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Your search keyword '"Dong-Hui Wang"' showing total 9 results
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9 results on '"Dong-Hui Wang"'

1. Cu-Catalyzed Synthesis of Benzoxazole with Phenol and Cyclic Oxime

Author

Zheng-Hai Wang and Dong-Hui Wang

Subjects
Organic Chemistry, Physical and Theoretical Chemistry, Biochemistry
Abstract

A Cu-catalyzed straightforward synthesis of benzoxazoles from free phenols and cyclic oxime esters is reported. The mild reaction conditions tolerate various electron-withdrawing and electron-donating functional groups on both substrates, affording benzoxazoles in moderate to good yields. With this protocol, large-scale syntheses of

Published
2021

2. Copper-Catalyzed Methoxylation of Aryl Bromides with 9-BBN−OMe

Author

Zhi-Qiang Song, Dong-Hui Wang, Jing-Ru Wang, and Chen Li

Subjects
chemistry.chemical_compound, chemistry, Ligand, Aryl, Organic Chemistry, Copper catalyzed, Physical and Theoretical Chemistry, Anisole, Biochemistry, Medicinal chemistry, Bromobenzenes
Abstract

A Cu-catalyzed cross-coupling reaction between aryl bromides and 9-BBN-OMe to provide aryl methyl ethers under mild conditions is reported. The oxalamide ligand BHMPO plays a key role in the transformation. Various functional groups on bromobenzenes are well tolerated, providing the desired anisole products in moderate to high yields.

Published
2021

3. Copper-Catalyzed 3-Positional Amination of 2-Azulenols with O-Benzoylhydroxylamines

Author

Meng Li and Dong-Hui Wang

Subjects
Chemistry, Organic Chemistry, Copper catalyzed, Physical and Theoretical Chemistry, Biochemistry, Combinatorial chemistry, Amination
Abstract

A copper-catalyzed ortho-selective amination of 2-azulenols with O-benzoylhydroxylamines (RR'N-OBz) to synthesize ortho-aminoazulenols is reported. A wide range of functional groups on amines are compatible, furnishing the corresponding amino-azulene derivatives in moderate to good yields. The further synthetic elaboration using 3-amino-2-azulenols as starting materials is demonstrated.

Published
2021

9. Expedient Drug Synthesis and Diversification via ortho-C−H Iodination using Recyclable PdI2as the Precatalyst.

Author

Tian-Sheng Mei, Dong-Hui Wang, and Jin-Quan Yu

Subjects
*DRUG development, *PALLADIUM catalysts, *CHEMICAL reactions, *PHENYLACETIC acid, *AMIDES, *DICLOFENAC, *IODINE
Abstract

Pd(II)-catalyzed ortho-C−H iodination reactions of phenylacetic acid substrates have been achieved using recyclable PdI2as the precatalyst. This class of substrates is incompatible with the classic amide formation/ortho-lithiation/iodination sequence. The power of this new technology is demonstrated by facile drug functionalization and drastically shortened syntheses of the drugs diclofenac and lumiracoxib. [ABSTRACT FROM AUTHOR]

Published
2010
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