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Your search keyword '"Fei-Xian, Luo"' showing total 5 results
Start Over Author "Fei-Xian, Luo" Journal organic letters
5 results on '"Fei-Xian, Luo"'

2. Pd/Cu-Catalyzed Cascade C(sp3)–H Arylation and Intramolecular C–N Coupling: A One-Pot Synthesis of 3,4-2H-Quinolinone Skeletons

Author

Fei-Xian Luo, Bo-Wen Li, Xiao-Dong Wang, Wen-Shu Wang, Wei-Li Lin, Hao Luo, Han-Zhi Xiao, and Yu-Song Sun

Subjects
010405 organic chemistry, Chemistry, Organic Chemistry, One-pot synthesis, Intermolecular force, Regioselectivity, 010402 general chemistry, 01 natural sciences, Biochemistry, Coupling reaction, 0104 chemical sciences, Catalysis, Coupling (electronics), Cascade, Intramolecular force, Polymer chemistry, Physical and Theoretical Chemistry
Abstract

In this letter, we successfully explored a cascade Pd/Cu-catalyzed intermolecular C(sp3)–H arylation of amides and intramolecular C–N coupling reaction. This method provides a one-pot strategy to synthesize 3,4-2H-quinolinone with good regioselectivity of C–H arylation and C–N coupling from C–I and C–X bonds from readily available starting materials.

Published
2019
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3. Cu-Catalyzed Alkynylation of Unactivated C(sp(3))-X Bonds with Terminal Alkynes through Directing Strategy

Author

Xing Xu, Ding Wang, Zhang-Jie Shi, Zhi-Chao Cao, Yun-Fei Zhang, and Fei-Xian Luo

Subjects
chemistry.chemical_classification, 010405 organic chemistry, Organic Chemistry, Halide, Substrate (chemistry), 010402 general chemistry, 01 natural sciences, Biochemistry, Medicinal chemistry, Combinatorial chemistry, 0104 chemical sciences, Catalysis, Alkynylation, chemistry, Transition metal, Terminal (electronics), Reactivity (chemistry), Physical and Theoretical Chemistry, Alkyl
Abstract

In this letter, we report an efficient and concise protocol for Cu-catalyzed cross-coupling of unactivated alkyl halides/peusudohalides with terminal alkynes to afford internal alkynes with the assistance of various amides as directing groups. Different alkyl halides/pseudohalides exhibited excellent reactivities, and the inactivated alkyl chlorides and sulfonates showed better reactivity than bromides/iodides. This is the first successful example to apply alkyl chlorides and sulfonates directly in cross-coupling with terminal alkynes in the absence of any additives. A Cu catalyst was found to be more effective than other transition metal catalysts. This reaction also exhibited a broad substrate scope with respect to terminal alkynes.

Published
2016

5. Cu-Catalyzed Alkynylation of Unactivated C(sp3)-X Bonds with Terminal Alkynes through Directing Strategy.

Author

Fei-Xian Luo, Xing Xu, Ding Wang, Zhi-Chao Cao, Yun-Fei Zhang, and Zhang-Jie Shi

Subjects
*COPPER catalysts, *CATALYSIS, *ALKYNES, *CARBON compounds, *CHEMICAL bonds, *COUPLING reactions (Chemistry), *SULFONATES
Abstract

In this letter, we report an efficient and concise protocol for Cu-catalyzed cross-coupling of unactivated alkyl halides/peusudohalides with terminal alkynes to afford internal alkynes with the assistance of various amides as directing groups. Different alkyl halides/pseudohalides exhibited excellent reactivities, and the inactivated alkyl chlorides and sulfonates showed better reactivity than bromides/iodides. This is the first successful example to apply alkyl chlorides and sulfonates directly in cross-coupling with terminal alkynes in the absence of any additives. A Cu catalyst was found to be more effective than other transition metal catalysts. This reaction also exhibited a broad substrate scope with respect to terminal alkynes. [ABSTRACT FROM AUTHOR]

Published
2016
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