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2 results on '"Chengxiang Zhou"'

1. Synthesis of tetrasubstituted olefins by Pd-catalyzed addition of arylboronic acids to internal alkynes

Author

Chengxiang Zhou and Richard C. Larock

Subjects
chemistry.chemical_classification, Reaction conditions, Aryl, Organic Chemistry, Acetal, Alcohol, General Medicine, Triple bond, Biochemistry, Aldehyde, Catalysis, chemistry.chemical_compound, chemistry, Organic chemistry, Physical and Theoretical Chemistry
Abstract

[Reaction: see text] Tetrasubstituted olefins are readily prepared by the Pd-catalyzed cis addition of two aryl groups from an arylboronic acid to opposite ends of the triple bond of internal alkynes. The synthesis proceeds under very mild reaction conditions and tolerates a wide variety of functional groups, including alcohol, aldehyde, ester, TMS, and acetal groups.

Published
2005

2. An Efficient, Regio- and Stereoselective Palladium-Catalyzed Route to Tetrasubstituted Olefins

Author

Daniel E. Emrich, Chengxiang Zhou, and Richard C. Larock

Subjects
chemistry.chemical_classification, Aryl, Aryl halide, Iodide, Organic Chemistry, chemistry.chemical_element, Alkyne, General Medicine, Combinatorial chemistry, Biochemistry, Catalysis, chemistry.chemical_compound, chemistry, Organic chemistry, Stereoselectivity, Physical and Theoretical Chemistry, Palladium
Abstract

An efficient, regio- and stereoselective palladium-catalyzed route to tetrasubstituted olefins has been developed, which involves the intermolecular coupling of an aryl iodide, an internal alkyne, and an arylboronic acid. The reaction involves cis-addition of the aryl group from the aryl halide to the less hindered or less electron-poor end of the alkyne, while the aryl group from the arylboronic acid adds to the other end. [reaction: see text]

Published
2003
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