1. Carbene-Catalyzed α-Carbon Amination of Chloroaldehydes for Enantioselective Access to Dihydroquinoxaline Derivatives
- Author
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Xiangyang Li, Xingkuan Chen, Yonggui Robin Chi, Zhichao Jin, Chengli Mou, Guoyong Luo, Ruoyan Huang, Yongjia Li, Wei Xue, and School of Physical and Mathematical Sciences
- Subjects
Chemistry::Organic chemistry [Science] ,010405 organic chemistry ,Bioactive molecules ,Organic Chemistry ,Synthon ,Enantioselective synthesis ,chemistry.chemical_element ,Enantioselectivity ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Combinatorial chemistry ,0104 chemical sciences ,Catalysis ,chemistry.chemical_compound ,chemistry ,N-Heterocyclic Carbene Catalysis ,Reagent ,Physical and Theoretical Chemistry ,Carbene ,Carbon ,Amination - Abstract
An NHC-catalyzed α-carbon amination of chloroaldehydes was developed. Cyclohexadiene-1,2-diimines are used as amination reagents and four-atom synthons. Our reaction affords optically enriched dihydroquinoxalines that are core structures in natural products and synthetic bioactive molecules. NRF (Natl Research Foundation, S’pore) ASTAR (Agency for Sci., Tech. and Research, S’pore) MOE (Min. of Education, S’pore) Accepted version
- Published
- 2019