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6 results on '"Chen, Hongfeng"'

5. The first total synthesis of 15-deoxy-Delta12,14-prostaglandin J2 and the unambiguous assignment of the C14 stereochemistry.

Author

Brummond KM, Sill PC, and Chen H

Subjects
Carbon chemistry, Cyclization, Molecular Structure, Silicon chemistry, Stereoisomerism, Prostaglandin D2 analogs & derivatives, Prostaglandin D2 chemical synthesis
Abstract

[reaction: see text] The first total synthesis of 15-deoxy-Delta12,14-prostaglandin J2 is reported. The highly unsaturated cyclopentenone prostaglandin was obtained via a silicon-tethered allenic [2 + 2 + 1] cycloaddition reaction developed in our group. In addition, the stereochemistry at C14 has been assigned unambiguously.

Published
2004
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6. An allenic Pauson-Khand-type reaction: a reversal in pi-bond selectivity and the formation of seven-membered rings.

Author

Brummond KM, Chen H, Fisher KD, Kerekes AD, Rickards B, Sill PC, and Geib SJ

Subjects
Crystallography, X-Ray, Cyclization, Indicators and Reagents, Models, Molecular, Molecular Conformation, Silicones chemistry, Alkadienes chemistry
Abstract

[reaction: see text] Treatment of alkynyl allenes with [Rh(CO)(2)Cl](2) results in a formal [2 + 2 + 1] cycloaddition reaction. This reaction occurs with complete regioselectivity for a variety of substrates affording only 4-alkylidene cyclopentenones in good yields. Moreover, seven-membered rings have been prepared in high yields.

Published
2002
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