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1. Stereostructure of a Novel Cytotoxic 18-Membered Macrolactone Antibiotic FD-891

Author

Eguchi, T., Kobayashi, K., Uekusa, H., Ohashi, Y., Mizoue, K., Matsushima, Y., and Kakinuma, K.

Abstract

The absolute stereochemistry of FD-891, a novel cytotoxic 18-membered macrolactone antibiotic, was determined by a synthetic approach as well as X-ray diffraction of degradative derivatives. The absolute configuration of FD-891 turned out to be as shown above. The stable conformer of FD-891 was also discussed with respect to biological activity by comparison with the structurally related concanamycin A on the bases of molecular mechanics calculations.

Published
2002
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