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Your search keyword '"Dong Jae Baek"' showing total 4 results
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4 results on '"Dong Jae Baek"'

1. IgG Antibody Response Elicited by a Fully Synthetic Two-Component Carbohydrate-Based Cancer Vaccine Candidate with α-Galactosylceramide as Built-in Adjuvant

Author

Zhong-Yin Zhou, Dong Jae Baek, Zheng Liu, Wen-Mei Sun, Pan-Pan Ji, Jun Guo, Guang-Fu Yang, Xiao-Shan Geng, Xiang-Zhao Chen, Jian Wang, Xu-Guang Yin, and Xiao-Kang Zhang

Subjects
medicine.medical_treatment, Cell, 010402 general chemistry, 01 natural sciences, Biochemistry, medicine, Physical and Theoretical Chemistry, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Carbohydrate, Ligand (biochemistry), Molecular biology, Combinatorial chemistry, nervous system diseases, 0104 chemical sciences, surgical procedures, operative, Antibody response, medicine.anatomical_structure, nervous system, Immunoglobulin class switching, biology.protein, Cancer vaccine, Antibody, therapeutics, Adjuvant
Abstract

A fully synthetic self-adjuvanting cancer vaccine candidate was constructed through covalent conjugation of invariant natural killer T (iNKT) cell ligand α-galactosylceramide (αGalCer) with sialyl Tn (STn), a representative tumor-associated carbohydrate antigen (TACA). This two-component vaccine STn-αGalCer is devoid of antigenic peptide, featuring the well-defined structure with high simplicity. STn-αGalCer showed remarkable efficacy in inducing antibody class switching from IgM to STn-specific IgG. Subtypes of IgG antibody were primarily IgG1 and IgG3.

Published
2017

2. Efficient synthesis of (+)-MK7607 and its C-1 epimer via the stereoselective transposition of a tertiary allylic alcohol

Author

Sanghee Kim, Deukjoon Kim, Chaemin Lim, Dong Jae Baek, and So Won Youn

Subjects
Allylic rearrangement, Molecular Structure, Stereochemistry, Propanols, organic chemicals, Organic Chemistry, Transposition (telecommunications), food and beverages, Halogenation, Galactose, Alcohol, Stereoisomerism, Allylic alcohol, Biochemistry, Catalysis, chemistry.chemical_compound, Stereospecificity, chemistry, Phenols, Stereoselectivity, Epimer, Physical and Theoretical Chemistry, Palladium
Abstract

These studies provide an efficient and stereoselective synthetic route to (+)-MK7607 and its C-1 epimer from a common intermediate in high overall yields. The synthetic methodologies mainly rely on the stereospecific 1,3-allylic transposition of the hindered tertiary alcohol group through a palladium-catalyzed allylic rearrangement as well as a PBr(3)-mediated allylic-transposed bromination.

Published
2009

4. Efficient Synthesis of (+)-MK7607 and its C-1 Epimer via the Stereoselective Transposition of a Tertiary Allylic Alcohol.

Author

Chaemin Lim, Dong Jae Baek, Deukjoon Kim, So Won Youn, and Sanghee Kim

Subjects
*ORGANIC synthesis, *UNSATURATED compounds, *INTERMEDIATES (Chemistry), *REARRANGEMENTS (Chemistry), *ALCOHOL, *STEREOCHEMISTRY, *ORGANIC chemistry
Abstract

These studies provide an efficient and stereoselective synthetic route to (+)-MK7607 and its C-1 epimer from a common intermediate in high overall yields. The synthetic methodologies mainly rely on the stereospecific 1,3-allylic transposition of the hindered tertiary alcohol group through a palladium-catalyzed allylic rearrangement as well as a PBr3-mediated allylic-transposed bromination. [ABSTRACT FROM AUTHOR]

Published
2009
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