radical source, blue LEDs for excitation, and using DPBS as solvent to provide up to 60% CF3- peptide.

Published
2021

2. Convenient route to secondary sulfinates: application to the stereospecific synthesis of α-C-chiral sulfonamides

Author

Michael W. Gribble, Jonathan B. Houze, Michael G. Johnson, and Nick A. Paras

Subjects
Sulfonamides, Aqueous solution, Primary (chemistry), Molecular Structure, Organic Chemistry, Stereoisomerism, Sulfinic Acids, Biochemistry, Catalysis, chemistry.chemical_compound, Hydroxylamine, Stereospecificity, Sulfonate, chemistry, Yield (chemistry), Organic chemistry, Physical and Theoretical Chemistry
Abstract

A convenient synthesis of α-chiral sulfinates from readily available precursors has been accomplished via the corresponding heterocyclic thioethers and sulfones. Treatment of the sulfinates with hydroxylamine sulfonate in aqueous solution provides α-C-chiral primary sulfonamides in good yield (14 examples) with retention of stereochemical purity.

Published
2014

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