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Your search keyword '"Kennedy April L"' showing total 2 results
Start Over Author "Kennedy April L" Journal organic letters
2 results on '"Kennedy April L"'

1. A new resin-bound universal isonitrile for the Ugi 4CC reaction: preparation and applications to the synthesis of 2,5-diketopiperazines and 1,4-benzodiazepine-2,5-diones

Author

and Andrew M. Fryer, Kennedy April L, and John A. Josey

Subjects
chemistry.chemical_classification, Chemistry, Polymers, Carboxylic acid, Organic Chemistry, Biochemistry, Mass Spectrometry, Piperazines, Benzodiazepines, Nitriles, Organic chemistry, Indicators and Reagents, Spectrophotometry, Ultraviolet, Physical and Theoretical Chemistry, Diketopiperazines, Chromatography, High Pressure Liquid
Abstract

[reaction: see text] The preparation and synthetic applications of a novel resin-bound isonitrile are described. The resin is an example of a novel convertible isonitrile that can be utilized in the Ugi multicomponent reaction. Base-activation of the resin-bound Ugi product results in cleavage via formation of a N-acyloxazolidone that is then trapped as a carboxylic acid ester. This resin and the methodology described are suitable for synthesizing diversity libraries of 2,5-diketopiperazines and 1,4-benzodiazepine-2,5-diones.

Published
2002

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