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7 results on '"Lin, Shuang"'

5. Probing Indole Diketopiperazine-Based Hybrids as Environmental-Induced Products from Aspergillussp. EGF 15-0-3

Author

Wei, Xia, Su, Jun-Cheng, Hu, Jin-Shan, He, Xi-Xin, Lin, Shuang-Jun, Zhang, Dong-Mei, Ye, Wen-Cai, Chen, Min-Feng, Lin, Hou-Wen, and Zhang, Cui-Xian

Abstract

Comprehensive analyses of the metabolite spectra of Aspergillussp. EGF 15-0-3 under different culture conditions revealed the presence of unique environmental-induced metabolites exclusively from the rice medium. Subsequent target isolation afforded four unprecedented indole diketopiperazine-based hybrids with a pyrano[3′,2′:7,8]isochromeno[4,3-b]pyrazino[2,1-i]indole core (1and 2) or a spiro[piperazine-2,2′-pyrano[3,4,5-de]chromene] scaffold (3and 4). Putative biosynthetic pathways for 1–4, with Diels–Alder cycloadditions as key steps, were proposed. 1–4exhibited selective cytotoxicities among several human cancer cells.

Published
2022
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7. Probing Indole Diketopiperazine-Based Hybrids as Environmental-Induced Products from Aspergillus sp. EGF 15-0-3.

Author

Wei X, Su JC, Hu JS, He XX, Lin SJ, Zhang DM, Ye WC, Chen MF, Lin HW, and Zhang CX

Abstract

Comprehensive analyses of the metabolite spectra of Aspergillus sp. EGF 15-0-3 under different culture conditions revealed the presence of unique environmental-induced metabolites exclusively from the rice medium. Subsequent target isolation afforded four unprecedented indole diketopiperazine-based hybrids with a pyrano[3',2':7,8]isochromeno[4,3- b ]pyrazino[2,1- i ]indole core ( 1 and 2 ) or a spiro[piperazine-2,2'-pyrano[3,4,5- de ]chromene] scaffold ( 3 and 4 ). Putative biosynthetic pathways for 1 - 4 , with Diels-Alder cycloadditions as key steps, were proposed. 1 - 4 exhibited selective cytotoxicities among several human cancer cells.

Published
2022
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