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1. Combining Fluoroalkylation and Defluorination to Enable Formal [3 + 2 + 1] Heteroannulation by Using Visible-Light Photoredox Organocatalysis

Author

Teck-Peng Loh, Zhi-Liang Shen, Ting Xie, Xue-Qiang Chu, Lin Li, and Danhua Ge

Subjects
010405 organic chemistry, Chemistry, Organic Chemistry, Regioselectivity, Silyl enol ether, 010402 general chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, 0104 chemical sciences, Amidine, chemistry.chemical_compound, Organocatalysis, Functional group, Organofluorine compounds, Physical and Theoretical Chemistry, Visible spectrum
Abstract

A metal-free, visible-light photoredox-catalyzed three-component [3 + 2 + 1] heteroannulation for accessing modular fluoroalkylated pyrimidines from readily available silyl enol ether, amidine, and fluoroalkyl halide is developed. This protocol distinguishes itself by broad functional group tolerance in a regioselective manner, which provides a complement to the existing methods for the construction of pharmaceutically and biologically active organofluorine compounds.

Published
2018

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