1. Macrocyclic scaffold for the collagen triple helix.
- Author
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Horng JC, Hawk AJ, Zhao Q, Benedict ES, Burke SD, and Raines RT
- Subjects
- Amino Acid Sequence, Collagen chemical synthesis, Models, Molecular, Molecular Structure, Protein Conformation, Thermodynamics, Collagen chemistry
- Abstract
[structure: see text] Three strands of natural collagen are linked by covalent bonds prior to their folding into a triple helix. We report on a synthetic collagen in which the strands are pendent on a rigid macrocyclic scaffold of C(3) symmetry. The scaffold confers substantial conformational stability upon the collagen triple helix and makes its folding independent of concentration, both desirable attributes for exploring and exploiting synthetic collagens.
- Published
- 2006
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